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Impulse oscillometry for leukotriene [D.sub.4] inhalation challenge in asthma.(Report)

BACKGROUND: The value of impulse oscillometry (IOS) for bronchial provocation testing is poorly defined. We investigated the positive threshold derived from the parameters and diagnostic power of IOS for asthma with the leukotriene [D.sub.4] bronchial provocation test. METHODS: We enrolled 62 subjec... Full description

Journal Title: Respiratory Care Dec, 2013, Vol.58(12), p.2120(7)
Main Author: Guan, Wei Jie
Other Authors: Zheng, Jin Ping , Gao, Yi , Jiang, Cai Yu , Shi, Xu , Xie, Yan Qing , Liu, Qing Xia , Jiang, Mei , An, Jia Ying , Yu, Xin Xin , Liu, Wen Ting , Zhong, Li Ping , Wu, Zhong Ping , Zhong, Nan Shan
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 0020-1324
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recordid: gale_ofa352753325
title: Impulse oscillometry for leukotriene [D.sub.4] inhalation challenge in asthma.(Report)
format: Article
creator:
  • Guan, Wei Jie
  • Zheng, Jin Ping
  • Gao, Yi
  • Jiang, Cai Yu
  • Shi, Xu
  • Xie, Yan Qing
  • Liu, Qing Xia
  • Jiang, Mei
  • An, Jia Ying
  • Yu, Xin Xin
  • Liu, Wen Ting
  • Zhong, Li Ping
  • Wu, Zhong Ping
  • Zhong, Nan Shan
subjects:
  • Asthma
ispartof: Respiratory Care, Dec, 2013, Vol.58(12), p.2120(7)
description: BACKGROUND: The value of impulse oscillometry (IOS) for bronchial provocation testing is poorly defined. We investigated the positive threshold derived from the parameters and diagnostic power of IOS for asthma with the leukotriene [D.sub.4] bronchial provocation test. METHODS: We enrolled 62 subjects with asthma and 21 healthy subjects. IOS was employed to perform the leukotriene [D.sub.4] bronchial provocation test, followed by spirometry. The positive threshold was determined based on the cutoff point in the receiver operating characteristic curve, from which the parameters with the highest diagnostic power were obtained. RESULTS: Airway impedance at 5 Hz ([Z.sub.5]), resistance at 5 Hz ([R.sub.5]), and resonance frequency had the highest diagnostic power (areas under curve 0.82, 0.82, and 0.81, respectively), with increases of 57%, 43%, and 63%, corresponding to a 20% decrease in [FEV.sub.1], respectively. IOS indices yielded assay sensitivity and specificity similar to that of spirometry. The positive threshold for IOS, defined as either a 57% increase in [Z.sub.5] or a 63% increase in resonance frequency in the bronchial provocation test, yielded an assay accuracy of 0.6 in subjects with asthma. CONCLUSIONS: IOS during the leukotriene [D.sub.4] bronchial provocation test has a diagnostic power similar to that of spirometry. Either a 57% increase in [Z.sub.5] or a 63% increase in resonance frequency may be regarded as a surrogate of [FEV.sub.1] decrease to determine airway hyper-responsiveness in asthma. Key words: impulse oscillometry; airway resistance; resonance frequency; leukotriene [D.sub.4]; bronchial provocation test; asthma. [Respir Care 2013; 58(12):2120-2126. [C]2013 Daedalus Enterprises]
language: English
source:
identifier: ISSN: 0020-1324
fulltext: fulltext
issn:
  • 0020-1324
  • 00201324
url: Link


