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PI4P and PI(4,5)[P.sub.2] are essential but independent lipid determinants of membrane identity.(REPORTS)(Author abstract)(Report)

The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)[P.sub.2]] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)[P.sub.2] synthesis. We... Full description

Journal Title: Science August 10, 2012, Vol.337(6095), p.727(4)
Main Author: Hammond, Gerald R. V.
Other Authors: Fischer, Michael J. , Anderson, Karen E. , Holdich, Jon , Koteci, Ardita , Balla, Tamas , Irvine, Robin F.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0036-8075
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recordid: gale_ofa301555526
title: PI4P and PI(4,5)[P.sub.2] are essential but independent lipid determinants of membrane identity.(REPORTS)(Author abstract)(Report)
format: Article
creator:
  • Hammond, Gerald R. V.
  • Fischer, Michael J.
  • Anderson, Karen E.
  • Holdich, Jon
  • Koteci, Ardita
  • Balla, Tamas
  • Irvine, Robin F.
subjects:
  • Lipids -- Physiological Aspects
  • Cell Membranes -- Physiological Aspects
ispartof: Science, August 10, 2012, Vol.337(6095), p.727(4)
description: The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)[P.sub.2]] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)[P.sub.2] synthesis. We used a combination of pharmacological and chemical genetic approaches to probe the function of PM PI4P, most of which was not required for the synthesis or functions of PI(4,5)[P.sub.2]. However, depletion of both lipids was required to prevent PM targeting of proteins that interact with acidic lipids or activation of the transient receptor potential vanilloid 1 cation channel Therefore, PI4P contributes to the pool of polyanionic lipids that define plasma membrane identity and to some functions previously attributed specifically to PI(4,5)[P.sub.2], which may be fulfilled by a more general polyanionic lipid requirement. 10.1126/science.1222483
language: English
source:
identifier: ISSN: 0036-8075
fulltext: no_fulltext
issn:
  • 0036-8075
  • 00368075
url: Link


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titlePI4P and PI(4,5)[P.sub.2] are essential but independent lipid determinants of membrane identity.(REPORTS)(Author abstract)(Report)
creatorHammond, Gerald R. V. ; Fischer, Michael J. ; Anderson, Karen E. ; Holdich, Jon ; Koteci, Ardita ; Balla, Tamas ; Irvine, Robin F.
ispartofScience, August 10, 2012, Vol.337(6095), p.727(4)
identifierISSN: 0036-8075
subjectLipids -- Physiological Aspects ; Cell Membranes -- Physiological Aspects
descriptionThe quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)[P.sub.2]] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)[P.sub.2] synthesis. We used a combination of pharmacological and chemical genetic approaches to probe the function of PM PI4P, most of which was not required for the synthesis or functions of PI(4,5)[P.sub.2]. However, depletion of both lipids was required to prevent PM targeting of proteins that interact with acidic lipids or activation of the transient receptor potential vanilloid 1 cation channel Therefore, PI4P contributes to the pool of polyanionic lipids that define plasma membrane identity and to some functions previously attributed specifically to PI(4,5)[P.sub.2], which may be fulfilled by a more general polyanionic lipid requirement. 10.1126/science.1222483
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titlePI4P and PI(4,5)[P.sub.2] are essential but independent lipid determinants of membrane identity.(REPORTS)(Author abstract)(Report)
descriptionThe quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)[P.sub.2]] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)[P.sub.2] synthesis. We used a combination of pharmacological and chemical genetic approaches to probe the function of PM PI4P, most of which was not required for the synthesis or functions of PI(4,5)[P.sub.2]. However, depletion of both lipids was required to prevent PM targeting of proteins that interact with acidic lipids or activation of the transient receptor potential vanilloid 1 cation channel Therefore, PI4P contributes to the pool of polyanionic lipids that define plasma membrane identity and to some functions previously attributed specifically to PI(4,5)[P.sub.2], which may be fulfilled by a more general polyanionic lipid requirement. 10.1126/science.1222483
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titlePI4P and PI(4,5)[P.sub.2] are essential but independent lipid determinants of membrane identity.(REPORTS)(Author abstract)(Report)
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abstractThe quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)[P.sub.2]] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)[P.sub.2] synthesis. We used a combination of pharmacological and chemical genetic approaches to probe the function of PM PI4P, most of which was not required for the synthesis or functions of PI(4,5)[P.sub.2]. However, depletion of both lipids was required to prevent PM targeting of proteins that interact with acidic lipids or activation of the transient receptor potential vanilloid 1 cation channel Therefore, PI4P contributes to the pool of polyanionic lipids that define plasma membrane identity and to some functions previously attributed specifically to PI(4,5)[P.sub.2], which may be fulfilled by a more general polyanionic lipid requirement. 10.1126/science.1222483
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