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Targeting doxorubicin encapsulated in stealth liposomes to solid tumors by non thermal diode laser.(Report)

Background The use of liposomes as drug delivery systems is the most promising technique for targeting drug especially for anticancer therapy. Methods In this study sterically stabilized liposomes was prepared from DPPC/Cholesterol/PEG-PE encapsulated doxorubicin. The effect of lyophilization on lip... Full description

Journal Title: Lipids in Health and Disease April 5, 2016, Vol.15(68)
Main Author: Ghannam, Magdy M.
Other Authors: El Gebaly, Reem , Fadel, Maha
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1476-511X ; DOI: 10.1186/s12944-016-0235-2
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recordid: gale_ofa448459170
title: Targeting doxorubicin encapsulated in stealth liposomes to solid tumors by non thermal diode laser.(Report)
format: Article
creator:
  • Ghannam, Magdy M.
  • El Gebaly, Reem
  • Fadel, Maha
subjects:
  • Tumors – Research
  • Tumors – Care and Treatment
  • Tumors – Complications and Side Effects
  • Drug Delivery Systems – Analysis
  • Lasers – Usage
  • Lasers – Health Aspects
  • Doxorubicin – Research
  • Doxorubicin – Health Aspects
ispartof: Lipids in Health and Disease, April 5, 2016, Vol.15(68)
description: Background The use of liposomes as drug delivery systems is the most promising technique for targeting drug especially for anticancer therapy. Methods In this study sterically stabilized liposomes was prepared from DPPC/Cholesterol/PEG-PE encapsulated doxorubicin. The effect of lyophilization on liposomal stability and hence expiration date were studied. Moreover, the effect of diode laser on the drug released from liposomesin vitro and in vivo in mice carrying implanted solid tumor were also studied. Results The results indicated that lyophilization of the prepared liposomes encapsulating doxorubicin led to marked stability when stored at 5 #194;#176;C and it is possible to use the re-hydrated lyophilized liposomes within 12 days post reconstitution. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells is a promising method in cancer therapy. Conclusion We can conclude that lyophilization of the liposomes encapsulating doxorubicin lead to marked stability for the liposomes when stored at 5#194;#176;C. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells through the use of photosensitive sterically stabilized liposomes loaded with doxorubicin is a promising method. It proved to be applicable and successful for treatment of Ehrlich solid tumors implanted in mice and eliminated toxic side effects of doxorubicin. Keywords: Liposomes, Doxorubicin, Diode laser, Anticancer
language: eng
source:
identifier: ISSN: 1476-511X ; DOI: 10.1186/s12944-016-0235-2
fulltext: fulltext
issn:
  • 1476-511X
  • 1476511X
url: Link


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titleTargeting doxorubicin encapsulated in stealth liposomes to solid tumors by non thermal diode laser.(Report)
creatorGhannam, Magdy M. ; El Gebaly, Reem ; Fadel, Maha
ispartofLipids in Health and Disease, April 5, 2016, Vol.15(68)
identifierISSN: 1476-511X ; DOI: 10.1186/s12944-016-0235-2
subjectTumors – Research ; Tumors – Care and Treatment ; Tumors – Complications and Side Effects ; Drug Delivery Systems – Analysis ; Lasers – Usage ; Lasers – Health Aspects ; Doxorubicin – Research ; Doxorubicin – Health Aspects
descriptionBackground The use of liposomes as drug delivery systems is the most promising technique for targeting drug especially for anticancer therapy. Methods In this study sterically stabilized liposomes was prepared from DPPC/Cholesterol/PEG-PE encapsulated doxorubicin. The effect of lyophilization on liposomal stability and hence expiration date were studied. Moreover, the effect of diode laser on the drug released from liposomesin vitro and in vivo in mice carrying implanted solid tumor were also studied. Results The results indicated that lyophilization of the prepared liposomes encapsulating doxorubicin led to marked stability when stored at 5 #194;#176;C and it is possible to use the re-hydrated lyophilized liposomes within 12 days post reconstitution. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells is a promising method in cancer therapy. Conclusion We can conclude that lyophilization of the liposomes encapsulating doxorubicin lead to marked stability for the liposomes when stored at 5#194;#176;C. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells through the use of photosensitive sterically stabilized liposomes loaded with doxorubicin is a promising method. It proved to be applicable and successful for treatment of Ehrlich solid tumors implanted in mice and eliminated toxic side effects of doxorubicin. Keywords: Liposomes, Doxorubicin, Diode laser, Anticancer
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descriptionBackground The use of liposomes as drug delivery systems is the most promising technique for targeting drug especially for anticancer therapy. Methods In this study sterically stabilized liposomes was prepared from DPPC/Cholesterol/PEG-PE encapsulated doxorubicin. The effect of lyophilization on liposomal stability and hence expiration date were studied. Moreover, the effect of diode laser on the drug released from liposomesin vitro and in vivo in mice carrying implanted solid tumor were also studied. Results The results indicated that lyophilization of the prepared liposomes encapsulating doxorubicin led to marked stability when stored at 5 #194;#176;C and it is possible to use the re-hydrated lyophilized liposomes within 12 days post reconstitution. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells is a promising method in cancer therapy. Conclusion We can conclude that lyophilization of the liposomes encapsulating doxorubicin lead to marked stability for the liposomes when stored at 5#194;#176;C. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells through the use of photosensitive sterically stabilized liposomes loaded with doxorubicin is a promising method. It proved to be applicable and successful for treatment of Ehrlich solid tumors implanted in mice and eliminated toxic side effects of doxorubicin. Keywords: Liposomes, Doxorubicin, Diode laser, Anticancer
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abstractBackground The use of liposomes as drug delivery systems is the most promising technique for targeting drug especially for anticancer therapy. Methods In this study sterically stabilized liposomes was prepared from DPPC/Cholesterol/PEG-PE encapsulated doxorubicin. The effect of lyophilization on liposomal stability and hence expiration date were studied. Moreover, the effect of diode laser on the drug released from liposomesin vitro and in vivo in mice carrying implanted solid tumor were also studied. Results The results indicated that lyophilization of the prepared liposomes encapsulating doxorubicin led to marked stability when stored at 5 #194;#176;C and it is possible to use the re-hydrated lyophilized liposomes within 12 days post reconstitution. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells is a promising method in cancer therapy. Conclusion We can conclude that lyophilization of the liposomes encapsulating doxorubicin lead to marked stability for the liposomes when stored at 5#194;#176;C. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells through the use of photosensitive sterically stabilized liposomes loaded with doxorubicin is a promising method. It proved to be applicable and successful for treatment of Ehrlich solid tumors implanted in mice and eliminated toxic side effects of doxorubicin. Keywords: Liposomes, Doxorubicin, Diode laser, Anticancer
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