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titleImpulse oscillometry for leukotriene [D.sub.4] inhalation challenge in asthma.(Report)
creatorGuan, Wei Jie ; Zheng, Jin Ping ; Gao, Yi ; Jiang, Cai Yu ; Shi, Xu ; Xie, Yan Qing ; Liu, Qing Xia ; Jiang, Mei ; An, Jia Ying ; Yu, Xin Xin ; Liu, Wen Ting ; Zhong, Li Ping ; Wu, Zhong Ping ; Zhong, Nan Shan
ispartofRespiratory Care, Dec, 2013, Vol.58(12), p.2120(7)
identifierISSN: 0020-1324
subjectAsthma
descriptionBACKGROUND: The value of impulse oscillometry (IOS) for bronchial provocation testing is poorly defined. We investigated the positive threshold derived from the parameters and diagnostic power of IOS for asthma with the leukotriene [D.sub.4] bronchial provocation test. METHODS: We enrolled 62 subjects with asthma and 21 healthy subjects. IOS was employed to perform the leukotriene [D.sub.4] bronchial provocation test, followed by spirometry. The positive threshold was determined based on the cutoff point in the receiver operating characteristic curve, from which the parameters with the highest diagnostic power were obtained. RESULTS: Airway impedance at 5 Hz ([Z.sub.5]), resistance at 5 Hz ([R.sub.5]), and resonance frequency had the highest diagnostic power (areas under curve 0.82, 0.82, and 0.81, respectively), with increases of 57%, 43%, and 63%, corresponding to a 20% decrease in [FEV.sub.1], respectively. IOS indices yielded assay sensitivity and specificity similar to that of spirometry. The positive threshold for IOS, defined as either a 57% increase in [Z.sub.5] or a 63% increase in resonance frequency in the bronchial provocation test, yielded an assay accuracy of 0.6 in subjects with asthma. CONCLUSIONS: IOS during the leukotriene [D.sub.4] bronchial provocation test has a diagnostic power similar to that of spirometry. Either a 57% increase in [Z.sub.5] or a 63% increase in resonance frequency may be regarded as a surrogate of [FEV.sub.1] decrease to determine airway hyper-responsiveness in asthma. Key words: impulse oscillometry; airway resistance; resonance frequency; leukotriene [D.sub.4]; bronchial provocation test; asthma. [Respir Care 2013; 58(12):2120-2126. [C]2013 Daedalus Enterprises]
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titleImpulse oscillometry for leukotriene [D.sub.4] inhalation challenge in asthma.(Report)
descriptionBACKGROUND: The value of impulse oscillometry (IOS) for bronchial provocation testing is poorly defined. We investigated the positive threshold derived from the parameters and diagnostic power of IOS for asthma with the leukotriene [D.sub.4] bronchial provocation test. METHODS: We enrolled 62 subjects with asthma and 21 healthy subjects. IOS was employed to perform the leukotriene [D.sub.4] bronchial provocation test, followed by spirometry. The positive threshold was determined based on the cutoff point in the receiver operating characteristic curve, from which the parameters with the highest diagnostic power were obtained. RESULTS: Airway impedance at 5 Hz ([Z.sub.5]), resistance at 5 Hz ([R.sub.5]), and resonance frequency had the highest diagnostic power (areas under curve 0.82, 0.82, and 0.81, respectively), with increases of 57%, 43%, and 63%, corresponding to a 20% decrease in [FEV.sub.1], respectively. IOS indices yielded assay sensitivity and specificity similar to that of spirometry. The positive threshold for IOS, defined as either a 57% increase in [Z.sub.5] or a 63% increase in resonance frequency in the bronchial provocation test, yielded an assay accuracy of 0.6 in subjects with asthma. CONCLUSIONS: IOS during the leukotriene [D.sub.4] bronchial provocation test has a diagnostic power similar to that of spirometry. Either a 57% increase in [Z.sub.5] or a 63% increase in resonance frequency may be regarded as a surrogate of [FEV.sub.1] decrease to determine airway hyper-responsiveness in asthma. Key words: impulse oscillometry; airway resistance; resonance frequency; leukotriene [D.sub.4]; bronchial provocation test; asthma. [Respir Care 2013; 58(12):2120-2126. [C]2013 Daedalus Enterprises]
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titleImpulse oscillometry for leukotriene [D.sub.4] inhalation challenge in asthma.(Report)
authorGuan, Wei Jie ; Zheng, Jin Ping ; Gao, Yi ; Jiang, Cai Yu ; Shi, Xu ; Xie, Yan Qing ; Liu, Qing Xia ; Jiang, Mei ; An, Jia Ying ; Yu, Xin Xin ; Liu, Wen Ting ; Zhong, Li Ping ; Wu, Zhong Ping ; Zhong, Nan Shan
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abstractBACKGROUND: The value of impulse oscillometry (IOS) for bronchial provocation testing is poorly defined. We investigated the positive threshold derived from the parameters and diagnostic power of IOS for asthma with the leukotriene [D.sub.4] bronchial provocation test. METHODS: We enrolled 62 subjects with asthma and 21 healthy subjects. IOS was employed to perform the leukotriene [D.sub.4] bronchial provocation test, followed by spirometry. The positive threshold was determined based on the cutoff point in the receiver operating characteristic curve, from which the parameters with the highest diagnostic power were obtained. RESULTS: Airway impedance at 5 Hz ([Z.sub.5]), resistance at 5 Hz ([R.sub.5]), and resonance frequency had the highest diagnostic power (areas under curve 0.82, 0.82, and 0.81, respectively), with increases of 57%, 43%, and 63%, corresponding to a 20% decrease in [FEV.sub.1], respectively. IOS indices yielded assay sensitivity and specificity similar to that of spirometry. The positive threshold for IOS, defined as either a 57% increase in [Z.sub.5] or a 63% increase in resonance frequency in the bronchial provocation test, yielded an assay accuracy of 0.6 in subjects with asthma. CONCLUSIONS: IOS during the leukotriene [D.sub.4] bronchial provocation test has a diagnostic power similar to that of spirometry. Either a 57% increase in [Z.sub.5] or a 63% increase in resonance frequency may be regarded as a surrogate of [FEV.sub.1] decrease to determine airway hyper-responsiveness in asthma. Key words: impulse oscillometry; airway resistance; resonance frequency; leukotriene [D.sub.4]; bronchial provocation test; asthma. [Respir Care 2013; 58(12):2120-2126. [C]2013 Daedalus Enterprises]
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