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Magnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness.(Report)

Byline: James Thomas Patrick Decourcy Hallinan (1), Hind Saif Alsaif (1,2), Aileen Wee (3), Sudhakar Kundapur Venkatesh (4) Keywords: Magnetic resonance elastography; Liver fibrosis; Intravenous Gd-DTPA; Liver stiffness Abstract: Purpose To evaluate the effect of intravenous gadolinium-diethylenetri... Full description

Journal Title: Abdominal Imaging 2015, Vol.40(4), p.783(6)
Main Author: Hallinan, James Thomas Patrick Decourcy
Other Authors: Alsaif, Hind Saif , Wee, Aileen , Venkatesh, Sudhakar Kundapur
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0942-8925
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title: Magnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness.(Report)
format: Article
creator:
  • Hallinan, James Thomas Patrick Decourcy
  • Alsaif, Hind Saif
  • Wee, Aileen
  • Venkatesh, Sudhakar Kundapur
subjects:
  • Acetic Acid
  • Gadolinium
  • Rare Earth Metal Compounds
  • Liver
  • Organic Acids
  • Liver Diseases
ispartof: Abdominal Imaging, 2015, Vol.40(4), p.783(6)
description: Byline: James Thomas Patrick Decourcy Hallinan (1), Hind Saif Alsaif (1,2), Aileen Wee (3), Sudhakar Kundapur Venkatesh (4) Keywords: Magnetic resonance elastography; Liver fibrosis; Intravenous Gd-DTPA; Liver stiffness Abstract: Purpose To evaluate the effect of intravenous gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) on estimation of liver stiffness using magnetic resonance elastography (MRE) for detection of liver fibrosis. Materials and methods Liver MRI with MRE was performed in 210 subjects on a single 1.5 Tesla clinical MRI scanner. Liver MRE was performed before intravenous Gd-DTPA injection (NC-MRE) and 5 minutes post injection (PC-MRE) using a modified phase-contrast gradient-echo sequence (TR/TE=100/27ms, FOV=30-46cm, 4x10mm slices, gap 5mm) which automatically generated stiffness maps. Two readers' blinded to clinical details independently performed liver stiffness measurements (LSM) by drawing 2 or more regions of interest (ROI) on the stiffness maps on each of the four slices of NC-MRE and PC-MRE obtained for each patient. The mean LSM in kilopascals (kPa) for NC-MRE and PC-MRE was calculated. The correlation between NC-MRE and PC-MRE LSM was evaluated with a paired t test and Pearson's correlation analysis, and the inter-observer correlation was evaluated using intra class coefficient (ICC) analysis. A receiver operating curve analysis (ROC) was performed to compare accuracies for detection and staging of liver fibrosis in a subgroup of 72 subjects with histological confirmation of liver fibrosis. Results There was an excellent correlation between NC-MRE and PC-MRE LSM (R.sup.2=0.98, p
language: eng
source:
identifier: ISSN: 0942-8925
fulltext: no_fulltext
issn:
  • 0942-8925
  • 09428925
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titleMagnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness.(Report)
creatorHallinan, James Thomas Patrick Decourcy ; Alsaif, Hind Saif ; Wee, Aileen ; Venkatesh, Sudhakar Kundapur
ispartofAbdominal Imaging, 2015, Vol.40(4), p.783(6)
identifierISSN: 0942-8925
subjectAcetic Acid ; Gadolinium ; Rare Earth Metal Compounds ; Liver ; Organic Acids ; Liver Diseases
descriptionByline: James Thomas Patrick Decourcy Hallinan (1), Hind Saif Alsaif (1,2), Aileen Wee (3), Sudhakar Kundapur Venkatesh (4) Keywords: Magnetic resonance elastography; Liver fibrosis; Intravenous Gd-DTPA; Liver stiffness Abstract: Purpose To evaluate the effect of intravenous gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) on estimation of liver stiffness using magnetic resonance elastography (MRE) for detection of liver fibrosis. Materials and methods Liver MRI with MRE was performed in 210 subjects on a single 1.5 Tesla clinical MRI scanner. Liver MRE was performed before intravenous Gd-DTPA injection (NC-MRE) and 