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Metabolomics: beyond biomarkers and towards mechanisms.(Report)

Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to exp... Full description

Journal Title: Nature Reviews Molecular Cell Biology 2016, Vol.17(7), p.451(9)
Main Author: Johnson, Caroline H.
Other Authors: Ivanisevic, Julijana , Siuzdak, Gary
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1471-0072 ; DOI: 10.1038/nrm.2016.25
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recordid: gale_ofa502962063
title: Metabolomics: beyond biomarkers and towards mechanisms.(Report)
format: Article
creator:
  • Johnson, Caroline H.
  • Ivanisevic, Julijana
  • Siuzdak, Gary
subjects:
  • Metabolomics – Forecasts and Trends
  • Cancer Cells – Physiological Aspects
  • Cancer Cells – Health Aspects
  • Biological Markers – Identification and Classification
  • Biological Markers – Health Aspects
ispartof: Nature Reviews Molecular Cell Biology, 2016, Vol.17(7), p.451(9)
description: Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to expand metabolomic analyses to understand the systems-level effects of metabolites. Moreover, because of the inherent sensitivity of metabolomics, subtle alterations in biological pathways can be detected to provide insight into the mechanisms that underlie various physiological conditions and aberrant processes, including diseases.
language: eng
source:
identifier: ISSN: 1471-0072 ; DOI: 10.1038/nrm.2016.25
fulltext: fulltext
issn:
  • 1471-0072
  • 14710072
url: Link


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titleMetabolomics: beyond biomarkers and towards mechanisms.(Report)
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identifierISSN: 1471-0072 ; DOI: 10.1038/nrm.2016.25
subjectMetabolomics – Forecasts and Trends ; Cancer Cells – Physiological Aspects ; Cancer Cells – Health Aspects ; Biological Markers – Identification and Classification ; Biological Markers – Health Aspects
descriptionMetabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to expand metabolomic analyses to understand the systems-level effects of metabolites. Moreover, because of the inherent sensitivity of metabolomics, subtle alterations in biological pathways can be detected to provide insight into the mechanisms that underlie various physiological conditions and aberrant processes, including diseases.
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titleMetabolomics: beyond biomarkers and towards mechanisms.(Report)
descriptionMetabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to expand metabolomic analyses to understand the systems-level effects of metabolites. Moreover, because of the inherent sensitivity of metabolomics, subtle alterations in biological pathways can be detected to provide insight into the mechanisms that underlie various physiological conditions and aberrant processes, including diseases.
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abstractMetabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to expand metabolomic analyses to understand the systems-level effects of metabolites. Moreover, because of the inherent sensitivity of metabolomics, subtle alterations in biological pathways can be detected to provide insight into the mechanisms that underlie various physiological conditions and aberrant processes, including diseases.
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