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Meta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children.(Report)

Byline: Shan Li (1), Xiu-li Huang (1), Jing-zhe Sui (1), Si-yuan Chen (2), Yan-tong Xie (3), Yan Deng (1), Jian Wang (1), Li Xie (1), Tai-jie Li (1), Yu He (1), Qi-liu Peng (1), Xue Qin (1), Zhi-yu Zeng (4) Keywords: Helicobacter pylori; Eradication; Probiotics; Children Abstract: The efficacy of pr... Full description

Journal Title: European Journal of Pediatrics Feb, 2014, Vol.173(2), p.153(9)
Main Author: Li, Shan
Other Authors: Huang, Xiu - Li , Sui, Jing - Zhe , Chen, Si - Yuan , Xie, Yan - Tong , Deng, Yan , Wang, Jian , Xie, Li , Li, Tai - Jie , He, Yu , Peng, Qi - Liu , Qin, Xue , Zeng, Zhi - Yu
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Language: English
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ID: ISSN: 0340-6199
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title: Meta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children.(Report)
format: Article
creator:
  • Li, Shan
  • Huang, Xiu - Li
  • Sui, Jing - Zhe
  • Chen, Si - Yuan
  • Xie, Yan - Tong
  • Deng, Yan
  • Wang, Jian
  • Xie, Li
  • Li, Tai - Jie
  • He, Yu
  • Peng, Qi - Liu
  • Qin, Xue
  • Zeng, Zhi - Yu
subjects:
  • Helicobacter Pylori -- Analysis
  • Child Health -- Analysis
  • Helicobacter Infections -- Analysis
  • Medical Schools -- Analysis
  • Children -- Analysis
ispartof: European Journal of Pediatrics, Feb, 2014, Vol.173(2), p.153(9)
description: Byline: Shan Li (1), Xiu-li Huang (1), Jing-zhe Sui (1), Si-yuan Chen (2), Yan-tong Xie (3), Yan Deng (1), Jian Wang (1), Li Xie (1), Tai-jie Li (1), Yu He (1), Qi-liu Peng (1), Xue Qin (1), Zhi-yu Zeng (4) Keywords: Helicobacter pylori; Eradication; Probiotics; Children Abstract: The efficacy of probiotics supplementation in children undergoing Helicobacter pylori (H. pylori) eradication therapy remains controversial. This study aimed to meta-analyze whether probiotics supplementation in triple therapy could improve H. pylori eradication rates and reduce therapy-related side effects in children. Electronic databases PubMed and Embase were searched to identify all randomized controlled trials in pediatric patients comparing probiotics supplementation with placebo or no extra intervention in H. pylori eradication therapy. Two authors independently extracted the data. Results were expressed as odds ratios (ORs) and accompanying 95 % confidence intervals (CIs). Stata version 12.0 was used to perform all statistical analyses. Seven studies consisting of 508 pediatric patients were included in our study. The pooled ORs (studies n=7) of eradication rates by intention-to-treat and per-protocol analysis in the probiotics group versus the control group were 1.96 (95 % CI 1.28--3.02) and 2.25 (95 % CI 1.41--3.57), respectively. The pooled OR (studies n=5) of incidence of total side effects was 0.32 (95 % CI 0.13--0.79), with significant heterogeneity observed (I .sup.2=71.9 %). Conclusion: Probiotics supplementation in triple therapy for H. pylori infection may have beneficial effects on eradication and therapy-related side effects, particularly diarrhea, in children. Author Affiliation: (1) Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China (2) Guangxi University of Chinese Medicine, Nanning, 530001, Guangxi, China (3) Guangxi Medical University, Nanning, 530021, Guangxi, China (4) Department of Geriatrics, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China Article History: Registration Date: 20/11/2013 Received Date: 07/09/2013 Accepted Date: 20/11/2013 Online Date: 10/12/2013 Article note: Shan Li, Xiu-li Huang, and Jing-zhe Sui contributed equally to this work and should be considered as co-first authors.
