schliessen

Filtern

 

Bibliotheken

Very-low-calorie diet: a quick therapeutic tool to improve [beta] cell function in morbidly obese patients with type 2 diabetes.(Original Research Communications)(Author abstract)(Report)

Background: Caloric restriction in obese diabetic patients quickly improves glucose control, independently from weight loss. However, the early effects of a very-low-calorie diet (VLCD) on insulin sensitivity and insulin secretion in morbidly obese patients with type 2 diabetes are still unclear. Ob... Full description

Journal Title: American Journal of Clinical Nutrition March, 2012, Vol.95(3), p.609(5)
Main Author: Malandrucco, Ilaria
Other Authors: Pasqualetti, Patrizio , Giordani, Ilaria , Manfellotto, Dario , De Marco, Federica , Alegiani, Filippo , Sidoti, Anna Maria , Picconi, Fabiana , Flaviani, Alessandra Di , Frajese, Gaetano , Bonadonna, Riccardo C. , Frontoni, Simona
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-9165
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: gale_ofa282326039
title: Very-low-calorie diet: a quick therapeutic tool to improve [beta] cell function in morbidly obese patients with type 2 diabetes.(Original Research Communications)(Author abstract)(Report)
format: Article
creator:
  • Malandrucco, Ilaria
  • Pasqualetti, Patrizio
  • Giordani, Ilaria
  • Manfellotto, Dario
  • De Marco, Federica
  • Alegiani, Filippo
  • Sidoti, Anna Maria
  • Picconi, Fabiana
  • Flaviani, Alessandra Di
  • Frajese, Gaetano
  • Bonadonna, Riccardo C.
  • Frontoni, Simona
subjects:
  • Low Calorie Diet -- Health Aspects
  • Low Calorie Diet -- Research
  • Obesity -- Risk Factors
  • Obesity -- Care And Treatment
  • Obesity -- Research
  • Type 2 Diabetes -- Complications And Side Effects
  • Type 2 Diabetes -- Research
ispartof: American Journal of Clinical Nutrition, March, 2012, Vol.95(3), p.609(5)
description: Background: Caloric restriction in obese diabetic patients quickly improves glucose control, independently from weight loss. However, the early effects of a very-low-calorie diet (VLCD) on insulin sensitivity and insulin secretion in morbidly obese patients with type 2 diabetes are still unclear. Objective: The objective was to study the relative contributions of insufin sensitivity, insulin secretion, or both to improvement in glucose metabolism, after 1 wk of caloric restriction, in severely obese diabetic patients. Design: Hyperglycemic clamps were performed in 14 severely obese (BMI, in kg/[m.sup.2]: >40) patients with type 2 diabetes in good glucose control (glycated hemoglobin < 7.5%) before and after 7 d of a VLCD (400 kcal/d). Results: The VLCD caused a 3.22 [+ or -] 0.56% weight loss (P < 0.001), 42.0% of which was fat loss, accompanied by decreases in fasting plasma glucose (P < 0.05) and triglycerides (P < 0.01). In parallel, the Disposition Index, which measures the body's capability to dispose of a glucose load, increased from 59.0 [+ or -] 6.3 to 75.5 [+ or -] 6.3 mL. [min.sup.-1] * [m.sup.-2] body surface area (P < 0.01), because of improvements in indexes of both first- and second-phase insulin secretion (P < 0.02), but with no changes in insulin sensitivity (P = 0.33). Conclusion: The marked improvement in metabolic profile, observed in severely obese patients with type 2 diabetes after a 7-d VLCD, was primarily due to the amelioration of [beta] cell function, whereas no contribution of insulin sensitivity was shown. This trial was registered at www.clinicaltrials.gov as NCT01447524. Doi: 10.3945/ajcn.111.023697
language: English
source:
identifier: ISSN: 0002-9165
fulltext: fulltext
issn:
  • 0002-9165
  • 00029165
url: Link


