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A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity.(Research Article)(Report)(Author abstract)

Background. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR. Methods. To determine CR's feasibility, safety, and effects on predictors of longevity, d... Full description

Journal Title: The Journals of Gerontology Series A, 2015, Vol.70(9), p.1097(8)
Main Author: Ravussin, Eric
Other Authors: Redman, Leanne M. , Rochon, James , Das, Sai Krupa , Fontana, Luigi , Kraus, William E. , Romashkan, Sergei , Williamson, Donald A. , Meydani, Simin N. , Villareal, Dennis T. , Smith, Steven R. , Stein, Richard I. , Scott, Tammy M. , Stewart, Tiffany M. , Saltzman, Edward , Klein, Samuel , Bhapkar, Manju , Martin, Corby K. , Gilhooly, Cheryl H. , Holloszy, John O. , Hadley, Evan C. , Roberts, Susan B.
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 1079-5006
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recordid: gale_ofa428356888
title: A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity.(Research Article)(Report)(Author abstract)
format: Article
creator:
  • Ravussin, Eric
  • Redman, Leanne M.
  • Rochon, James
  • Das, Sai Krupa
  • Fontana, Luigi
  • Kraus, William E.
  • Romashkan, Sergei
  • Williamson, Donald A.
  • Meydani, Simin N.
  • Villareal, Dennis T.
  • Smith, Steven R.
  • Stein, Richard I.
  • Scott, Tammy M.
  • Stewart, Tiffany M.
  • Saltzman, Edward
  • Klein, Samuel
  • Bhapkar, Manju
  • Martin, Corby K.
  • Gilhooly, Cheryl H.
  • Holloszy, John O.
  • Hadley, Evan C.
  • Roberts, Susan B.
subjects:
  • Low Calorie Diet – Research
  • Life Span (Biology) – Research
ispartof: The Journals of Gerontology, Series A, 2015, Vol.70(9), p.1097(8)
description: Background. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR. Methods. To determine CR's feasibility, safety, and effects on predictors of longevity, disease risk factors, and quality of life in nonobese humans aged 21-51 years, 218 persons were randomized to a 2-year intervention designed to achieve 25% CR or to AL diet. Outcomes were change from baseline resting metabolic rate adjusted for weight change ("RMR residual") and core temperature (primary); plasma triiodothyronine (T3) and tumor necrosis factor-[alpha] (secondary); and exploratory physiological and psychological measures. Results. Body mass index averaged 25.1 (range: 21.9-28.0kg/[m.sup.2]). Eighty-two percent of CR and 95% of AL participants completed the protocol. The CR group achieved 11.7[+ or -]0.7 %CR (mean [+ or -] standard error) and maintained 10.4[+ or -]0.4% weight loss. Weight change in AL was negligible. RMR residual decreased significantly more in CR than AL at 12 months (p = .04) but not 24 months (M24). Core temperature change differed little between groups. T3 decreased more in CR at M12 and M24 (p < .001), while tumor necrosis factor-a decreased significantly more only at M24 (p = .02). CR had larger decreases in cardiometabolic risk factors and in daily energy expenditure adjusted for weight change, without adverse effects on quality of life. Conclusions. Sustained CR is feasible in nonobese humans. The effects of the achieved CR on correlates of human survival and disease risk factors suggest potential benefits for aging-related outcomes that could be elucidated by further human studies. Key Words: Metabolism--Nutrition--Risk factors--Biomarkers--Caloric restriction doi:10.1093/gerona/glv057
language: eng
source:
identifier: ISSN: 1079-5006
fulltext: fulltext
issn:
  • 1079-5006
  • 10795006
url: Link