language: English
source:
identifier: ISSN: 0340-6199
fulltext: fulltext
issn:
  • 0340-6199
  • 03406199
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titleMeta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children.(Report)
creatorLi, Shan ; Huang, Xiu - Li ; Sui, Jing - Zhe ; Chen, Si - Yuan ; Xie, Yan - Tong ; Deng, Yan ; Wang, Jian ; Xie, Li ; Li, Tai - Jie ; He, Yu ; Peng, Qi - Liu ; Qin, Xue ; Zeng, Zhi - Yu
ispartofEuropean Journal of Pediatrics, Feb, 2014, Vol.173(2), p.153(9)
identifierISSN: 0340-6199
subjectHelicobacter Pylori -- Analysis ; Child Health -- Analysis ; Helicobacter Infections -- Analysis ; Medical Schools -- Analysis ; Children -- Analysis
descriptionByline: Shan Li (1), Xiu-li Huang (1), Jing-zhe Sui (1), Si-yuan Chen (2), Yan-tong Xie (3), Yan Deng (1), Jian Wang (1), Li Xie (1), Tai-jie Li (1), Yu He (1), Qi-liu Peng (1), Xue Qin (1), Zhi-yu Zeng (4) Keywords: Helicobacter pylori; Eradication; Probiotics; Children Abstract: The efficacy of probiotics supplementation in children undergoing Helicobacter pylori (H. pylori) eradication therapy remains controversial. This study aimed to meta-analyze whether probiotics supplementation in triple therapy could improve H. pylori eradication rates and reduce therapy-related side effects in children. Electronic databases PubMed and Embase were searched to identify all randomized controlled trials in pediatric patients comparing probiotics supplementation with placebo or no extra intervention in H. pylori eradication therapy. Two authors independently extracted the data. Results were expressed as odds ratios (ORs) and accompanying 95 % confidence intervals (CIs). Stata version 12.0 was used to perform all statistical analyses. Seven studies consisting of 508 pediatric patients were included in our study. The pooled ORs (studies n=7) of eradication rates by intention-to-treat and per-protocol analysis in the probiotics group versus the control group were 1.96 (95 % CI 1.28--3.02) and 2.25 (95 % CI 1.41--3.57), respectively. The pooled OR (studies n=5) of incidence of total side effects was 0.32 (95 % CI 0.13--0.79), with significant heterogeneity observed (I .sup.2=71.9 %). Conclusion: Probiotics supplementation in triple therapy for H. pylori infection may have beneficial effects on eradication and therapy-related side effects, particularly diarrhea, in children. Author Affiliation: (1) Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China (2) Guangxi University of Chinese Medicine, Nanning, 530001, Guangxi, China (3) Guangxi Medical University, Nanning, 530021, Guangxi, China (4) Department of Geriatrics, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China Article History: Registration Date: 20/11/2013 Received Date: 07/09/2013 Accepted Date: 20/11/2013 Online Date: 10/12/2013 Article note: Shan Li, Xiu-li Huang, and Jing-zhe Sui contributed equally to this work and should be considered as co-first authors.
