schliessen

Filtern

 

Bibliotheken

Apo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbalip.2011.09.002 Byline: E. Gouranton, G. Aydemir, E. Reynaud, J. Marcotorchino, C. Malezet, C. Caris-Veyrat, R. Blomhoff, J.F. Landrier, R. Ruhl Keywords: Lycopene; apo-10'-lycopenoic acid; Adipocytes; Adip... Full description

Journal Title: BBA - Molecular and Cell Biology of Lipids Dec, 2011, Vol.1811(12), p.1105(10)
Main Author: Gouranton, E.
Other Authors: Aydemir, G. , Reynaud, E. , Marcotorchino, J. , Malezet, C. , Caris - Veyrat, C. , Blomhoff, R. , Landrier, J. F. , Ruhl, R.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 1388-1981
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: gale_ofa272908759
title: Apo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors
format: Article
creator:
  • Gouranton, E.
  • Aydemir, G.
  • Reynaud, E.
  • Marcotorchino, J.
  • Malezet, C.
  • Caris - Veyrat, C.
  • Blomhoff, R.
  • Landrier, J. F.
  • Ruhl, R.
subjects:
  • Lycopene -- Analysis
  • Lycopene -- Physiological Aspects
  • Metabolites -- Analysis
  • Metabolites -- Physiological Aspects
  • Gene Expression -- Analysis
  • Gene Expression -- Physiological Aspects
  • Genes -- Analysis
  • Genes -- Physiological Aspects
  • Adipose Tissue -- Analysis
  • Adipose Tissue -- Physiological Aspects
ispartof: BBA - Molecular and Cell Biology of Lipids, Dec, 2011, Vol.1811(12), p.1105(10)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbalip.2011.09.002 Byline: E. Gouranton, G. Aydemir, E. Reynaud, J. Marcotorchino, C. Malezet, C. Caris-Veyrat, R. Blomhoff, J.F. Landrier, R. Ruhl Keywords: Lycopene; apo-10'-lycopenoic acid; Adipocytes; Adipose tissue; Inflammation; RAR Abstract: Apo-10'-lycopenoic acid (apo-10-lycac), a metabolite of lycopene, has been shown to possess potent biological activities, notably via the retinoic acid receptors (RAR). In the current study, its impact on adipose tissue and adipocytes was studied. In microarray experiments, the set of genes regulated by apo-10-lycac treatments was compared to the set of genes regulated by all-trans retinoic acid (ATRA), the natural ligand of RAR, in adipocytes. Approximately 27.5% of the genes regulated by apo-10-lycac treatments were also regulated by ATRA, suggesting a common ability in terms of gene expression modulation, possibly via RAR transactivation. The physiological impact of apo-10-lycac on adipose tissue biology was evaluated. If it had no effect on adipogenesis in the 3T3-L1 cell model, this metabolite may have a preventative effect against inflammation, by preventing the increase in the inflammatory markers, interleukin 6 and interleukin 1[beta] in various dedicated models. The ability of apo-10-lycac to transactivate the RAR and to modulate the transcription of RAR target gene was brought in vivo in adipose tissue. While apo-10-lycac was not detected in adipose tissue, a metabolite with a molecular weight with 2Da larger mass was detected, suggesting that a dihydro-apo-10'-lycopenoic acid, may be present in adipose tissue and that this compound could active or may lead to further active RAR-activating apo-10-lycac metabolites. Since apo-10-lycac treatments induce anti-inflammatory effects in adipose tissue but do not inhibit adipogenesis, we propose that apo-10-lycac treatments and its potential active metabolites in WAT may be considered for prevention strategies relevant for obesity-associated pathologies. Article History: Received 28 April 2011; Revised 23 August 2011; Accepted 9 September 2011
language: English
source: Cengage Learning, Inc.
identifier: ISSN: 1388-1981
fulltext: fulltext
issn:
  • 1388-1981
  • 13881981
url: Link


