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Functional improvement and neuroplastic effects of anodal transcranial direct current stimulation (tDCS) delivered 1day vs. 1week after cerebral ischemia in rats

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2012.02.062 Byline: Kyung Jae Yoon, Byung-Mo Oh, Dae-Yul Kim Keywords: Cerebral ischemia; Transcranial direct current stimulation; Optimal time window; Plasticity Abstract: Transcranial direct current... Full description

Journal Title: Brain Research May 3, 2012, Vol.1452, p.61(12)
Main Author: Yoon, Kyung Jae
Other Authors: Oh, Byung - Mo , Kim, Dae - Yul
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 0006-8993
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title: Functional improvement and neuroplastic effects of anodal transcranial direct current stimulation (tDCS) delivered 1day vs. 1week after cerebral ischemia in rats
format: Article
creator:
  • Yoon, Kyung Jae
  • Oh, Byung - Mo
  • Kim, Dae - Yul
subjects:
  • Ischemia
  • Cerebral Ischemia
ispartof: Brain Research, May 3, 2012, Vol.1452, p.61(12)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2012.02.062 Byline: Kyung Jae Yoon, Byung-Mo Oh, Dae-Yul Kim Keywords: Cerebral ischemia; Transcranial direct current stimulation; Optimal time window; Plasticity Abstract: Transcranial direct current stimulation (tDCS) is an emerging tool for improving recovery from stroke. However, there has been no trial to determine whether it has a therapeutic benefit in the early stage of cerebral ischemia, and there is no consensus on the optimal time window of stimulation. Here, we described the effects of anodal tDCS in early cerebral ischemia, assessing functional improvements and changes in neuronal plasticity, and identifying the optimal time window for delivering tDCS to maximize functional gains. Thirty rats were randomly assigned to three groups: sham (n=10); early tDCS (ET), receiving tDCS 1day after ischemia for 5days (n=10), and late tDCS (LT), receiving tDCS 1week after ischemia for 5days (n=10). Both ET and LT groups showed improved Barnes maze performance and motor behavioral index scores. However, only the LT group exhibited improvement in beam balance test. Immunohistochemical stainings showed that the ET group reinforced notable MAP-2 expression and the LT group enhanced mainly the level of GAP-43 in both peri-lesional and contralesional cortex. These immunohistochemical results had significant correlation with behavioral and cognitive functions. However, brain MRI and.sup.1H MRS showed no significant differences among the three groups in ischemic volume and metabolic alteration. These results suggest that anodal tDCS has the potential to modulate neural plasticity around the ischemic penumbra and even in the contralesional area without aggravating infarction volume and metabolic alteration. The degree of functional improvement was slightly greater when tDCS was applied 1week rather than 1day after ischemic injury. Article History: Accepted 25 February 2012
language: English
source: Cengage Learning, Inc.
identifier: ISSN: 0006-8993
fulltext: fulltext
issn:
  • 0006-8993
  • 00068993
url: Link


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titleFunctional improvement and neuroplastic effects of anodal transcranial direct current stimulation (tDCS) delivered 1day vs. 1week after cerebral ischemia in rats
creatorYoon, Kyung Jae ; Oh, Byung - Mo ; Kim, Dae - Yul
ispartofBrain Research, May 3, 2012, Vol.1452, p.61(12)
identifierISSN: 0006-8993
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2012.02.062 Byline: Kyung Jae Yoon, Byung-Mo Oh, Dae-Yul Kim Keywords: Cerebral ischemia; Transcranial direct current stimulation; Optimal time window; Plasticity Abstract: Transcranial direct current stimulation (tDCS) is an emerging tool for improving recovery from stroke. However, there has been no trial to determine whether it has a therapeutic benefit in the early stage of cerebral ischemia, and there is no consensus on the optimal time window of stimulation. Here, we described the effects of anodal tDCS in early cerebral ischemia, assessing functional improvements and changes in neuronal plasticity, and identifying the optimal time window for delivering tDCS to maximize functional gains. Thirty rats were randomly assigned to three groups: sham (n=10); early tDCS (ET), receiving tDCS 1day after ischemia for 5days (n=10), and late tDCS (LT), receiving tDCS 1week after ischemia for 5days (n=10). Both ET and LT groups showed improved Barnes maze performance and motor behavioral index scores. However, only the LT group exhibited improvement in beam balance test. Immunohistochemical stainings showed that the ET group reinforced notable MAP-2 expression and the LT group enhanced mainly the level of GAP-43 in both peri-lesional and contralesional cortex. These immunohistochemical results had significant correlation with behavioral and cognitive functions. However, brain MRI and.sup.1H MRS showed no significant differences among the three groups in ischemic volume and metabolic alteration. These results suggest that anodal tDCS has the potential to modulate neural plasticity around the ischemic penumbra and even in the contralesional area without aggravating infarction volume and metabolic alteration. The degree of functional improvement was slightly greater when tDCS was applied 1week rather than 1day after ischemic injury. Article History: Accepted 25 February 2012
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abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2012.02.062 Byline: Kyung Jae Yoon, Byung-Mo Oh, Dae-Yul Kim Keywords: Cerebral ischemia; Transcranial direct current stimulation; Optimal time window; Plasticity Abstract: Transcranial direct current stimulation (tDCS) is an emerging tool for improving recovery from stroke. However, there has been no trial to determine whether it has a therapeutic benefit in the early stage of cerebral ischemia, and there is no consensus on the optimal time window of stimulation. Here, we described the effects of anodal tDCS in early cerebral ischemia, assessing functional improvements and changes in neuronal plasticity, and identifying the optimal time window for delivering tDCS to maximize functional gains. Thirty rats were randomly assigned to three groups: sham (n=10); early tDCS (ET), receiving tDCS 1day after ischemia for 5days (n=10), and late tDCS (LT), receiving tDCS 1week after ischemia for 5days (n=10). Both ET and LT groups showed improved Barnes maze performance and motor behavioral index scores. However, only the LT group exhibited improvement in beam balance test. Immunohistochemical stainings showed that the ET group reinforced notable MAP-2 expression and the LT group enhanced mainly the level of GAP-43 in both peri-lesional and contralesional cortex. These immunohistochemical results had significant correlation with behavioral and cognitive functions. However, brain MRI and.sup.1H MRS showed no significant differences among the three groups in ischemic volume and metabolic alteration. These results suggest that anodal tDCS has the potential to modulate neural plasticity around the ischemic penumbra and even in the contralesional area without aggravating infarction volume and metabolic alteration. The degree of functional improvement was slightly greater when tDCS was applied 1week rather than 1day after ischemic injury. Article History: Accepted 25 February 2012
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