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A naked-eye on-off-on molecular "light switch" based on a reversible "conformational switch" of G-quadruplex DNA.(Report)

Herein, we report a new strategy for developing an on-off-on molecular "light switch" by utilizing the pH value to control the "conformational switch" of G-quadruplex DNA. A novel ruthenium(II) complex with an emission enhancement factor of 150 was synthesized and introduced to detect the switch by... Full description

Journal Title: Inorganic Chemistry Dec 3, 2012, Vol.51(23), p.12591-12593
Main Author: Jun - Liang Yao
Other Authors: Xing Gao , Wenliang Sun , Xue - Zhong Fan , Shuo Shi , Tian - Ming Yao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0020-1669
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recordid: gale_ofa323996505
title: A naked-eye on-off-on molecular "light switch" based on a reversible "conformational switch" of G-quadruplex DNA.(Report)
format: Article
creator:
  • Jun - Liang Yao
  • Xing Gao
  • Wenliang Sun
  • Xue - Zhong Fan
  • Shuo Shi
  • Tian - Ming Yao
subjects:
  • Dna -- Structure
  • Dna -- Genetic Aspects
  • Density Functional Theory -- Usage
  • Fluorescence -- Analysis
  • Ruthenium -- Chemical Properties
  • Ruthenium -- Structure
ispartof: Inorganic Chemistry, Dec 3, 2012, Vol.51(23), p.12591-12593
description: Herein, we report a new strategy for developing an on-off-on molecular "light switch" by utilizing the pH value to control the "conformational switch" of G-quadruplex DNA. A novel ruthenium(II) complex with an emission enhancement factor of 150 was synthesized and introduced to detect the switch by the naked eye. The "light switch" can be repeatedly cycled off and on through the addition of H(+) and OH(-), respectively. The conformational transitions of G-quadruplex DNA in K(+) solution at different pH values in the acidic region were evidenced by circular dichroism and fluorescence titrations. Computational calculations by applying density functional theory (DFT)/time-dependent DFT and molecular docking were also carried out to gain insight into the "light-switch" mechanism.
language: English
source:
identifier: ISSN: 0020-1669
fulltext: fulltext
issn:
  • 0020-1669
  • 00201669
url: Link


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titleA naked-eye on-off-on molecular "light switch" based on a reversible "conformational switch" of G-quadruplex DNA.(Report)
creatorJun - Liang Yao ; Xing Gao ; Wenliang Sun ; Xue - Zhong Fan ; Shuo Shi ; Tian - Ming Yao
ispartofInorganic Chemistry, Dec 3, 2012, Vol.51(23), p.12591-12593
identifierISSN: 0020-1669
subjectDna -- Structure ; Dna -- Genetic Aspects ; Density Functional Theory -- Usage ; Fluorescence -- Analysis ; Ruthenium -- Chemical Properties ; Ruthenium -- Structure
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descriptionHerein, we report a new strategy for developing an on-off-on molecular "light switch" by utilizing the pH value to control the "conformational switch" of G-quadruplex DNA. A novel ruthenium(II) complex with an emission enhancement factor of 150 was synthesized and introduced to detect the switch by the naked eye. The "light switch" can be repeatedly cycled off and on through the addition of H(+) and OH(-), respectively. The conformational transitions of G-quadruplex DNA in K(+) solution at different pH values in the acidic region were evidenced by circular dichroism and fluorescence titrations. Computational calculations by applying density functional theory (DFT)/time-dependent DFT and molecular docking were also carried out to gain insight into the "light-switch" mechanism.
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