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Quantification of voxel-wise total fibre density: Investigating the problems associated with track-count mapping

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2015.05.070 Byline: Fernando Calamante, Robert E. Smith, Jacques-Donald Tournier, David Raffelt, Alan Connelly Abstract: A biological parameter that would be valuable to be able to extract from diff... Full description

Journal Title: Neuroimage August 15, 2015, Vol.117, p.284(10)
Main Author: Calamante, Fernando
Other Authors: Smith, Robert E. , Tournier, Jacques-Donald , Raffelt, David , Connelly, Alan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 1053-8119
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recordid: gale_ofa423865071
title: Quantification of voxel-wise total fibre density: Investigating the problems associated with track-count mapping
format: Article
creator:
  • Calamante, Fernando
  • Smith, Robert E.
  • Tournier, Jacques-Donald
  • Raffelt, David
  • Connelly, Alan
subjects:
  • Deer Hunting – Investigations
  • Density – Investigations
ispartof: Neuroimage, August 15, 2015, Vol.117, p.284(10)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2015.05.070 Byline: Fernando Calamante, Robert E. Smith, Jacques-Donald Tournier, David Raffelt, Alan Connelly Abstract: A biological parameter that would be valuable to be able to extract from diffusion MRI data is the local white matter axonal density. Track-density imaging (TDI) has been used as if it could provide such a measure; however, this has been the subject of controversy, primarily due to the fact that track-count quantitation is highly sensitive to tracking biases and errors. The spherical-deconvolution informed filtering of tractograms (SIFT) post-processing method was recently introduced to minimise tractography biases, and thus provides a more biologically meaningful measure that could be used in track-count mapping (i.e. TDI following SIFT). The TDI intensity following SIFT ideally corresponds to the orientational average of the fibre orientation distribution (FOD), which corresponds to the total Apparent Fibre Density (AFD.sub.total) within the AFD framework; in fact, AFD.sub.total provides a direct measure of local fibre density at native resolution that does not rely on fibre-tracking. In this study, we demonstrate problems associated with quantitative TDI investigations, which can be avoided by using SIFT processing or directly by using AFD.sub.total maps. We also characterise the intra- and inter-subject reproducibility of TDI maps (with and without SIFT pre-processing) and AFD.sub.total maps. It is shown that SIFT improves the quantitative characteristics of TDI, but is still vastly inferior to the properties of the AFD.sub.total parameter itself, because the latter does not require tracking. While standard TDI might be preferable in applications when high anatomical contrast is required, particularly when combined with super-resolution, for voxel-wise quantitation of total tract density (i.e. without tract orientation information) at native resolution, the total AFD maps are preferable to TDI or other related track-count maps. Regardless of the track-count measure, it should be noted that all of these voxel-averaged approaches discard important information that is retained in fibre-specific approaches such as AFD. Article History: Received 17 February 2015; Accepted 24 May 2015
language: eng
source: Cengage Learning, Inc.
identifier: ISSN: 1053-8119
fulltext: fulltext
issn:
  • 1053-8119
  • 10538119
url: Link


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titleQuantification of voxel-wise total fibre density: Investigating the problems associated with track-count mapping
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identifierISSN: 1053-8119
subjectDeer Hunting – Investigations ; Density – Investigations
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2015.05.070 Byline: Fernando Calamante, Robert E. Smith, Jacques-Donald Tournier, David Raffelt, Alan Connelly Abstract: A biological parameter that would be valuable to be able to extract from diffusion MRI data is the local white matter axonal density. Track-density imaging (TDI) has been used as if it could provide such a measure; however, this has been the subject of controversy, primarily due to the fact that track-count quantitation is highly sensitive to tracking biases and errors. The spherical-deconvolution informed filtering of tractograms (SIFT) post-processing method was recently introduced to minimise tractography biases, and thus provides a more biologically meaningful measure that could be used in track-count mapping (i.e. TDI following SIFT). The TDI intensity following SIFT ideally corresponds to the orientational average of the fibre orientation distribution (FOD), which corresponds to the total Apparent Fibre Density (AFD.sub.total) within the AFD framework; in fact, AFD.sub.total provides a direct measure of local fibre density at native resolution that does not rely on fibre-tracking. In this study, we demonstrate problems associated with quantitative TDI investigations, which can be avoided by using SIFT processing or directly by using AFD.sub.total maps. We also characterise the intra- and inter-subject reproducibility of TDI maps (with and without SIFT pre-processing) and AFD.sub.total maps. It is shown that SIFT improves the quantitative characteristics of TDI, but is still vastly inferior to the properties of the AFD.sub.total parameter itself, because the latter does not require tracking. While standard TDI might be preferable in applications when high anatomical contrast is required, particularly when combined with super-resolution, for voxel-wise quantitation of total tract density (i.e. without tract orientation information) at native resolution, the total AFD maps are preferable to TDI or other related track-count maps. Regardless of the track-count measure, it should be noted that all of these voxel-averaged approaches discard important information that is retained in fibre-specific approaches such as AFD. Article History: Received 17 February 2015; Accepted 24 May 2015
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abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2015.05.070 Byline: Fernando Calamante, Robert E. Smith, Jacques-Donald Tournier, David Raffelt, Alan Connelly Abstract: A biological parameter that would be valuable to be able to extract from diffusion MRI data is the local white matter axonal density. Track-density imaging (TDI) has been used as if it could provide such a measure; however, this has been the subject of controversy, primarily due to the fact that track-count quantitation is highly sensitive to tracking biases and errors. The spherical-deconvolution informed filtering of tractograms (SIFT) post-processing method was recently introduced to minimise tractography biases, and thus provides a more biologically meaningful measure that could be used in track-count mapping (i.e. TDI following SIFT). The TDI intensity following SIFT ideally corresponds to the orientational average of the fibre orientation distribution (FOD), which corresponds to the total Apparent Fibre Density (AFD.sub.total) within the AFD framework; in fact, AFD.sub.total provides a direct measure of local fibre density at native resolution that does not rely on fibre-tracking. In this study, we demonstrate problems associated with quantitative TDI investigations, which can be avoided by using SIFT processing or directly by using AFD.sub.total maps. We also characterise the intra- and inter-subject reproducibility of TDI maps (with and without SIFT pre-processing) and AFD.sub.total maps. It is shown that SIFT improves the quantitative characteristics of TDI, but is still vastly inferior to the properties of the AFD.sub.total parameter itself, because the latter does not require tracking. While standard TDI might be preferable in applications when high anatomical contrast is required, particularly when combined with super-resolution, for voxel-wise quantitation of total tract density (i.e. without tract orientation information) at native resolution, the total AFD maps are preferable to TDI or other related track-count maps. Regardless of the track-count measure, it should be noted that all of these voxel-averaged approaches discard important information that is retained in fibre-specific approaches such as AFD. Article History: Received 17 February 2015; Accepted 24 May 2015
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