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Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.09.028 Byline: Xiao-Hong Zhu, James M. Chen, Tsang-Wei Tu, Wei Chen, Sheng-Kwei Song Keywords: In vivo.sup.17O MRS imaging; CMRO.sub.2; CBF; OEF; Stroke Abstract: Many brain diseases have been... Full description

Journal Title: Neuroimage Jan 1, 2013, Vol.64, p.437(11)
Main Author: Zhu, Xiao - Hong
Other Authors: Chen, James M. , Tu, Tsang - Wei , Chen, Wei , Song, Sheng - Kwei
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 1053-8119
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recordid: gale_ofa309944357
title: Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice
format: Article
creator:
  • Zhu, Xiao - Hong
  • Chen, James M.
  • Tu, Tsang - Wei
  • Chen, Wei
  • Song, Sheng - Kwei
subjects:
  • Brain Damage
  • Stroke
  • Diagnostic Imaging
  • Blood Flow
ispartof: Neuroimage, Jan 1, 2013, Vol.64, p.437(11)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.09.028 Byline: Xiao-Hong Zhu, James M. Chen, Tsang-Wei Tu, Wei Chen, Sheng-Kwei Song Keywords: In vivo.sup.17O MRS imaging; CMRO.sub.2; CBF; OEF; Stroke Abstract: Many brain diseases have been linked to abnormal oxygen metabolism and blood perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging cerebral metabolic rate of oxygen (CMRO.sub.2) and cerebral blood flow (CBF), as well as the oxygen extraction fraction (OEF) that reflects the balance between CMRO.sub.2 and CBF. This study employed the recently developed in vivo.sup.17O MR spectroscopic imaging to simultaneously assess CMRO.sub.2, CBF and OEF in the brain using a preclinical middle cerebral arterial occlusion mouse model with a brief inhalation of.sup.17O-labeled oxygen gas. The results demonstrated high sensitivity and reliability of the noninvasive.sup.17O-MR approach for rapidly imaging CMRO.sub.2, CBF and OEF abnormalities in the ischemic cortex of the MCAO mouse brain. It was found that in the ischemic brain regions both CMRO.sub.2 and CBF were substantially lower than that of intact brain regions, even for the mildly damaged brain regions that were unable to be clearly identified by the conventional MRI. In contrast, OEF was higher in the MCAO affected brain regions. This study demonstrates a promising.sup.17O MRI technique for imaging abnormal oxygen metabolism and perfusion in the diseased brain regions. This.sup.17O MRI technique is advantageous because of its robustness, simplicity, noninvasiveness and reliability: features that are essential to potentially translate it to human patients for early diagnosis and monitoring of treatment efficacy. Article History: Accepted 12 September 2012
language: English
source: Cengage Learning, Inc.
identifier: ISSN: 1053-8119
fulltext: fulltext
issn:
  • 1053-8119
  • 10538119
url: Link


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titleSimultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice
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ispartofNeuroimage, Jan 1, 2013, Vol.64, p.437(11)
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.09.028 Byline: Xiao-Hong Zhu, James M. Chen, Tsang-Wei Tu, Wei Chen, Sheng-Kwei Song Keywords: In vivo.sup.17O MRS imaging; CMRO.sub.2; CBF; OEF; Stroke Abstract: Many brain diseases have been linked to abnormal oxygen metabolism and blood perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging cerebral metabolic rate of oxygen (CMRO.sub.2) and cerebral blood flow (CBF), as well as the oxygen extraction fraction (OEF) that reflects the balance between CMRO.sub.2 and CBF. This study employed the recently developed in vivo.sup.17O MR spectroscopic imaging to simultaneously assess CMRO.sub.2, CBF and OEF in the brain using a preclinical middle cerebral arterial occlusion mouse model with a brief inhalation of.sup.17O-labeled oxygen gas. The results demonstrated high sensitivity and reliability of the noninvasive.sup.17O-MR approach for rapidly imaging CMRO.sub.2, CBF and OEF abnormalities in the ischemic cortex of the MCAO mouse brain. It was found that in the ischemic brain regions both CMRO.sub.2 and CBF were substantially lower than that of intact brain regions, even for the mildly damaged brain regions that were unable to be clearly identified by the conventional MRI. In contrast, OEF was higher in the MCAO affected brain regions. This study demonstrates a promising.sup.17O MRI technique for imaging abnormal oxygen metabolism and perfusion in the diseased brain regions. This.sup.17O MRI technique is advantageous because of its robustness, simplicity, noninvasiveness and reliability: features that are essential to potentially translate it to human patients for early diagnosis and monitoring of treatment efficacy. Article History: Accepted 12 September 2012
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abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.09.028 Byline: Xiao-Hong Zhu, James M. Chen, Tsang-Wei Tu, Wei Chen, Sheng-Kwei Song Keywords: In vivo.sup.17O MRS imaging; CMRO.sub.2; CBF; OEF; Stroke Abstract: Many brain diseases have been linked to abnormal oxygen metabolism and blood perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging cerebral metabolic rate of oxygen (CMRO.sub.2) and cerebral blood flow (CBF), as well as the oxygen extraction fraction (OEF) that reflects the balance between CMRO.sub.2 and CBF. This study employed the recently developed in vivo.sup.17O MR spectroscopic imaging to simultaneously assess CMRO.sub.2, CBF and OEF in the brain using a preclinical middle cerebral arterial occlusion mouse model with a brief inhalation of.sup.17O-labeled oxygen gas. The results demonstrated high sensitivity and reliability of the noninvasive.sup.17O-MR approach for rapidly imaging CMRO.sub.2, CBF and OEF abnormalities in the ischemic cortex of the MCAO mouse brain. It was found that in the ischemic brain regions both CMRO.sub.2 and CBF were substantially lower than that of intact brain regions, even for the mildly damaged brain regions that were unable to be clearly identified by the conventional MRI. In contrast, OEF was higher in the MCAO affected brain regions. This study demonstrates a promising.sup.17O MRI technique for imaging abnormal oxygen metabolism and perfusion in the diseased brain regions. This.sup.17O MRI technique is advantageous because of its robustness, simplicity, noninvasiveness and reliability: features that are essential to potentially translate it to human patients for early diagnosis and monitoring of treatment efficacy. Article History: Accepted 12 September 2012
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