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Resonance characteristic and its ionic basis of rat mesencephalic trigeminal neurons

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.10.064 Byline: Jing Yang, Sanjue Hu, Fujun Li, Junling Xing Abstract: Intrinsic resonant frequency properties of neurons in the brain provide a basis for different behavioral states and determine... Full description

Journal Title: Brain Research Jan 30, Vol.1596, p.1(12)
Main Author: Yang, Jing
Other Authors: Hu, Sanjue , Li, Fujun , Xing, Junling
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 0006-8993
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recordid: gale_ofa396804888
title: Resonance characteristic and its ionic basis of rat mesencephalic trigeminal neurons
format: Article
creator:
  • Yang, Jing
  • Hu, Sanjue
  • Li, Fujun
  • Xing, Junling
subjects:
  • Neurons
  • Neurosciences
  • Military Hospitals
ispartof: Brain Research, Jan 30, Vol.1596, p.1(12)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.10.064 Byline: Jing Yang, Sanjue Hu, Fujun Li, Junling Xing Abstract: Intrinsic resonant frequency properties of neurons in the brain provide a basis for different behavioral states and determine the responding modality (i.e. excitability) of different neurons. Previously, three types of excitability behaviors in rat Mesencephalic V neurons were found. To investigate the different resonant frequency and ionic current mechanisms underlying different resonances among three types of excitability, we performed whole-cell patch recordings and applied ZAP current on Mesencephalic V cells (N=70) in rat slices. The results show that: Class 2 neurons (30/30) have two resonances with U-shaped voltage dependence. One is a high frequency resonance (75.4[+ or -]2.11Hz) significant at depolarized potentials (about -50mV) and the other is a low frequency resonance (5.46[+ or -]0.31Hz) significant at hyperpolarized potentials (about -70mV). Voltage clamp experiments reveal two non-inactivating currents operating in the subthreshold voltage range: (1) 4-aminopyridine sensitive K.sup.+ current, which activates at membrane potentials positive than -60mV and was blocked by 4-AP (50[micro]M), was underlying the high frequency resonance of Class 2 neuron; (2) h-current, which activates negative than -60mV and was blocked by the hyperpolarization-activated cyclic nucleotide-gated channel blocker ZD7288 (10[micro]M), was underlying the low frequency resonance. Class 1 neurons do not show voltage-dependence resonant behaviors (10/10). Class 3 neurons (23/30) have two resonances, which are similar with Class 2 in both resonant frequency and currents. Our results provide clear evidence for the existence of multiple kinds of frequency resonances and how the relationship between the resonant frequency and the ionic current is based in Mesencephalic V neurons. Author Affiliation: (a) The 323 Military Hospital, 6 West Jian-she Road, Xi'an 710054, P.R. China (b) Institute of Neuroscience, The Fourth Military Medical University, 17 Chang-le West Road, Xi'an 710032, P.R. China Article History: Accepted 28 October 2014 Article Note: (footnote) [star] This work was supported by the National Natural Science Foundation of China (Nos. 31271185, 81371241, 81470060) and Military Medical Science and Technology Research Project (No. CLZ13JB19).
language: eng
source: Cengage Learning, Inc.
identifier: ISSN: 0006-8993
fulltext: fulltext
issn:
  • 0006-8993
  • 00068993
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.10.064 Byline: Jing Yang, Sanjue Hu, Fujun Li, Junling Xing Abstract: Intrinsic resonant frequency properties of neurons in the brain provide a basis for different behavioral states and determine the responding modality (i.e. excitability) of different neurons. Previously, three types of excitability behaviors in rat Mesencephalic V neurons were found. To investigate the different resonant frequency and ionic current mechanisms underlying different resonances among three types of excitability, we performed whole-cell patch recordings and applied ZAP current on Mesencephalic V cells (N=70) in rat slices. The results show that: Class 2 neurons (30/30) have two resonances with U-shaped voltage dependence. One is a high frequency resonance (75.4[+ or -]2.11Hz) significant at depolarized potentials (about -50mV) and the other is a low frequency resonance (5.46[+ or -]0.31Hz) significant at hyperpolarized potentials (about -70mV). Voltage clamp experiments reveal two non-inactivating currents operating in the subthreshold voltage range: (1) 4-aminopyridine sensitive K.sup.+ current, which activates at membrane potentials positive than -60mV and was blocked by 4-AP (50[micro]M), was underlying the high frequency resonance of Class 2 neuron; (2) h-current, which activates negative than -60mV and was blocked by the hyperpolarization-activated cyclic nucleotide-gated channel blocker ZD7288 (10[micro]M), was underlying the low frequency resonance. Class 1 neurons do not show voltage-dependence resonant behaviors (10/10). Class 3 neurons (23/30) have two resonances, which are similar with Class 2 in both resonant frequency and currents. Our results provide clear evidence for the existence of multiple kinds of frequency resonances and how the relationship between the resonant frequency and the ionic current is based in Mesencephalic V neurons. Author Affiliation: (a) The 323 Military Hospital, 6 West Jian-she Road, Xi'an 710054, P.R. China (b) Institute of Neuroscience, The Fourth Military Medical University, 17 Chang-le West Road, Xi'an 710032, P.R. China Article History: Accepted 28 October 2014 Article Note: (footnote) [star] This work was supported by the National Natural Science Foundation of China (Nos. 31271185, 81371241, 81470060) and Military Medical Science and Technology Research Project (No. CLZ13JB19).