5 minutes post injection (PC-MRE) using a modified phase-contrast gradient-echo sequence (TR/TE=100/27ms, FOV=30-46cm, 4x10mm slices, gap 5mm) which automatically generated stiffness maps. Two readers' blinded to clinical details independently performed liver stiffness measurements (LSM) by drawing 2 or more regions of interest (ROI) on the stiffness maps on each of the four slices of NC-MRE and PC-MRE obtained for each patient. The mean LSM in kilopascals (kPa) for NC-MRE and PC-MRE was calculated. The correlation between NC-MRE and PC-MRE LSM was evaluated with a paired t test and Pearson's correlation analysis, and the inter-observer correlation was evaluated using intra class coefficient (ICC) analysis. A receiver operating curve analysis (ROC) was performed to compare accuracies for detection and staging of liver fibrosis in a subgroup of 72 subjects with histological confirmation of liver fibrosis. Results There was an excellent correlation between NC-MRE and PC-MRE LSM (R.sup.2=0.98, p<0.001) with no significant differences. The interobserver agreement was also excellent (ICC, 0.94-0.99). There were no significant differences in the cut-off LSM value/accuracy/sensitivity/specificity for detection of significant liver fibrosis with NC-MRE and PC-MRE (2.98kPa/98.5%/100%/88%, p<0.001 and 3.1kPa/98.2%/98%/88%, p<0.001 respectively). Conclusion Intravenous Gd-DTPA had no significant influence on LSM with MRE and does not significantly affect the diagnostic performance of MRE for fibrosis detection. Author Affiliation: (1) Diagnostic Imaging, National University Health System, Singapore, Singapore (2) Radiology, King Fahd Hospital of the University, Dammam University, College of Medicine, Alkhobar, Saudi Arabia (3) Department of Pathology, National University Health System, Singapore, Singapore (4) Department of Radiology, Mayo Clinic, Rochester, 200, First Street SW, Rochester, MN, 55905, USA Article History: Registration Date: 13/10/2014 Online Date: 21/10/2014
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titleMagnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness.(Report)
descriptionByline: James Thomas Patrick Decourcy Hallinan (1), Hind Saif Alsaif (1,2), Aileen Wee (3), Sudhakar Kundapur Venkatesh (4) Keywords: Magnetic resonance elastography; Liver fibrosis; Intravenous Gd-DTPA; Liver stiffness Abstract: Purpose To evaluate the effect of intravenous gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) on estimation of liver stiffness using magnetic resonance elastography (MRE) for detection of liver fibrosis. Materials and methods Liver MRI with MRE was performed in 210 subjects on a single 1.5 Tesla clinical MRI scanner. Liver MRE was performed before intravenous Gd-DTPA injection (NC-MRE) and 5 minutes post injection (PC-MRE) using a modified phase-contrast gradient-echo sequence (TR/TE=100/27ms, FOV=30-46cm, 4x10mm slices, gap 5mm) which automatically generated stiffness maps. Two readers' blinded to clinical details independently performed liver stiffness measurements (LSM) by drawing 2 or more regions of interest (ROI) on the stiffness maps on each of the four slices of NC-MRE and PC-MRE obtained for each patient. The mean LSM in kilopascals (kPa) for NC-MRE and PC-MRE was calculated. The correlation between NC-MRE and PC-MRE LSM was evaluated with a paired t test and Pearson's correlation analysis, and the inter-observer correlation was evaluated using intra class coefficient (ICC) analysis. A receiver operating curve analysis (ROC) was performed to compare accuracies for detection and staging of liver fibrosis in a subgroup of 72 subjects with histological confirmation of liver fibrosis. Results There was an excellent correlation between NC-MRE and PC-MRE LSM (R.sup.2=0.98, p<0.001) with no significant differences. The interobserver agreement was also excellent (ICC, 0.94-0.99). There were no significant differences in the cut-off LSM value/accuracy/sensitivity/specificity