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Association between folate status, diabetes, antihypertensive medication and age-related cataracts in elderly Taiwanese.(Report)

Byline: Kuan-Ju Chen (1,4), W. -H. Pan (2,3), C. -J. Huang (2), Bi-Fong Lin (2,5) Keywords: Folate; diastolic blood pressure; cataract; Elderly Nutrition and Health Survey in Taiwan (1999--2000) Abstract: Objective To evaluate possible risk factors for cataract in elderly Taiwanese, and to investiga... Full description

Journal Title: The Journal of Nutrition Health and Aging, April, 2011, Vol.15(4), p.304(7)
Main Author: Chen, Kuan - Ju
Other Authors: Pan, W. - H. , Huang, C. - J. , Lin, Bi - Fong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1279-7707
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recordid: gale_ofa290615961
title: Association between folate status, diabetes, antihypertensive medication and age-related cataracts in elderly Taiwanese.(Report)
format: Article
creator:
  • Chen, Kuan - Ju
  • Pan, W. - H.
  • Huang, C. - J.
  • Lin, Bi - Fong
subjects:
  • Cataracts -- Risk Factors
  • Cataracts -- Drug Therapy
  • Cataracts -- Analysis
  • Antihypertensive Agents -- Analysis
  • Diabetes Mellitus -- Risk Factors
  • Diabetes Mellitus -- Drug Therapy
  • Diabetes Mellitus -- Analysis
  • Elderly -- Food And Nutrition
  • Elderly -- Analysis
  • Hypertension -- Risk Factors
  • Hypertension -- Drug Therapy
  • Hypertension -- Analysis
  • Folic Acid -- Analysis
  • Drugs -- Analysis
ispartof: The Journal of Nutrition, Health and Aging, April, 2011, Vol.15(4), p.304(7)
description: Byline: Kuan-Ju Chen (1,4), W. -H. Pan (2,3), C. -J. Huang (2), Bi-Fong Lin (2,5) Keywords: Folate; diastolic blood pressure; cataract; Elderly Nutrition and Health Survey in Taiwan (1999--2000) Abstract: Objective To evaluate possible risk factors for cataract in elderly Taiwanese, and to investigate whether the relationship between age and cataract in older persons is modified by other cataract-associated risk factors. Participants A cross-sectional study of 661 males and 645 females aged aY= 65 yrs was conducted as part of the Elderly Nutrition and Health Survey in Taiwan (1999--2000) (Elderly NAHSIT). Methods Self-reported cataracts were defined as any incidence of cataract that was diagnosed by a physician and treated by anticataractic drugs based on the medical history section of the Elderly NAHSIT. Potential risk factors for cataract were determined by multiple logistic regression analysis of data obtained from the health examination, blood biochemistry and interviewer-administered questionnaires. Results Results showed that the prevalence of self-reported cataract increased with age and was significantly higher in older women than in older men. Cataracts were associated with age, diabetes, antihypertensive medication and folate insufficiency in older men, and with age and antihypertensive medication in older women. Folate insufficiency remained associated with cataract in older men who had adequate vitamin B2, B6 and B12 status. Folate insufficiency was associated with cataract after adjustment for other risk factors in older men aged aY= 75 yrs, while in older men aged 65--74 yrs, only diabetes and antihypertensive medication remained associated with cataract. In addition, age aY= 75 yrs remained a risk factor for cataract in those without diabetes, not taking hypertensive medication and with normal folate status. Further analysis showed that the strength of the association between age aY= 75 yrs in older men and cataracts was increased about 1.5-fold when combined with folate insufficiency (interaction p= 0.0198), and increased about 1.8-fold when combined with use of antihypertensive medication (interaction p = 0.0214). Conclusion Our results suggest that the combination of age aY= 75 yrs in older men with either folate insufficiency or use of antihypertensive medication had an additive effect on the risk of cataract. Maintenance of good folate status should be emphasized to reduce the risk of cataract in the Taiwanese elderly, especially men. A
language: English
source:
identifier: ISSN: 1279-7707
fulltext: fulltext
issn:
  • 1279-7707
  • 12797707
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titleAssociation between folate status, diabetes, antihypertensive medication and age-related cataracts in elderly Taiwanese.(Report)
creatorChen, Kuan - Ju ; Pan, W. - H. ; Huang, C. - J. ; Lin, Bi - Fong
ispartofThe Journal of Nutrition, Health and Aging, April, 2011, Vol.15(4), p.304(7)
identifierISSN: 1279-7707
subjectCataracts -- Risk Factors ; Cataracts -- Drug Therapy ; Cataracts -- Analysis ; Antihypertensive Agents -- Analysis ; Diabetes Mellitus -- Risk Factors ; Diabetes Mellitus -- Drug Therapy ; Diabetes Mellitus -- Analysis ; Elderly -- Food And Nutrition ; Elderly -- Analysis ; Hypertension -- Risk Factors ; Hypertension -- Drug Therapy ; Hypertension -- Analysis ; Folic Acid -- Analysis ; Drugs -- Analysis
