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Overexpression of [alpha]CP2, a translational repressor of GAP-43, inhibited axon outgrowth during development in Xenopus laevis.(Report)

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbrc.2012.02.006 Byline: Jing Wang (a), Shenggang Sun (b), Xuebing Cao (b), Xuejun Deng (b), Yunjian Zhang (b), Qing Zhu (b) Keywords: GAP-43; [alpha]CP2; 3'-UTR; Translational repressor; mRNA stability; Axon... Full description

Journal Title: Biochemical and Biophysical Research Communications March 9, 2012, Vol.419(2), p.262(6)
Main Author: Wang, Jing
Other Authors: Sun, Shenggang , Cao, Xuebing , Deng, Xuejun , Zhang, Yunjian , Zhu, Qing
Format: Electronic Article Electronic Article
Language: English
Subjects:
Rna
Quelle: Cengage Learning, Inc.
ID: ISSN: 0006-291X
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title: Overexpression of [alpha]CP2, a translational repressor of GAP-43, inhibited axon outgrowth during development in Xenopus laevis.(Report)
format: Article
creator:
  • Wang, Jing
  • Sun, Shenggang
  • Cao, Xuebing
  • Deng, Xuejun
  • Zhang, Yunjian
  • Zhu, Qing
subjects:
  • Messenger Rna
  • Amphibians
  • Rna
ispartof: Biochemical and Biophysical Research Communications, March 9, 2012, Vol.419(2), p.262(6)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbrc.2012.02.006 Byline: Jing Wang (a), Shenggang Sun (b), Xuebing Cao (b), Xuejun Deng (b), Yunjian Zhang (b), Qing Zhu (b) Keywords: GAP-43; [alpha]CP2; 3'-UTR; Translational repressor; mRNA stability; Axon outgrowth Abstract: a* The 3'-UTR of GAP-43 mRNA in Xenopus laevis contains unique CU-rich sequences. a* [alpha]CP2 was identified as a novel trans factor associated with GAP-43 RNA in vivo. a* [alpha]CP2 translationally inhibited GAP-43 expression without affecting its mRNA stability. a* [alpha]CP2 overexpression inhibited GAP-43 expression and axon outgrowth. Author Affiliation: (a) Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China (b) Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China Article History: Received 31 January 2012
language: English
source: Cengage Learning, Inc.
identifier: ISSN: 0006-291X
fulltext: fulltext
issn:
  • 0006-291X
  • 0006291X
url: Link


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titleOverexpression of [alpha]CP2, a translational repressor of GAP-43, inhibited axon outgrowth during development in Xenopus laevis.(Report)
creatorWang, Jing ; Sun, Shenggang ; Cao, Xuebing ; Deng, Xuejun ; Zhang, Yunjian ; Zhu, Qing
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbrc.2012.02.006 Byline: Jing Wang (a), Shenggang Sun (b), Xuebing Cao (b), Xuejun Deng (b), Yunjian Zhang (b), Qing Zhu (b) Keywords: GAP-43; [alpha]CP2; 3'-UTR; Translational repressor; mRNA stability; Axon outgrowth Abstract: a* The 3'-UTR of GAP-43 mRNA in Xenopus laevis contains unique CU-rich sequences. a* [alpha]CP2 was identified as a novel trans factor associated with GAP-43 RNA in vivo. a* [alpha]CP2 translationally inhibited GAP-43 expression without affecting its mRNA stability. a* [alpha]CP2 overexpression inhibited GAP-43 expression and axon outgrowth. Author Affiliation: (a) Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China (b) Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China Article History: Received 31 January 2012
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titleOverexpression of [alpha]CP2, a translational repressor of GAP-43, inhibited axon outgrowth during development in Xenopus laevis.(Report)
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbrc.2012.02.006 Byline: Jing Wang (a), Shenggang Sun (b), Xuebing Cao (b), Xuejun Deng (b), Yunjian Zhang (b), Qing Zhu (b) Keywords: GAP-43; [alpha]CP2; 3'-UTR; Translational repressor; mRNA stability; Axon outgrowth Abstract: a* The 3'-UTR of GAP-43 mRNA in Xenopus laevis contains unique CU-rich sequences. a* [alpha]CP2 was identified as a novel trans factor associated with GAP-43 RNA in vivo. a* [alpha]CP2 translationally inhibited GAP-43 expression without affecting its mRNA stability. a* [alpha]CP2 overexpression inhibited GAP-43 expression and axon outgrowth. Author Affiliation: (a) Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China (b) Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China Article History: Received 31 January 2012
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abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbrc.2012.02.006 Byline: Jing Wang (a), Shenggang Sun (b), Xuebing Cao (b), Xuejun Deng (b), Yunjian Zhang (b), Qing Zhu (b) Keywords: GAP-43; [alpha]CP2; 3'-UTR; Translational repressor; mRNA stability; Axon outgrowth Abstract: a* The 3'-UTR of GAP-43 mRNA in Xenopus laevis contains unique CU-rich sequences. a* [alpha]CP2 was identified as a novel trans factor associated with GAP-43 RNA in vivo. a* [alpha]CP2 translationally inhibited GAP-43 expression without affecting its mRNA stability. a* [alpha]CP2 overexpression inhibited GAP-43 expression and axon outgrowth. Author Affiliation: (a) Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China (b) Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China Article History: Received 31 January 2012
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