@attributes
ID103136514
RANK0.06999999
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid282326039
sourceidgale_ofa
recordidTN_gale_ofa282326039
sourceformatXML
sourcesystemOther
pqid928748984
galeid282326039
display
typearticle
titleVery-low-calorie diet: a quick therapeutic tool to improve [beta] cell function in morbidly obese patients with type 2 diabetes.(Original Research Communications)(Author abstract)(Report)
creatorMalandrucco, Ilaria ; Pasqualetti, Patrizio ; Giordani, Ilaria ; Manfellotto, Dario ; De Marco, Federica ; Alegiani, Filippo ; Sidoti, Anna Maria ; Picconi, Fabiana ; Flaviani, Alessandra Di ; Frajese, Gaetano ; Bonadonna, Riccardo C. ; Frontoni, Simona
ispartofAmerican Journal of Clinical Nutrition, March, 2012, Vol.95(3), p.609(5)
identifierISSN: 0002-9165
subjectLow Calorie Diet -- Health Aspects ; Low Calorie Diet -- Research ; Obesity -- Risk Factors ; Obesity -- Care And Treatment ; Obesity -- Research ; Type 2 Diabetes -- Complications And Side Effects ; Type 2 Diabetes -- Research
description
languageEnglish
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
scope
0gale_onefilea
1gale_onefileg
2gale_onefilea
3gale_onefileg
4OneFile
creatorcontrib
0Malandrucco, Ilaria
1Malandrucco
2Pasqualetti, Patrizio
3Giordani, Ilaria
4Manfellotto, Dario
5De Marco, Federica
6Alegiani, Filippo
7Sidoti, Anna Maria
8Picconi, Fabiana
9Flaviani, Alessandra Di
10Frajese, Gaetano
11Bonadonna, Riccardo C
12Frontoni, Simona
titleVery-low-calorie diet: a quick therapeutic tool to improve [beta] cell function in morbidly obese patients with type 2 diabetes.(Original Research Communications)(Author abstract)(Report)
description
subject
0Low calorie diet--Health aspects
1Low calorie diet--Research
2Obesity--Risk factors
3Obesity--Care and treatment
4Obesity--Research
5Type 2 diabetes--Complications and side effects
6Type 2 diabetes--Research
7United States
81USA
general
0English
1American Society for Clinical Nutrition, Inc.
2Cengage Learning, Inc.
sourceidgale_ofa
recordidgale_ofa282326039
issn
00002-9165
100029165
rsrctypearticle
creationdate2012
recordtypearticle
addtitleAmerican Journal of Clinical Nutrition
searchscopeOneFile
lsr30VSR-Enriched:[pqid, doi, pages, galeid, eissn]
sort
titleVery-low-calorie diet: a quick therapeutic tool to improve [beta] cell function in morbidly obese patients with type 2 diabetes.(Original Research Communications)(Author abstract)(Report)
authorMalandrucco, Ilaria ; Pasqualetti, Patrizio ; Giordani, Ilaria ; Manfellotto, Dario ; De Marco, Federica ; Alegiani, Filippo ; Sidoti, Anna Maria ; Picconi, Fabiana ; Flaviani, Alessandra Di ; Frajese, Gaetano ; Bonadonna, Riccardo C. ; Frontoni, Simona
creationdate20120301
facets
frbrgroupid9162030741609494070
frbrtype5
languageeng
creationdate2012
topic
0Low Calorie Diet–Health Aspects
1Low Calorie Diet–Research
2Obesity–Risk Factors
3Obesity–Care And Treatment
4Obesity–Research
5Type 2 Diabetes–Complications And Side Effects
6Type 2 Diabetes–Research
collectionOneFile (GALE)
prefilterarticles
rsrctypearticles
creatorcontrib
0Malandrucco, Ilaria
1Pasqualetti, Patrizio
2Giordani, Ilaria
3Manfellotto, Dario
4De Marco, Federica
5Alegiani, Filippo
6Sidoti, Anna Maria
7Picconi, Fabiana
8Flaviani, Alessandra Di
9Frajese, Gaetano
10Bonadonna, Riccardo C.
11Frontoni, Simona
jtitleAmerican Journal of Clinical Nutrition
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Malandrucco, Ilaria
1Pasqualetti, Patrizio
2Giordani, Ilaria
3Manfellotto, Dario
4De Marco, Federica
5Alegiani, Filippo
6Sidoti, Anna Maria
7Picconi, Fabiana
8Flaviani, Alessandra Di
9Frajese, Gaetano
10Bonadonna, Riccardo C.
11Frontoni, Simona
atitleVery-low-calorie diet: a quick therapeutic tool to improve [beta] cell function in morbidly obese patients with type 2 diabetes.(Original Research Communications)(Author abstract)(Report)
jtitleAmerican Journal of Clinical Nutrition
risdate20120301
volume95
issue3
spage609
issn0002-9165
genrearticle
ristypeJOUR
abstract
pubAmerican Society for Clinical Nutrition, Inc.
lad01gale_ofa
doi10.3945/ajcn.111.023697
pages609-60913
eissn19383207
date2012-03-01