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Ageing: Dietary protection for genes

The accumulation of DNA damage is an inevitable side effect of living, and is one of the main causes of cellular and organismal ageing. Compromised DNA repair leads to persistent DNA damage, causing age-related disorders and shortening lifespans. In humans, this can manifest as progeroid syndromes,... Full description

Journal Title: Nature Sept 15, 2016, Vol.537(7620), p.316(2)
Main Author: Oshima, Junko
Other Authors: Martin, George M.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0028-0836 ; DOI: 10.1038/nature19427
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recordid: gale_ofa463523268
title: Ageing: Dietary protection for genes
format: Article
creator:
  • Oshima, Junko
  • Martin, George M.
subjects:
  • DNA Damage – Prevention
  • Cell Aging – Prevention
  • Longevity – Methods
  • Rapamycin – Physiological Aspects
  • Low Calorie Diet – Genetic Aspects
ispartof: Nature, Sept 15, 2016, Vol.537(7620), p.316(2)
description: The accumulation of DNA damage is an inevitable side effect of living, and is one of the main causes of cellular and organismal ageing. Compromised DNA repair leads to persistent DNA damage, causing age-related disorders and shortening lifespans. In humans, this can manifest as progeroid syndromes, in which children or adults age at a greatly accelerated rate. On page 427, Vermeij et al.1 demonstrate that a relatively modest degree of dietary restriction can greatly increase the lifespans of two mouse models of these human syndromes.
language: eng
source:
identifier: ISSN: 0028-0836 ; DOI: 10.1038/nature19427
fulltext: fulltext
issn:
  • 0028-0836
  • 00280836
url: Link


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descriptionThe accumulation of DNA damage is an inevitable side effect of living, and is one of the main causes of cellular and organismal ageing. Compromised DNA repair leads to persistent DNA damage, causing age-related disorders and shortening lifespans. In humans, this can manifest as progeroid syndromes, in which children or adults age at a greatly accelerated rate. On page 427, Vermeij et al.1 demonstrate that a relatively modest degree of dietary restriction can greatly increase the lifespans of two mouse models of these human syndromes.
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