@attributes
ID687940058
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid272908759
sourceidgale_ofa
recordidTN_gale_ofa272908759
sourceformatXML
sourcesystemPC
galeid272908759
display
typearticle
titleApo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors
creatorGouranton, E. ; Aydemir, G. ; Reynaud, E. ; Marcotorchino, J. ; Malezet, C. ; Caris - Veyrat, C. ; Blomhoff, R. ; Landrier, J. F. ; Ruhl, R.
ispartofBBA - Molecular and Cell Biology of Lipids, Dec, 2011, Vol.1811(12), p.1105(10)
identifierISSN: 1388-1981
subjectLycopene -- Analysis ; Lycopene -- Physiological Aspects ; Metabolites -- Analysis ; Metabolites -- Physiological Aspects ; Gene Expression -- Analysis ; Gene Expression -- Physiological Aspects ; Genes -- Analysis ; Genes -- Physiological Aspects ; Adipose Tissue -- Analysis ; Adipose Tissue -- Physiological Aspects
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbalip.2011.09.002 Byline: E. Gouranton, G. Aydemir, E. Reynaud, J. Marcotorchino, C. Malezet, C. Caris-Veyrat, R. Blomhoff, J.F. Landrier, R. Ruhl Keywords: Lycopene; apo-10'-lycopenoic acid; Adipocytes; Adipose tissue; Inflammation; RAR Abstract: Apo-10'-lycopenoic acid (apo-10-lycac), a metabolite of lycopene, has been shown to possess potent biological activities, notably via the retinoic acid receptors (RAR). In the current study, its impact on adipose tissue and adipocytes was studied. In microarray experiments, the set of genes regulated by apo-10-lycac treatments was compared to the set of genes regulated by all-trans retinoic acid (ATRA), the natural ligand of RAR, in adipocytes. Approximately 27.5% of the genes regulated by apo-10-lycac treatments were also regulated by ATRA, suggesting a common ability in terms of gene expression modulation, possibly via RAR transactivation. The physiological impact of apo-10-lycac on adipose tissue biology was evaluated. If it had no effect on adipogenesis in the 3T3-L1 cell model, this metabolite may have a preventative effect against inflammation, by preventing the increase in the inflammatory markers, interleukin 6 and interleukin 1[beta] in various dedicated models. The ability of apo-10-lycac to transactivate the RAR and to modulate the transcription of RAR target gene was brought in vivo in adipose tissue. While apo-10-lycac was not detected in adipose tissue, a metabolite with a molecular weight with 2Da larger mass was detected, suggesting that a dihydro-apo-10'-lycopenoic acid, may be present in adipose tissue and that this compound could active or may lead to further active RAR-activating apo-10-lycac metabolites. Since apo-10-lycac treatments induce anti-inflammatory effects in adipose tissue but do not inhibit adipogenesis, we propose that apo-10-lycac treatments and its potential active metabolites in WAT may be considered for prevention strategies relevant for obesity-associated pathologies. Article History: Received 28 April 2011; Revised 23 August 2011; Accepted 9 September 2011
languageEnglish
sourceCengage Learning, Inc.
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
scope
0gale_onefilea
1gale_onefileg
2OneFile
creatorcontrib
0Gouranton, E
1E. Gouranton
2Aydemir, G
3Reynaud, E
4Marcotorchino, J
5Malezet, C
6Caris-Veyrat, C
7Blomhoff, R
8Landrier, J.F
9Ruhl, R
titleApo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors.
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbalip.2011.09.002 Byline: E. Gouranton, G. Aydemir, E. Reynaud, J. Marcotorchino, C. Malezet, C. Caris-Veyrat, R. Blomhoff, J.F. Landrier, R. Ruhl Keywords: Lycopene; apo-10'-lycopenoic acid; Adipocytes; Adipose tissue; Inflammation; RAR Abstract: Apo-10'-lycopenoic acid (apo-10-lycac), a metabolite of lycopene, has been shown to possess potent biological activities, notably via the retinoic acid receptors (RAR). In the current study, its impact on adipose tissue and adipocytes was studied. In microarray experiments, the set of genes regulated by apo-10-lycac treatments was compared to the set of genes regulated by all-trans retinoic acid (ATRA), the natural ligand of RAR, in adipocytes. Approximately 27.5% of the genes regulated by apo-10-lycac treatments were also regulated by ATRA, suggesting a common ability in terms of gene expression modulation, possibly via RAR transactivation. The physiological impact of apo-10-lycac on adipose tissue biology was evaluated. If it had no effect on adipogenesis in the 3T3-L1 cell model, this metabolite may have a preventative effect against inflammation, by preventing the increase in the inflammatory markers, interleukin 6 and interleukin 1[beta] in various dedicated models. The ability of apo-10-lycac to transactivate the RAR and to modulate the transcription of RAR target gene was brought in vivo in adipose tissue. While apo-10-lycac was not detected in adipose tissue, a metabolite with a molecular weight with 2Da larger mass was detected, suggesting that a dihydro-apo-10'-lycopenoic acid, may be present in adipose tissue and that this compound could active or may lead to further active RAR-activating apo-10-lycac metabolites. Since apo-10-lycac treatments induce anti-inflammatory effects in adipose tissue but do not inhibit adipogenesis, we propose that apo-10-lycac treatments and its potential active metabolites in WAT may be considered for prevention strategies relevant for obesity-associated pathologies. Article History: Received 28 April 2011; Revised 23 August 2011; Accepted 9 September 2011
