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Direct binding assay for the detection of Type IV allosteric inhibitors of Abl.(Report)

A study of abelson (Abl) tyrosine kinase as an important cellular enzyme that is rendered constitutively active in the breakpoint cluster region (BCR)-Abl fusion protein, contributing to several forms of leukemia is presented. The development of a direct binding assay that enables the straightforwar... Full description

Journal Title: Journal of the American Chemical Society June 6, 2012, Vol.134(22), p.9138-9141
Main Author: Schneider, Ralf
Other Authors: Becker, Christian , Simard, Jeffrey R. , Getlik, Matthaus , Bohlke, Nina , Janning, Petra , Rauh, Daniel
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-7863
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recordid: gale_ofa303184407
title: Direct binding assay for the detection of Type IV allosteric inhibitors of Abl.(Report)
format: Article
creator:
  • Schneider, Ralf
  • Becker, Christian
  • Simard, Jeffrey R.
  • Getlik, Matthaus
  • Bohlke, Nina
  • Janning, Petra
  • Rauh, Daniel
subjects:
  • Binding Sites (Biochemistry) -- Research
  • Drug Interactions -- Research
  • Drug Resistance -- Research
  • Leukemia -- Causes Of
  • Leukemia -- Care And Treatment
  • Antineoplastic Agent Structure-activity Relationships
ispartof: Journal of the American Chemical Society, June 6, 2012, Vol.134(22), p.9138-9141
description: A study of abelson (Abl) tyrosine kinase as an important cellular enzyme that is rendered constitutively active in the breakpoint cluster region (BCR)-Abl fusion protein, contributing to several forms of leukemia is presented. The development of a direct binding assay that enables the straightforward detection of allosteric inhibitors which bind within the myristate pocket of Abl is also reported.
language: English
source:
identifier: ISSN: 0002-7863
fulltext: no_fulltext
issn:
  • 0002-7863
  • 00027863
url: Link


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titleDirect binding assay for the detection of Type IV allosteric inhibitors of Abl.(Report)
creatorSchneider, Ralf ; Becker, Christian ; Simard, Jeffrey R. ; Getlik, Matthaus ; Bohlke, Nina ; Janning, Petra ; Rauh, Daniel
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descriptionA study of abelson (Abl) tyrosine kinase as an important cellular enzyme that is rendered constitutively active in the breakpoint cluster region (BCR)-Abl fusion protein, contributing to several forms of leukemia is presented. The development of a direct binding assay that enables the straightforward detection of allosteric inhibitors which bind within the myristate pocket of Abl is also reported.
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titleDirect binding assay for the detection of Type IV allosteric inhibitors of Abl.(Report)
descriptionA study of abelson (Abl) tyrosine kinase as an important cellular enzyme that is rendered constitutively active in the breakpoint cluster region (BCR)-Abl fusion protein, contributing to several forms of leukemia is presented. The development of a direct binding assay that enables the straightforward detection of allosteric inhibitors which bind within the myristate pocket of Abl is also reported.
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abstractA study of abelson (Abl) tyrosine kinase as an important cellular enzyme that is rendered constitutively active in the breakpoint cluster region (BCR)-Abl fusion protein, contributing to several forms of leukemia is presented. The development of a direct binding assay that enables the straightforward detection of allosteric inhibitors which bind within the myristate pocket of Abl is also reported.
pubAmerican Chemical Society
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date2012-06-06