descriptionByline: Kuan-Ju Chen (1,4), W. -H. Pan (2,3), C. -J. Huang (2), Bi-Fong Lin (2,5) Keywords: Folate; diastolic blood pressure; cataract; Elderly Nutrition and Health Survey in Taiwan (1999--2000) Abstract: Objective To evaluate possible risk factors for cataract in elderly Taiwanese, and to investigate whether the relationship between age and cataract in older persons is modified by other cataract-associated risk factors. Participants A cross-sectional study of 661 males and 645 females aged aY= 65 yrs was conducted as part of the Elderly Nutrition and Health Survey in Taiwan (1999--2000) (Elderly NAHSIT). Methods Self-reported cataracts were defined as any incidence of cataract that was diagnosed by a physician and treated by anticataractic drugs based on the medical history section of the Elderly NAHSIT. Potential risk factors for cataract were determined by multiple logistic regression analysis of data obtained from the health examination, blood biochemistry and interviewer-administered questionnaires. Results Results showed that the prevalence of self-reported cataract increased with age and was significantly higher in older women than in older men. Cataracts were associated with age, diabetes, antihypertensive medication and folate insufficiency in older men, and with age and antihypertensive medication in older women. Folate insufficiency remained associated with cataract in older men who had adequate vitamin B2, B6 and B12 status. Folate insufficiency was associated with cataract after adjustment for other risk factors in older men aged aY= 75 yrs, while in older men aged 65--74 yrs, only diabetes and antihypertensive medication remained associated with cataract. In addition, age aY= 75 yrs remained a risk factor for cataract in those without diabetes, not taking hypertensive medication and with normal folate status. Further analysis showed that the strength of the association between age aY= 75 yrs in older men and cataracts was increased about 1.5-fold when combined with folate insufficiency (interaction p= 0.0198), and increased about 1.8-fold when combined with use of antihypertensive medication (interaction p = 0.0214). Conclusion Our results suggest that the combination of age aY= 75 yrs in older men with either folate insufficiency or use of antihypertensive medication had an additive effect on the risk of cataract. Maintenance of good folate status should be emphasized to reduce the risk of cataract in the Taiwanese elderly, especially men. Author Affiliation: (1) Department of Hospitality Management, Chung-Hwa University of Medical Technology, Tainan, Taiwan, Republic of China (2) Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan, Republic of China (3) Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China (4) No.89, Wen-Hwa 1st ST, Jen-Te Hsiang, Tainan, 717, Taiwan (5) No. 1, Roosevelt Road, Section 4, Taipei, 10617, Taiwan Article History: Registration Date: 07/10/2010 Received Date: 07/03/2010 Accepted Date: 27/03/2010 Online Date: 07/10/2010
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titleAssociation between folate status, diabetes, antihypertensive medication and age-related cataracts in elderly Taiwanese.(Report)
descriptionByline: Kuan-Ju Chen (1,4), W. -H. Pan (2,3), C. -J. Huang (2), Bi-Fong Lin (2,5) Keywords: Folate; diastolic blood pressure; cataract; Elderly Nutrition and Health Survey in Taiwan (1999--2000) Abstract: Objective To evaluate possible risk factors for cataract in elderly Taiwanese, and to investigate whether the relationship between age and cataract in older persons is modified by other cataract-associated risk factors. Participants A cross-sectional study of 661 males and 645 females aged aY= 65 yrs was conducted as part of the Elderly Nutrition and Health Survey in Taiwan (1999--2000) (Elderly NAHSIT). Methods Self-reported cataracts were defined as any incidence of cataract that was diagnosed by a physician and treated by anticataractic drugs based on the medical history section of the Elderly NAHSIT. Potential risk factors for cataract were determined by multiple logistic regression analysis of data obtained from the health examination, blood biochemistry and interviewer-administered questionnaires. Results Results showed that the prevalence of self-reported cataract increased with age and was significantly higher in older women than in older men. Cataracts were associated with age, diabetes, antihypertensive medication and folate insufficiency in older men, and with age and antihypertensive medication in older women. Folate insufficiency remained associated with cataract in older men who had adequate vitamin B2, B6 and B12 status. Folate insufficiency was associated with cataract after adjustment for other risk factors in older men aged aY= 75 yrs, while in older men aged 65--74 yrs, only diabetes