subject
0Lycopene--Analysis
1Lycopene--Physiological aspects
2Metabolites--Analysis
3Metabolites--Physiological aspects
4Gene expression--Analysis
5Gene expression--Physiological aspects
6Genes--Analysis
7Genes--Physiological aspects
8Adipose tissue--Analysis
9Adipose tissue--Physiological aspects
general
0English
1Elsevier B.V.
2Cengage Learning, Inc.
sourceidgale_ofa
recordidgale_ofa272908759
issn
01388-1981
113881981
rsrctypearticle
creationdate2011
recordtypearticle
addtitleBBA - Molecular and Cell Biology of Lipids
searchscopeOneFile
sort
titleApo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors.
authorGouranton, E. ; Aydemir, G. ; Reynaud, E. ; Marcotorchino, J. ; Malezet, C. ; Caris - Veyrat, C. ; Blomhoff, R. ; Landrier, J. F. ; Ruhl, R.
creationdate20111201
facets
frbrgroupid-1621994547470624123
frbrtype6
languageeng
creationdate2011
topic
0Lycopene–Analysis
1Lycopene–Physiological Aspects
2Metabolites–Analysis
3Metabolites–Physiological Aspects
4Gene Expression–Analysis
5Gene Expression–Physiological Aspects
6Genes–Analysis
7Genes–Physiological Aspects
8Adipose Tissue–Analysis
9Adipose Tissue–Physiological Aspects
collectionOneFile (GALE)
prefilterarticles
rsrctypearticles
creatorcontrib
0Gouranton, E.
1Aydemir, G.
2Reynaud, E.
3Marcotorchino, J.
4Malezet, C.
5Caris - Veyrat, C.
6Blomhoff, R.
7Landrier, J. F.
8Ruhl, R.
jtitleBBA - Molecular and Cell Biology of Lipids
toplevelpeer_reviewed
frbr
t2
k12011
k213881981
k41811
k512
k61105
k7bba molecular cell biology of lipids
k8apo 10 apos lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors
k9apo10aposlycopenoicaptors
k12apo10aposlycopenoicacidim
k15egouranton
k16gourantone
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typeaggregator
addata
au
0Gouranton, E.
1Aydemir, G.
2Reynaud, E.
3Marcotorchino, J.
4Malezet, C.
5Caris-Veyrat, C.
6Blomhoff, R.
7Landrier, J.F.
8Ruhl, R.
atitleApo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors.
jtitleBBA - Molecular and Cell Biology of Lipids
risdate20111201
volume1811
issue12
spage1105
issn1388-1981
genrearticle
ristypeJOUR
abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbalip.2011.09.002 Byline: E. Gouranton, G. Aydemir, E. Reynaud, J. Marcotorchino, C. Malezet, C. Caris-Veyrat, R. Blomhoff, J.F. Landrier, R. Ruhl Keywords: Lycopene; apo-10'-lycopenoic acid; Adipocytes; Adipose tissue; Inflammation; RAR Abstract: Apo-10'-lycopenoic acid (apo-10-lycac), a metabolite of lycopene, has been shown to possess potent biological activities, notably via the retinoic acid receptors (RAR). In the current study, its impact on adipose tissue and adipocytes was studied. In microarray experiments, the set of genes regulated by apo-10-lycac treatments was compared to the set of genes regulated by all-trans retinoic acid (ATRA), the natural ligand of RAR, in adipocytes. Approximately 27.5% of the genes regulated by apo-10-lycac treatments were also regulated by ATRA, suggesting a common ability in terms of gene expression modulation, possibly via RAR transactivation. The physiological impact of apo-10-lycac on adipose tissue biology was evaluated. If it had no effect on adipogenesis in the 3T3-L1 cell model, this metabolite may have a preventative effect against inflammation, by preventing the increase in the inflammatory markers, interleukin 6 and interleukin 1[beta] in various dedicated models. The ability of apo-10-lycac to transactivate the RAR and to modulate the transcription of RAR target gene was brought in vivo in adipose tissue. While apo-10-lycac was not detected in adipose tissue, a metabolite with a molecular weight with 2Da larger mass was detected, suggesting that a dihydro-apo-10'-lycopenoic acid, may be present in adipose tissue and that this compound could active or may lead to further active RAR-activating apo-10-lycac metabolites. Since apo-10-lycac treatments induce anti-inflammatory effects in adipose tissue but do not inhibit adipogenesis, we propose that apo-10-lycac treatments and its potential active metabolites in WAT may be considered for prevention strategies relevant for obesity-associated pathologies. Article History: Received 28 April 2011; Revised 23 August 2011; Accepted 9 September 2011
pubElsevier B.V.
lad01gale_ofa
date2011-12-01