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Live cell integrated surface plasmon resonance biosensing approach to mimic the regulation of angiogenic switch upon anti-cancer drug exposure.(Report)

The article describes a novel surface plasmon resonance (SPR) based live-cell biosensing platform for measuring and comparing the binding affinity of vascular endothelial growth factor (VEGF) to vascular endothelial growth factor receptor (VEGFR) and VEGF to bevacizumab. It is found that bevacizumab... Full description

Journal Title: Analytical Chemistry August 5, Vol.86(15), p.7305(6)
Main Author: Chang Liu
Other Authors: Alwarappan, Subbiah , Badr, Haitham A. , Rui Zhang , Hongyun Liu , Jun-Jie Zhu , Chen-Zhong Li
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0003-2700
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recordid: gale_ofa397531495
title: Live cell integrated surface plasmon resonance biosensing approach to mimic the regulation of angiogenic switch upon anti-cancer drug exposure.(Report)
format: Article
creator:
  • Chang Liu
  • Alwarappan, Subbiah
  • Badr, Haitham A.
  • Rui Zhang
  • Hongyun Liu
  • Jun-Jie Zhu
  • Chen-Zhong Li
subjects:
  • Antineoplastic Agents – Research
  • Enzyme Binding – Research
  • Protein Synthesis – Research
  • Surface Plasmon Resonance – Analysis
ispartof: Analytical Chemistry, August 5, Vol.86(15), p.7305(6)
description: The article describes a novel surface plasmon resonance (SPR) based live-cell biosensing platform for measuring and comparing the binding affinity of vascular endothelial growth factor (VEGF) to vascular endothelial growth factor receptor (VEGFR) and VEGF to bevacizumab. It is found that bevacizumab binds VEGF with a higher association rate and affinity compared to VEGFR. Moreover, the monitoring of the competitive binding to VEGF between VEGFR and bevacizumab demonstrates a significant blockage of VEGFuVEGFR binding by bevacizumab.
language: eng
source:
identifier: ISSN: 0003-2700
fulltext: fulltext
issn:
  • 0003-2700
  • 00032700
url: Link


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titleLive cell integrated surface plasmon resonance biosensing approach to mimic the regulation of angiogenic switch upon anti-cancer drug exposure.(Report)
creatorChang Liu ; Alwarappan, Subbiah ; Badr, Haitham A. ; Rui Zhang ; Hongyun Liu ; Jun-Jie Zhu ; Chen-Zhong Li
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subjectAntineoplastic Agents – Research ; Enzyme Binding – Research ; Protein Synthesis – Research ; Surface Plasmon Resonance – Analysis
descriptionThe article describes a novel surface plasmon resonance (SPR) based live-cell biosensing platform for measuring and comparing the binding affinity of vascular endothelial growth factor (VEGF) to vascular endothelial growth factor receptor (VEGFR) and VEGF to bevacizumab. It is found that bevacizumab binds VEGF with a higher association rate and affinity compared to VEGFR. Moreover, the monitoring of the competitive binding to VEGF between VEGFR and bevacizumab demonstrates a significant blockage of VEGFuVEGFR binding by bevacizumab.
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titleLive cell integrated surface plasmon resonance biosensing approach to mimic the regulation of angiogenic switch upon anti-cancer drug exposure.(Report)
descriptionThe article describes a novel surface plasmon resonance (SPR) based live-cell biosensing platform for measuring and comparing the binding affinity of vascular endothelial growth factor (VEGF) to vascular endothelial growth factor receptor (VEGFR) and VEGF to bevacizumab. It is found that bevacizumab binds VEGF with a higher association rate and affinity compared to VEGFR. Moreover, the monitoring of the competitive binding to VEGF between VEGFR and bevacizumab demonstrates a significant blockage of VEGFuVEGFR binding by bevacizumab.
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abstractThe article describes a novel surface plasmon resonance (SPR) based live-cell biosensing platform for measuring and comparing the binding affinity of vascular endothelial growth factor (VEGF) to vascular endothelial growth factor receptor (VEGFR) and VEGF to bevacizumab. It is found that bevacizumab binds VEGF with a higher association rate and affinity compared to VEGFR. Moreover, the monitoring of the competitive binding to VEGF between VEGFR and bevacizumab demonstrates a significant blockage of VEGFuVEGFR binding by bevacizumab.
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atitleLive cell integrated surface plasmon resonance biosensing approach to mimic the regulation of angiogenic switch upon anti-cancer drug exposure.
volume86
issue15
issn0003-2700
pubAmerican Chemical Society
doi10.1021/ac402659j
pages7305
eissn15206882
date2014-08-05