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Development of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.(Report)(Author abstract)

The rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color cha... Full description

Journal Title: Analytical Chemistry August 7, 2012, Vol.84(15), p.6288(5)
Main Author: Jin - Wu Yan
Other Authors: Wen - Jie Ye , Shuo - Bin Chen , Wei - Bin Wu , Jin - Qiang Hou , Tian - Miao Ou , Jia - Heng Tan , Ding Li , Lian - Quan Gu , Zhi - Shu Huang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0003-2700
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recordid: gale_ofa306254388
title: Development of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.(Report)(Author abstract)
format: Article
creator:
  • Jin - Wu Yan
  • Wen - Jie Ye
  • Shuo - Bin Chen
  • Wei - Bin Wu
  • Jin - Qiang Hou
  • Tian - Miao Ou
  • Jia - Heng Tan
  • Ding Li
  • Lian - Quan Gu
  • Zhi - Shu Huang
subjects:
  • Chemical Synthesis -- Analysis
  • Electron-electron Interactions -- Analysis
  • Thiazoles -- Chemical Properties
  • Thiazoles -- Thermal Properties
ispartof: Analytical Chemistry, August 7, 2012, Vol.84(15), p.6288(5)
description: The rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color change enables label-free visual detection of G-quadruplexes, which is due to the disassembly of dye H-aggregates to monomers. This specific detection of G-quadruplex arises from its end-stacking interaction with G-quartet. On the basis of this universal indicator, a facile approach for large-scale identification of G-quadruplex was developed.
language: English
source:
identifier: ISSN: 0003-2700
fulltext: no_fulltext
issn:
  • 0003-2700
  • 00032700
url: Link


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titleDevelopment of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.(Report)(Author abstract)
creatorJin - Wu Yan ; Wen - Jie Ye ; Shuo - Bin Chen ; Wei - Bin Wu ; Jin - Qiang Hou ; Tian - Miao Ou ; Jia - Heng Tan ; Ding Li ; Lian - Quan Gu ; Zhi - Shu Huang
ispartofAnalytical Chemistry, August 7, 2012, Vol.84(15), p.6288(5)
identifierISSN: 0003-2700
subjectChemical Synthesis -- Analysis ; Electron-electron Interactions -- Analysis ; Thiazoles -- Chemical Properties ; Thiazoles -- Thermal Properties
descriptionThe rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color change enables label-free visual detection of G-quadruplexes, which is due to the disassembly of dye H-aggregates to monomers. This specific detection of G-quadruplex arises from its end-stacking interaction with G-quartet. On the basis of this universal indicator, a facile approach for large-scale identification of G-quadruplex was developed.
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titleDevelopment of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.(Report)(Author abstract)
descriptionThe rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color change enables label-free visual detection of G-quadruplexes, which is due to the disassembly of dye H-aggregates to monomers. This specific detection of G-quadruplex arises from its end-stacking interaction with G-quartet. On the basis of this universal indicator, a facile approach for large-scale identification of G-quadruplex was developed.
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titleDevelopment of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.(Report)(Author abstract)
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abstractThe rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color change enables label-free visual detection of G-quadruplexes, which is due to the disassembly of dye H-aggregates to monomers. This specific detection of G-quadruplex arises from its end-stacking interaction with G-quartet. On the basis of this universal indicator, a facile approach for large-scale identification of G-quadruplex was developed.
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