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Mediterranean diet and the Spanish paradox. A hypothesis.(Report)

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.mehy.2012.11.015 Byline: Federico Soriguer (a)(b)(c), Eva Garcia-Escobar (a)(b)(c), Sonsoles Morcillo (b), Eduardo Garcia-Fuentes (a)(c), Fernando Rodriguez de Fonseca (d), Gabriel Olveira (a)(b)(c), Gemma Roj... Full description

Journal Title: Medical Hypotheses Feb, 2013, Vol.80(2), p.150(6)
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 0306-9877
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recordid: gale_ofa314710062
title: Mediterranean diet and the Spanish paradox. A hypothesis.(Report)
format: Article
subjects:
  • Mediterranean Diet
ispartof: Medical Hypotheses, Feb, 2013, Vol.80(2), p.150(6)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.mehy.2012.11.015 Byline: Federico Soriguer (a)(b)(c), Eva Garcia-Escobar (a)(b)(c), Sonsoles Morcillo (b), Eduardo Garcia-Fuentes (a)(c), Fernando Rodriguez de Fonseca (d), Gabriel Olveira (a)(b)(c), Gemma Rojo-Martinez (a)(b)(c) Abstract: The Spanish paradox is a phenomenon observed in Spain and some other Mediterranean countries by which the cardiovascular morbidity and mortality levels are dissociated from their cardiovascular risk factors. The Mediterranean diet has been proposed as the main reason for this dissociation, but dietary changes themselves are not enough to explain this situation. It has been recently discovered that Stearoil-CoA desaturase (SCD) is involved in the dissociation between a favourable atherogenic metabolic profile and the risk for arteriosclerosis. We propose a hypothesis that attempts to clarify the Spanish paradox. This hypothesis contemplates the essential role of dietary olive oil and its interaction with different SCD genetic patterns. Confirmation of this hypothesis could provide the basis for the design of clinical and preventive strategies against cardiovascular morbidity and mortality, as well as certain metabolic risk factors. Author Affiliation: (a) Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain (b) CIBERDEM CB07/08/0019 of the Instituto de Salud Carlos III, Spain (c) CIBER of the Pathophysiology of Obesity and Nutrition (CB06/03/0018) of the Instituto de Salud Carlos III, Spain (d) Fundacion IMABIS, Hospital Regional Universitario Carlos Haya, Malaga, Spain Article History: Received 19 January 2012; Accepted 9 November 2012
language: English
source: Cengage Learning, Inc.
identifier: ISSN: 0306-9877
fulltext: fulltext
issn:
  • 0306-9877
  • 03069877
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titleMediterranean diet and the Spanish paradox. A hypothesis.(Report)
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.mehy.2012.11.015 Byline: Federico Soriguer (a)(b)(c), Eva Garcia-Escobar (a)(b)(c), Sonsoles Morcillo (b), Eduardo Garcia-Fuentes (a)(c), Fernando Rodriguez de Fonseca (d), Gabriel Olveira (a)(b)(c), Gemma Rojo-Martinez (a)(b)(c) Abstract: The Spanish paradox is a phenomenon observed in Spain and some other Mediterranean countries by which the cardiovascular morbidity and mortality levels are dissociated from their cardiovascular risk factors. The Mediterranean diet has been proposed as the main reason for this dissociation, but dietary changes themselves are not enough to explain this situation. It has been recently discovered that Stearoil-CoA desaturase (SCD) is involved in the dissociation between a favourable atherogenic metabolic profile and the risk for arteriosclerosis. We propose a hypothesis that attempts to clarify the Spanish paradox. This hypothesis contemplates the essential role of dietary olive oil and its interaction with different SCD genetic patterns. Confirmation of this hypothesis could provide the basis for the design of clinical and preventive strategies against cardiovascular morbidity and mortality, as well as certain metabolic risk factors. Author Affiliation: (a) Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain (b) CIBERDEM CB07/08/0019 of the Instituto de Salud Carlos III, Spain (c) CIBER of the Pathophysiology of Obesity and Nutrition (CB06/03/0018) of the Instituto de Salud Carlos III, Spain (d) Fundacion IMABIS, Hospital Regional Universitario Carlos Haya, Malaga, Spain Article History: Received 19 January 2012; Accepted 9 November 2012
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.mehy.2012.11.015 Byline: Federico Soriguer (a)(b)(c), Eva Garcia-Escobar (a)(b)(c), Sonsoles Morcillo (b), Eduardo Garcia-Fuentes (a)(c), Fernando Rodriguez de Fonseca (d), Gabriel Olveira (a)(b)(c), Gemma Rojo-Martinez (a)(b)(c) Abstract: The Spanish paradox is a phenomenon observed in Spain and some other Mediterranean countries by which the cardiovascular morbidity and mortality levels are dissociated from their cardiovascular risk factors. The Mediterranean diet has been proposed as the main reason for this dissociation, but dietary changes themselves are not enough to explain this situation. It has been recently discovered that Stearoil-CoA desaturase (SCD) is involved in the dissociation between a favourable atherogenic metabolic profile and the risk for arteriosclerosis. We propose a hypothesis that attempts to clarify the Spanish paradox. This hypothesis contemplates the essential role of dietary olive oil and its interaction with different SCD genetic patterns. Confirmation of this hypothesis could provide the basis for the design of clinical and preventive strategies against cardiovascular morbidity and mortality, as well as certain metabolic risk factors. Author Affiliation: (a) Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain (b) CIBERDEM CB07/08/0019 of the Instituto de Salud Carlos III, Spain (c) CIBER of the Pathophysiology of Obesity and Nutrition (CB06/03/0018) of the Instituto de Salud Carlos III, Spain (d) Fundacion IMABIS, Hospital Regional Universitario Carlos Haya, Malaga, Spain Article History: Received 19 January 2012; Accepted 9 November 2012
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abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.mehy.2012.11.015 Byline: Federico Soriguer (a)(b)(c), Eva Garcia-Escobar (a)(b)(c), Sonsoles Morcillo (b), Eduardo Garcia-Fuentes (a)(c), Fernando Rodriguez de Fonseca (d), Gabriel Olveira (a)(b)(c), Gemma Rojo-Martinez (a)(b)(c) Abstract: The Spanish paradox is a phenomenon observed in Spain and some other Mediterranean countries by which the cardiovascular morbidity and mortality levels are dissociated from their cardiovascular risk factors. The Mediterranean diet has been proposed as the main reason for this dissociation, but dietary changes themselves are not enough to explain this situation. It has been recently discovered that Stearoil-CoA desaturase (SCD) is involved in the dissociation between a favourable atherogenic metabolic profile and the risk for arteriosclerosis. We propose a hypothesis that attempts to clarify the Spanish paradox. This hypothesis contemplates the essential role of dietary olive oil and its interaction with different SCD genetic patterns. Confirmation of this hypothesis could provide the basis for the design of clinical and preventive strategies against cardiovascular morbidity and mortality, as well as certain metabolic risk factors. Author Affiliation: (a) Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain (b) CIBERDEM CB07/08/0019 of the Instituto de Salud Carlos III, Spain (c) CIBER of the Pathophysiology of Obesity and Nutrition (CB06/03/0018) of the Instituto de Salud Carlos III, Spain (d) Fundacion IMABIS, Hospital Regional Universitario Carlos Haya, Malaga, Spain Article History: Received 19 January 2012; Accepted 9 November 2012
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