and antihypertensive medication remained associated with cataract. In addition, age aY= 75 yrs remained a risk factor for cataract in those without diabetes, not taking hypertensive medication and with normal folate status. Further analysis showed that the strength of the association between age aY= 75 yrs in older men and cataracts was increased about 1.5-fold when combined with folate insufficiency (interaction p= 0.0198), and increased about 1.8-fold when combined with use of antihypertensive medication (interaction p = 0.0214). Conclusion Our results suggest that the combination of age aY= 75 yrs in older men with either folate insufficiency or use of antihypertensive medication had an additive effect on the risk of cataract. Maintenance of good folate status should be emphasized to reduce the risk of cataract in the Taiwanese elderly, especially men. Author Affiliation: (1) Department of Hospitality Management, Chung-Hwa University of Medical Technology, Tainan, Taiwan, Republic of China (2) Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan, Republic of China (3) Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China (4) No.89, Wen-Hwa 1st ST, Jen-Te Hsiang, Tainan, 717, Taiwan (5) No. 1, Roosevelt Road, Section 4, Taipei, 10617, Taiwan Article History: Registration Date: 07/10/2010 Received Date: 07/03/2010 Accepted Date: 27/03/2010 Online Date: 07/10/2010
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1Cataracts--Drug therapy
2Cataracts--Analysis
3Antihypertensive agents--Analysis
4Diabetes mellitus--Risk factors
5Diabetes mellitus--Drug therapy
6Diabetes mellitus--Analysis
7Elderly--Food and nutrition
8Elderly--Analysis
9Hypertension--Risk factors
10Hypertension--Drug therapy
11Hypertension--Analysis
12Folic acid--Analysis
13Drugs--Analysis
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abstractByline: Kuan-Ju Chen (1,4), W. -H. Pan (2,3), C. -J. Huang (2), Bi-Fong Lin (2,5) Keywords: Folate; diastolic blood pressure; cataract; Elderly Nutrition and Health Survey in Taiwan (1999--2000) Abstract: Objective To evaluate possible risk factors for cataract in elderly Taiwanese, and to investigate whether the relationship between age and cataract in older persons is modified by other cataract-associated risk factors. Participants A cross-sectional study of 661 males and 645 females aged aY= 65 yrs was conducted as part of the Elderly Nutrition and Health Survey in Taiwan (1999--2000) (Elderly NAHSIT). Methods Self-reported cataracts were defined as any incidence of cataract that was diagnosed by a physician and treated by anticataractic drugs based on the medical history section of the Elderly NAHSIT. Potential risk factors for cataract were determined by multiple logistic regression analysis of data obtained from the health examination, blood biochemistry and interviewer-administered questionnaires. Results Results showed that the prevalence of self-reported cataract increased with age and was significantly higher in older women than in older men. Cataracts were associated with age, diabetes, antihypertensive medication and folate insufficiency in older men, and with age and antihypertensive medication in older women. Folate insufficiency remained associated with cataract in older men who had adequate vitamin B2, B6 and B12 status. Folate insufficiency was associated with cataract after adjustment for other risk factors in older men aged aY= 75 yrs, while in older men aged 65--74 yrs, only diabetes and antihypertensive medication remained associated with cataract. In addition, age aY= 75 yrs remained a risk factor for cataract in those without diabetes, not taking hypertensive medication and with normal folate status. Further analysis showed that the strength of the association between age aY= 75 yrs in older men and cataracts was increased about 1.5-fold when combined with folate insufficiency (interaction p= 0.0198), and increased about 1.8-fold when combined with use of antihypertensive medication (interaction p = 0.0214). Conclusion Our results suggest that the combination of age aY= 75 yrs in older men with either folate insufficiency or use of antihypertensive medication had an additive effect on the risk of cataract. Maintenance of good folate status should be emphasized to reduce the risk of cataract in the Taiwanese elderly, especially men. Author Affiliation: (1) Department of Hospitality Management, Chung-Hwa University of Medical Technology, Tainan, Taiwan, Republic of China (2) Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan, Republic of China (3) Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China (4) No.89, Wen-Hwa 1st ST, Jen-Te Hsiang, Tainan, 717, Taiwan (5) No. 1, Roosevelt Road, Section 4, Taipei, 10617, Taiwan Article History: Registration Date: 07/10/2010 Received Date: 07/03/2010 Accepted Date: 27/03/2010 Online Date: 07/10/2010
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