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Deferoxamine alleviates chronic hydrocephalus after intraventricular hemorrhage through iron chelation and Wnt1/Wnt3a inhibition

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.08.039 Byline: Hui Meng, Fei Li, Rong Hu, Yikai Yuan, Guoqi Gong, Shengli Hu, Hua Feng Abstract: Post-hemorrhagic chronic hydrocephalus (PHCH) is a common complication after intraventricular hemo... Full description

Journal Title: Brain Research March 30, 2015, Vol.1602, p.44(9)
Main Author: Meng, Hui
Other Authors: Li, Fei , Hu, Rong , Yuan, Yikai , Gong, Guoqi , Hu, Shengli , Feng, Hua
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 0006-8993 ; DOI: 10.1016/j.brainres.2014.08.039
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recordid: gale_ofa407697875
title: Deferoxamine alleviates chronic hydrocephalus after intraventricular hemorrhage through iron chelation and Wnt1/Wnt3a inhibition
format: Article
creator:
  • Meng, Hui
  • Li, Fei
  • Hu, Rong
  • Yuan, Yikai
  • Gong, Guoqi
  • Hu, Shengli
  • Feng, Hua
subjects:
  • Hydrocephalus – Analysis
  • Intraventricular Hemorrhage – Analysis
  • Ferritin – Analysis
  • Gene Expression – Analysis
ispartof: Brain Research, March 30, 2015, Vol.1602, p.44(9)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.08.039 Byline: Hui Meng, Fei Li, Rong Hu, Yikai Yuan, Guoqi Gong, Shengli Hu, Hua Feng Abstract: Post-hemorrhagic chronic hydrocephalus (PHCH) is a common complication after intraventricular hemorrhage (IVH). The mechanism of PHCH is not fully understood, and its treatment is relatively difficult. In the present study, a rat model of PHCH was used to elucidate the role of iron in the pathogenesis of PHCH. The action of deferoxamine (DFX) in IVH-induced PHCH, the expression of brain ferritin, the concentration of iron in cerebrospinal fluid (CSF), and changes in Wnt1/Wnt3a gene expression were determined. Results indicate that iron plays an important role in the occurrence of hydrocephalus after IVH. The iron chelator, DFX, can decrease the concentrations of iron and ferritin after cerebral hemorrhage and can thereby decrease the incidence of hydrocephalus. In addition, after IVH, the gene expression of Wnt1 and Wnt3a was enhanced, with protein expression also upregulated; DFX was able to suppress both gene and protein expression of Wnt1 and Wnt3a in brain tissue. This indicates that iron may be the key stimulus that activates the Wnt signaling pathway and regulates subarachnoid fibrosis after cerebral hemorrhage, and that DFX may be a candidate for preventing PHCH in patients with IVH. Author Affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, GaoTanYan Street, ShaPingBa, Chongqing 400038, China Article History: Accepted 14 August 2014
language: eng
source: Cengage Learning, Inc.
identifier: ISSN: 0006-8993 ; DOI: 10.1016/j.brainres.2014.08.039
fulltext: fulltext
issn:
  • 0006-8993
  • 00068993
url: Link


