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Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals.(Report)

A study demonstrated that ascorbic acid (AA) can enhance Tet-mediated 5-methylcytosine (5mC) oxidation. It was also shown that AA can uniquely interact with the C-terminal catalytic domain of Tet enzymes and promote DNA demethylation in mammals.

Journal Title: Journal of the American Chemical Society July 17, 2013, Vol.135(28), p.10396-10403
Main Author: Ruichuan Yin
Other Authors: Shi - Qing Mao , Bailin Zhao , Zechen Chong , Ying Yang , Chao Zhao , Dapeng Zhang , Hua Huang , Juan Gao , Zheng Li , Yan Jiao , Cuiping Li , Shengquan Liu , Danni Wu , Weikuan Gu , Yun - Gui Yang , Guo - Liang Xu , Hailin Wang
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 0002-7863
Zum Text:
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title: Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals.(Report)
format: Article
creator:
  • Ruichuan Yin
  • Shi - Qing Mao
  • Bailin Zhao
  • Zechen Chong
  • Ying Yang
  • Chao Zhao
  • Dapeng Zhang
  • Hua Huang
  • Juan Gao
  • Zheng Li
  • Yan Jiao
  • Cuiping Li
  • Shengquan Liu
  • Danni Wu
  • Weikuan Gu
  • Yun - Gui Yang
  • Guo - Liang Xu
  • Hailin Wang
subjects:
  • Dna Sequencing -- Research
  • Mammals -- Genetic Aspects
  • Mammals -- Research
  • Methylation -- Analysis
  • Oxidation-reduction Reactions -- Analysis
ispartof: Journal of the American Chemical Society, July 17, 2013, Vol.135(28), p.10396-10403
description: A study demonstrated that ascorbic acid (AA) can enhance Tet-mediated 5-methylcytosine (5mC) oxidation. It was also shown that AA can uniquely interact with the C-terminal catalytic domain of Tet enzymes and promote DNA demethylation in mammals.
language: English
source: Cengage Learning, Inc.
identifier: ISSN: 0002-7863
fulltext: fulltext
issn:
  • 0002-7863
  • 00027863
url: Link


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titleAscorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals.(Report)
creatorRuichuan Yin ; Shi - Qing Mao ; Bailin Zhao ; Zechen Chong ; Ying Yang ; Chao Zhao ; Dapeng Zhang ; Hua Huang ; Juan Gao ; Zheng Li ; Yan Jiao ; Cuiping Li ; Shengquan Liu ; Danni Wu ; Weikuan Gu ; Yun - Gui Yang ; Guo - Liang Xu ; Hailin Wang
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subjectDna Sequencing -- Research ; Mammals -- Genetic Aspects ; Mammals -- Research ; Methylation -- Analysis ; Oxidation-reduction Reactions -- Analysis
descriptionA study demonstrated that ascorbic acid (AA) can enhance Tet-mediated 5-methylcytosine (5mC) oxidation. It was also shown that AA can uniquely interact with the C-terminal catalytic domain of Tet enzymes and promote DNA demethylation in mammals.
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abstractA study demonstrated that ascorbic acid (AA) can enhance Tet-mediated 5-methylcytosine (5mC) oxidation. It was also shown that AA can uniquely interact with the C-terminal catalytic domain of Tet enzymes and promote DNA demethylation in mammals.
pubAmerican Chemical Society
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date2013-07-17