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titleA 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity.(Research Article)(Report)(Author abstract)
creatorRavussin, Eric ; Redman, Leanne M. ; Rochon, James ; Das, Sai Krupa ; Fontana, Luigi ; Kraus, William E. ; Romashkan, Sergei ; Williamson, Donald A. ; Meydani, Simin N. ; Villareal, Dennis T. ; Smith, Steven R. ; Stein, Richard I. ; Scott, Tammy M. ; Stewart, Tiffany M. ; Saltzman, Edward ; Klein, Samuel ; Bhapkar, Manju ; Martin, Corby K. ; Gilhooly, Cheryl H. ; Holloszy, John O. ; Hadley, Evan C. ; Roberts, Susan B.
ispartofThe Journals of Gerontology, Series A, 2015, Vol.70(9), p.1097(8)
identifierISSN: 1079-5006
subjectLow Calorie Diet – Research ; Life Span (Biology) – Research
descriptionBackground. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR. Methods. To determine CR's feasibility, safety, and effects on predictors of longevity, disease risk factors, and quality of life in nonobese humans aged 21-51 years, 218 persons were randomized to a 2-year intervention designed to achieve 25% CR or to AL diet. Outcomes were change from baseline resting metabolic rate adjusted for weight change ("RMR residual") and core temperature (primary); plasma triiodothyronine (T3) and tumor necrosis factor-[alpha] (secondary); and exploratory physiological and psychological measures. Results. Body mass index averaged 25.1 (range: 21.9-28.0kg/[m.sup.2]). Eighty-two percent of CR and 95% of AL participants completed the protocol. The CR group achieved 11.7[+ or -]0.7 %CR (mean [+ or -] standard error) and maintained 10.4[+ or -]0.4% weight loss. Weight change in AL was negligible. RMR residual decreased significantly more in CR than AL at 12 months (p = .04) but not 24 months (M24). Core temperature change differed little between groups. T3 decreased more in CR at M12 and M24 (p < .001), while tumor necrosis factor-a decreased significantly more only at M24 (p = .02). CR had larger decreases in cardiometabolic risk factors and in daily energy expenditure adjusted for weight change, without adverse effects on quality of life. Conclusions. Sustained CR is feasible in nonobese humans. The effects of the achieved CR on correlates of human survival and disease risk factors suggest potential benefits for aging-related outcomes that could be elucidated by further human studies. Key Words: Metabolism--Nutrition--Risk factors--Biomarkers--Caloric restriction doi:10.1093/gerona/glv057
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titleA 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity.(Research Article)(Report)(Author abstract)
descriptionBackground. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR. Methods. To determine CR's feasibility, safety, and effects on predictors of longevity, disease risk factors, and quality of life in nonobese humans aged 21-51 years, 218 persons were randomized to a 2-year intervention designed to achieve 25% CR or to AL diet. Outcomes were change from baseline resting metabolic rate adjusted for weight change ("RMR residual") and core temperature (primary); plasma triiodothyronine (T3) and tumor necrosis factor-[alpha] (secondary); and exploratory physiological and psychological measures. Results. Body mass index averaged 25.1 (range: 21.9-28.0kg/[m.sup.2]). Eighty-two percent of CR and 95% of AL participants completed the protocol. The CR group achieved 11.7[+ or -]0.7 %CR (mean [+ or -] standard error) and maintained 10.4[+ or -]0.4% weight loss. Weight change in AL was negligible. RMR residual decreased significantly more in CR than AL at 12 months (p = .04) but not 24 months (M24). Core temperature change differed little between groups. T3 decreased more in CR at M12 and M24 (p < .001), while tumor necrosis factor-a decreased significantly more only at M24 (p = .02). CR had larger decreases in cardiometabolic risk factors and in daily energy expenditure adjusted for weight change, without adverse effects on quality of life. Conclusions. Sustained CR is feasible in nonobese humans. The effects of the achieved CR on correlates of human survival and disease risk factors suggest potential benefits for aging-related outcomes that could be elucidated by further human studies. Key Words: Metabolism--Nutrition--Risk factors--Biomarkers--Caloric restriction doi:10.1093/gerona/glv057
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atitleA 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity.
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abstractBackground. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR. Methods. To determine CR's feasibility, safety, and effects on predictors of longevity, disease risk factors, and quality of life in nonobese humans aged 21-51 years, 218 persons were randomized to a 2-year intervention designed to achieve 25% CR or to AL diet. Outcomes were change from baseline resting metabolic rate adjusted for weight change ("RMR residual") and core temperature (primary); plasma triiodothyronine (T3) and tumor necrosis factor-[alpha] (secondary); and exploratory physiological and psychological measures. Results. Body mass index averaged 25.1 (range: 21.9-28.0kg/[m.sup.2]). Eighty-two percent of CR and 95% of AL participants completed the protocol. The CR group achieved 11.7[+ or -]0.7 %CR (mean [+ or -] standard error) and maintained 10.4[+ or -]0.4% weight loss. Weight change in AL was negligible. RMR residual decreased significantly more in CR than AL at 12 months (p = .04) but not 24 months (M24). Core temperature change differed little between groups. T3 decreased more in CR at M12 and M24 (p < .001), while tumor necrosis factor-a decreased significantly more only at M24 (p = .02). CR had larger decreases in cardiometabolic risk factors and in daily energy expenditure adjusted for weight change, without adverse effects on quality of life. Conclusions. Sustained CR is feasible in nonobese humans. The effects of the achieved CR on correlates of human survival and disease risk factors suggest potential benefits for aging-related outcomes that could be elucidated by further human studies. Key Words: Metabolism--Nutrition--Risk factors--Biomarkers--Caloric restriction doi:10.1093/gerona/glv057
pubGerontological Society of America
lad01gale_ofa
pages1097-1104
doi10.1093/gerona/glv057
eissn1758535X
date2015-09-01