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titleDeferoxamine alleviates chronic hydrocephalus after intraventricular hemorrhage through iron chelation and Wnt1/Wnt3a inhibition
creatorMeng, Hui ; Li, Fei ; Hu, Rong ; Yuan, Yikai ; Gong, Guoqi ; Hu, Shengli ; Feng, Hua
ispartofBrain Research, March 30, 2015, Vol.1602, p.44(9)
identifierISSN: 0006-8993 ; DOI: 10.1016/j.brainres.2014.08.039
subjectHydrocephalus – Analysis ; Intraventricular Hemorrhage – Analysis ; Ferritin – Analysis ; Gene Expression – Analysis
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.08.039 Byline: Hui Meng, Fei Li, Rong Hu, Yikai Yuan, Guoqi Gong, Shengli Hu, Hua Feng Abstract: Post-hemorrhagic chronic hydrocephalus (PHCH) is a common complication after intraventricular hemorrhage (IVH). The mechanism of PHCH is not fully understood, and its treatment is relatively difficult. In the present study, a rat model of PHCH was used to elucidate the role of iron in the pathogenesis of PHCH. The action of deferoxamine (DFX) in IVH-induced PHCH, the expression of brain ferritin, the concentration of iron in cerebrospinal fluid (CSF), and changes in Wnt1/Wnt3a gene expression were determined. Results indicate that iron plays an important role in the occurrence of hydrocephalus after IVH. The iron chelator, DFX, can decrease the concentrations of iron and ferritin after cerebral hemorrhage and can thereby decrease the incidence of hydrocephalus. In addition, after IVH, the gene expression of Wnt1 and Wnt3a was enhanced, with protein expression also upregulated; DFX was able to suppress both gene and protein expression of Wnt1 and Wnt3a in brain tissue. This indicates that iron may be the key stimulus that activates the Wnt signaling pathway and regulates subarachnoid fibrosis after cerebral hemorrhage, and that DFX may be a candidate for preventing PHCH in patients with IVH. Author Affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, GaoTanYan Street, ShaPingBa, Chongqing 400038, China Article History: Accepted 14 August 2014
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titleDeferoxamine alleviates chronic hydrocephalus after intraventricular hemorrhage through iron chelation and Wnt1/Wnt3a inhibition.
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.08.039 Byline: Hui Meng, Fei Li, Rong Hu, Yikai Yuan, Guoqi Gong, Shengli Hu, Hua Feng Abstract: Post-hemorrhagic chronic hydrocephalus (PHCH) is a common complication after intraventricular hemorrhage (IVH). The mechanism of PHCH is not fully understood, and its treatment is relatively difficult. In the present study, a rat model of PHCH was used to elucidate the role of iron in the pathogenesis of PHCH. The action of deferoxamine (DFX) in IVH-induced PHCH, the expression of brain ferritin, the concentration of iron in cerebrospinal fluid (CSF), and changes in Wnt1/Wnt3a gene expression were determined. Results indicate that iron plays an important role in the occurrence of hydrocephalus after IVH. The iron chelator, DFX, can decrease the concentrations of iron and ferritin after cerebral hemorrhage and can thereby decrease the incidence of hydrocephalus. In addition, after IVH, the gene expression of Wnt1 and Wnt3a was enhanced, with protein expression also upregulated; DFX was able to suppress both gene and protein expression of Wnt1 and Wnt3a in brain tissue. This indicates that iron may be the key stimulus that activates the Wnt signaling pathway and regulates subarachnoid fibrosis after cerebral hemorrhage, and that DFX may be a candidate for preventing PHCH in patients with IVH. Author Affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, GaoTanYan Street, ShaPingBa, Chongqing 400038, China Article History: Accepted 14 August 2014
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abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2014.08.039 Byline: Hui Meng, Fei Li, Rong Hu, Yikai Yuan, Guoqi Gong, Shengli Hu, Hua Feng Abstract: Post-hemorrhagic chronic hydrocephalus (PHCH) is a common complication after intraventricular hemorrhage (IVH). The mechanism of PHCH is not fully understood, and its treatment is relatively difficult. In the present study, a rat model of PHCH was used to elucidate the role of iron in the pathogenesis of PHCH. The action of deferoxamine (DFX) in IVH-induced PHCH, the expression of brain ferritin, the concentration of iron in cerebrospinal fluid (CSF), and changes in Wnt1/Wnt3a gene expression were determined. Results indicate that iron plays an important role in the occurrence of hydrocephalus after IVH. The iron chelator, DFX, can decrease the concentrations of iron and ferritin after cerebral hemorrhage and can thereby decrease the incidence of hydrocephalus. In addition, after IVH, the gene expression of Wnt1 and Wnt3a was enhanced, with protein expression also upregulated; DFX was able to suppress both gene and protein expression of Wnt1 and Wnt3a in brain tissue. This indicates that iron may be the key stimulus that activates the Wnt signaling pathway and regulates subarachnoid fibrosis after cerebral hemorrhage, and that DFX may be a candidate for preventing PHCH in patients with IVH. Author Affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, GaoTanYan Street, ShaPingBa, Chongqing 400038, China Article History: Accepted 14 August 2014
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