for detection of significant liver fibrosis with NC-MRE and PC-MRE (2.98kPa/98.5%/100%/88%, p<0.001 and 3.1kPa/98.2%/98%/88%, p<0.001 respectively). Conclusion Intravenous Gd-DTPA had no significant influence on LSM with MRE and does not significantly affect the diagnostic performance of MRE for fibrosis detection. Author Affiliation: (1) Diagnostic Imaging, National University Health System, Singapore, Singapore (2) Radiology, King Fahd Hospital of the University, Dammam University, College of Medicine, Alkhobar, Saudi Arabia (3) Department of Pathology, National University Health System, Singapore, Singapore (4) Department of Radiology, Mayo Clinic, Rochester, 200, First Street SW, Rochester, MN, 55905, USA Article History: Registration Date: 13/10/2014 Online Date: 21/10/2014
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9Industrial inorganic chemicals, not elsewhere classified
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titleMagnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness.(Report)
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abstractByline: James Thomas Patrick Decourcy Hallinan (1), Hind Saif Alsaif (1,2), Aileen Wee (3), Sudhakar Kundapur Venkatesh (4) Keywords: Magnetic resonance elastography; Liver fibrosis; Intravenous Gd-DTPA; Liver stiffness Abstract: Purpose To evaluate the effect of intravenous gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) on estimation of liver stiffness using magnetic resonance elastography (MRE) for detection of liver fibrosis. Materials and methods Liver MRI with MRE was performed in 210 subjects on a single 1.5 Tesla clinical MRI scanner. Liver MRE was performed before intravenous Gd-DTPA injection (NC-MRE) and 5 minutes post injection (PC-MRE) using a modified phase-contrast gradient-echo sequence (TR/TE=100/27ms, FOV=30-46cm, 4x10mm slices, gap 5mm) which automatically generated stiffness maps. Two readers' blinded to clinical details independently performed liver stiffness measurements (LSM) by drawing 2 or more regions of interest (ROI) on the stiffness maps on each of the four slices of NC-MRE and PC-MRE obtained for each patient. The mean LSM in kilopascals (kPa) for NC-MRE and PC-MRE was calculated. The correlation between NC-MRE and PC-MRE LSM was evaluated with a paired t test and Pearson's correlation analysis, and the inter-observer correlation was evaluated using intra class coefficient (ICC) analysis. A receiver operating curve analysis (ROC) was performed to compare accuracies for detection and staging of liver fibrosis in a subgroup of 72 subjects with histological confirmation of liver fibrosis. Results There was an excellent correlation between NC-MRE and PC-MRE LSM (R.sup.2=0.98, p<0.001) with no significant differences. The interobserver agreement was also excellent (ICC, 0.94-0.99). There were no significant differences in the cut-off LSM value/accuracy/sensitivity/specificity for detection of significant liver fibrosis with NC-MRE and PC-MRE (2.98kPa/98.5%/100%/88%, p<0.001 and 3.1kPa/98.2%/98%/88%, p<0.001 respectively). Conclusion Intravenous Gd-DTPA had no significant influence on LSM with MRE and does not significantly affect the diagnostic performance of MRE for fibrosis detection. Author Affiliation: (1) Diagnostic Imaging, National University Health System, Singapore, Singapore (2) Radiology, King Fahd Hospital of the University, Dammam University, College of Medicine, Alkhobar, Saudi Arabia (3) Department of Pathology, National University Health System, Singapore, Singapore (4) Department of Radiology, Mayo Clinic, Rochester, 200, First Street SW, Rochester, MN, 55905, USA Article History: Registration Date: 13/10/2014 Online Date: 21/10/2014
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atitleMagnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness.
volume40
issue4
issn0942-8925
pubSpringer
doi10.1007/s00261-014-0275-x
pages783-788
eissn14320509
date2015-04-01