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titleMeta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children.(Report)
descriptionByline: Shan Li (1), Xiu-li Huang (1), Jing-zhe Sui (1), Si-yuan Chen (2), Yan-tong Xie (3), Yan Deng (1), Jian Wang (1), Li Xie (1), Tai-jie Li (1), Yu He (1), Qi-liu Peng (1), Xue Qin (1), Zhi-yu Zeng (4) Keywords: Helicobacter pylori; Eradication; Probiotics; Children Abstract: The efficacy of probiotics supplementation in children undergoing Helicobacter pylori (H. pylori) eradication therapy remains controversial. This study aimed to meta-analyze whether probiotics supplementation in triple therapy could improve H. pylori eradication rates and reduce therapy-related side effects in children. Electronic databases PubMed and Embase were searched to identify all randomized controlled trials in pediatric patients comparing probiotics supplementation with placebo or no extra intervention in H. pylori eradication therapy. Two authors independently extracted the data. Results were expressed as odds ratios (ORs) and accompanying 95 % confidence intervals (CIs). Stata version 12.0 was used to perform all statistical analyses. Seven studies consisting of 508 pediatric patients were included in our study. The pooled ORs (studies n=7) of eradication rates by intention-to-treat and per-protocol analysis in the probiotics group versus the control group were 1.96 (95 % CI 1.28--3.02) and 2.25 (95 % CI 1.41--3.57), respectively. The pooled OR (studies n=5) of incidence of total side effects was 0.32 (95 % CI 0.13--0.79), with significant heterogeneity observed (I .sup.2=71.9 %). Conclusion: Probiotics supplementation in triple therapy for H. pylori infection may have beneficial effects on eradication and therapy-related side effects, particularly diarrhea, in children. Author Affiliation: (1) Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China (2) Guangxi University of Chinese Medicine, Nanning, 530001, Guangxi, China (3) Guangxi Medical University, Nanning, 530021, Guangxi, China (4) Department of Geriatrics, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China Article History: Registration Date: 20/11/2013 Received Date: 07/09/2013 Accepted Date: 20/11/2013 Online Date: 10/12/2013 Article note: Shan Li, Xiu-li Huang, and Jing-zhe Sui contributed equally to this work and should be considered as co-first authors.
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titleMeta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children.(Report)
authorLi, Shan ; Huang, Xiu - Li ; Sui, Jing - Zhe ; Chen, Si - Yuan ; Xie, Yan - Tong ; Deng, Yan ; Wang, Jian ; Xie, Li ; Li, Tai - Jie ; He, Yu ; Peng, Qi - Liu ; Qin, Xue ; Zeng, Zhi - Yu
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abstractByline: Shan Li (1), Xiu-li Huang (1), Jing-zhe Sui (1), Si-yuan Chen (2), Yan-tong Xie (3), Yan Deng (1), Jian Wang (1), Li Xie (1), Tai-jie Li (1), Yu He (1), Qi-liu Peng (1), Xue Qin (1), Zhi-yu Zeng (4) Keywords: Helicobacter pylori; Eradication; Probiotics; Children Abstract: The efficacy of probiotics supplementation in children undergoing Helicobacter pylori (H. pylori) eradication therapy remains controversial. This study aimed to meta-analyze whether probiotics supplementation in triple therapy could improve H. pylori eradication rates and reduce therapy-related side effects in children. Electronic databases PubMed and Embase were searched to identify all randomized controlled trials in pediatric patients comparing probiotics supplementation with placebo or no extra intervention in H. pylori eradication therapy. Two authors independently extracted the data. Results were expressed as odds ratios (ORs) and accompanying 95 % confidence intervals (CIs). Stata version 12.0 was used to perform all statistical analyses. Seven studies consisting of 508 pediatric patients were included in our study. The pooled ORs (studies n=7) of eradication rates by intention-to-treat and per-protocol analysis in the probiotics group versus the control group were 1.96 (95 % CI 1.28--3.02) and 2.25 (95 % CI 1.41--3.57), respectively. The pooled OR (studies n=5) of incidence of total side effects was 0.32 (95 % CI 0.13--0.79), with significant heterogeneity observed (I .sup.2=71.9 %). Conclusion: Probiotics supplementation in triple therapy for H. pylori infection may have beneficial effects on eradication and therapy-related side effects, particularly diarrhea, in children. Author Affiliation: (1) Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China (2) Guangxi University of Chinese Medicine, Nanning, 530001, Guangxi, China (3) Guangxi Medical University, Nanning, 530021, Guangxi, China (4) Department of Geriatrics, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China Article History: Registration Date: 20/11/2013 Received Date: 07/09/2013 Accepted Date: 20/11/2013 Online Date: 10/12/2013 Article note: Shan Li, Xiu-li Huang, and Jing-zhe Sui contributed equally to this work and should be considered as co-first authors.
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