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.10.064 Byline: Jing Yang, Sanjue Hu, Fujun Li, Junling Xing Abstract: Intrinsic resonant frequency properties of neurons in the brain provide a basis for different behavioral states and determine the responding modality (i.e. excitability) of different neurons. Previously, three types of excitability behaviors in rat Mesencephalic V neurons were found. To investigate the different resonant frequency and ionic current mechanisms underlying different resonances among three types of excitability, we performed whole-cell patch recordings and applied ZAP current on Mesencephalic V cells (N=70) in rat slices. The results show that: Class 2 neurons (30/30) have two resonances with U-shaped voltage dependence. One is a high frequency resonance (75.4[+ or -]2.11Hz) significant at depolarized potentials (about -50mV) and the other is a low frequency resonance (5.46[+ or -]0.31Hz) significant at hyperpolarized potentials (about -70mV). Voltage clamp experiments reveal two non-inactivating currents operating in the subthreshold voltage range: (1) 4-aminopyridine sensitive K.sup.+ current, which activates at membrane potentials positive than -60mV and was blocked by 4-AP (50[micro]M), was underlying the high frequency resonance of Class 2 neuron; (2) h-current, which activates negative than -60mV and was blocked by the hyperpolarization-activated cyclic nucleotide-gated channel blocker ZD7288 (10[micro]M), was underlying the low frequency resonance. Class 1 neurons do not show voltage-dependence resonant behaviors (10/10). Class 3 neurons (23/30) have two resonances, which are similar with Class 2 in both resonant frequency and currents. Our results provide clear evidence for the existence of multiple kinds of frequency resonances and how the relationship between the resonant frequency and the ionic current is based in Mesencephalic V neurons. Author Affiliation: (a) The 323 Military Hospital, 6 West Jian-she Road, Xi'an 710054, P.R. China (b) Institute of Neuroscience, The Fourth Military Medical University, 17 Chang-le West Road, Xi'an 710032, P.R. China Article History: Accepted 28 October 2014 Article Note: (footnote) [star] This work was supported by the National Natural Science Foundation of China (Nos. 31271185, 81371241, 81470060) and Military Medical Science and Technology Research Project (No. CLZ13JB19).
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abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.10.064 Byline: Jing Yang, Sanjue Hu, Fujun Li, Junling Xing Abstract: Intrinsic resonant frequency properties of neurons in the brain provide a basis for different behavioral states and determine the responding modality (i.e. excitability) of different neurons. Previously, three types of excitability behaviors in rat Mesencephalic V neurons were found. To investigate the different resonant frequency and ionic current mechanisms underlying different resonances among three types of excitability, we performed whole-cell patch recordings and applied ZAP current on Mesencephalic V cells (N=70) in rat slices. The results show that: Class 2 neurons (30/30) have two resonances with U-shaped voltage dependence. One is a high frequency resonance (75.4[+ or -]2.11Hz) significant at depolarized potentials (about -50mV) and the other is a low frequency resonance (5.46[+ or -]0.31Hz) significant at hyperpolarized potentials (about -70mV). Voltage clamp experiments reveal two non-inactivating currents operating in the subthreshold voltage range: (1) 4-aminopyridine sensitive K.sup.+ current, which activates at membrane potentials positive than -60mV and was blocked by 4-AP (50[micro]M), was underlying the high frequency resonance of Class 2 neuron; (2) h-current, which activates negative than -60mV and was blocked by the hyperpolarization-activated cyclic nucleotide-gated channel blocker ZD7288 (10[micro]M), was underlying the low frequency resonance. Class 1 neurons do not show voltage-dependence resonant behaviors (10/10). Class 3 neurons (23/30) have two resonances, which are similar with Class 2 in both resonant frequency and currents. Our results provide clear evidence for the existence of multiple kinds of frequency resonances and how the relationship between the resonant frequency and the ionic current is based in Mesencephalic V neurons. Author Affiliation: (a) The 323 Military Hospital, 6 West Jian-she Road, Xi'an 710054, P.R. China (b) Institute of Neuroscience, The Fourth Military Medical University, 17 Chang-le West Road, Xi'an 710032, P.R. China Article History: Accepted 28 October 2014 Article Note: (footnote) [star] This work was supported by the National Natural Science Foundation of China (Nos. 31271185, 81371241, 81470060) and Military Medical Science and Technology Research Project (No. CLZ13JB19).
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