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Effects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial.(Research Article)(Report)(Author abstract)

Background: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life. Methods: We conducte... Full description

Journal Title: The Journals of Gerontology Series A, 2018, Vol.73(1), p.73(8)
Main Author: Ard, Jamy D.
Other Authors: Gower, Barbara , Hunter, Gary , Ritchie, Christine S. , Roth, David L. , Goss, Amy , Wingo, Brooks C. , Bodner, Eric V. , Brown, Cynthia J. , Bryan, David , Buys, David R. , Haas, Marilyn C. , Keita, Akilah Dulin , Flagg, Lee Anne , Williams, Courtney P. , Locher, Julie L.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1079-5006 ; DOI: 10.1093/gerona/glw237
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recordid: gale_ofa523062258
title: Effects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial.(Research Article)(Report)(Author abstract)
format: Article
creator:
  • Ard, Jamy D.
  • Gower, Barbara
  • Hunter, Gary
  • Ritchie, Christine S.
  • Roth, David L.
  • Goss, Amy
  • Wingo, Brooks C.
  • Bodner, Eric V.
  • Brown, Cynthia J.
  • Bryan, David
  • Buys, David R.
  • Haas, Marilyn C.
  • Keita, Akilah Dulin
  • Flagg, Lee Anne
  • Williams, Courtney P.
  • Locher, Julie L.
subjects:
  • Low Calorie Diet – Patient Outcomes
  • Cardiovascular Diseases – Prevention
  • Cardiovascular Diseases – Risk Factors
  • Obesity – Development and Progression
ispartof: The Journals of Gerontology, Series A, 2018, Vol.73(1), p.73(8)
description: Background: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life. Methods: We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss). The primary outcome was change in VAT at 12 months. Secondary outcomes included cardiometabolic risk factors, functional status, and quality of life. Results: A total of 148 participants had measured weight at 12 months. Despite loss of -1.6% [+ or -] 0.3% body fat and 4.1% [+ or -] 0.7% initial body weight, Weight Loss did not have statistically greater loss of VAT (-192.6 [+ or -] 185.2 [cm.sup.3]) or lean mass (-0.4 [+ or -] 0.3 kg) compared with Exercise (VAT = -21.9 [+ or -] 173.7 [cm.sup.3]; lean mass = 0.3 [+ or -] 0.3 kg). Quality of life improved in all groups with no differences between groups. No significant changes in physical function were observed. Weight Loss had significantly greater improvements in blood glucose (-8.3 [+ or -] 3.6 mg/dL, p < .05) and HDL-cholesterol (5.3 [+ or -] 1.9, p < .01) compared with Exercise. There were no group differences in the frequency of adverse events. Conclusions: While moderate calorie restriction did not significantly decrease VAT in older adults at high risk for cardiometabolic disease, it did reduce total body fat and cardiometabolic risk factors without significantly more adverse events and lean mass loss. Keywords: Weight reduction--cardiometabolic risk--visceral adipose tissue--quality of life--physical function doi:10.1093/gerona/glw237
language: eng
source:
identifier: ISSN: 1079-5006 ; DOI: 10.1093/gerona/glw237
fulltext: no_fulltext
issn:
  • 1079-5006
  • 10795006
url: Link


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titleEffects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial.(Research Article)(Report)(Author abstract)
creatorArd, Jamy D. ; Gower, Barbara ; Hunter, Gary ; Ritchie, Christine S. ; Roth, David L. ; Goss, Amy ; Wingo, Brooks C. ; Bodner, Eric V. ; Brown, Cynthia J. ; Bryan, David ; Buys, David R. ; Haas, Marilyn C. ; Keita, Akilah Dulin ; Flagg, Lee Anne ; Williams, Courtney P. ; Locher, Julie L.
ispartofThe Journals of Gerontology, Series A, 2018, Vol.73(1), p.73(8)
identifierISSN: 1079-5006 ; DOI: 10.1093/gerona/glw237
subjectLow Calorie Diet – Patient Outcomes ; Cardiovascular Diseases – Prevention ; Cardiovascular Diseases – Risk Factors ; Obesity – Development and Progression
descriptionBackground: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life. Methods: We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss). The primary outcome was change in VAT at 12 months. Secondary outcomes included cardiometabolic risk factors, functional status, and quality of life. Results: A total of 148 participants had measured weight at 12 months. Despite loss of -1.6% [+ or -] 0.3% body fat and 4.1% [+ or -] 0.7% initial body weight, Weight Loss did not have statistically greater loss of VAT (-192.6 [+ or -] 185.2 [cm.sup.3]) or lean mass (-0.4 [+ or -] 0.3 kg) compared with Exercise (VAT = -21.9 [+ or -] 173.7 [cm.sup.3]; lean mass = 0.3 [+ or -] 0.3 kg). Quality of life improved in all groups with no differences between groups. No significant changes in physical function were observed. Weight Loss had significantly greater improvements in blood glucose (-8.3 [+ or -] 3.6 mg/dL, p < .05) and HDL-cholesterol (5.3 [+ or -] 1.9, p < .01) compared with Exercise. There were no group differences in the frequency of adverse events. Conclusions: While moderate calorie restriction did not significantly decrease VAT in older adults at high risk for cardiometabolic disease, it did reduce total body fat and cardiometabolic risk factors without significantly more adverse events and lean mass loss. Keywords: Weight reduction--cardiometabolic risk--visceral adipose tissue--quality of life--physical function doi:10.1093/gerona/glw237
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titleEffects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial.(Research Article)(Report)(Author abstract)
descriptionBackground: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life. Methods: We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss). The primary outcome was change in VAT at 12 months. Secondary outcomes included cardiometabolic risk factors, functional status, and quality of life. Results: A total of 148 participants had measured weight at 12 months. Despite loss of -1.6% [+ or -] 0.3% body fat and 4.1% [+ or -] 0.7% initial body weight, Weight Loss did not have statistically greater loss of VAT (-192.6 [+ or -] 185.2 [cm.sup.3]) or lean mass (-0.4 [+ or -] 0.3 kg) compared with Exercise (VAT = -21.9 [+ or -] 173.7 [cm.sup.3]; lean mass = 0.3 [+ or -] 0.3 kg). Quality of life improved in all groups with no differences between groups. No significant changes in physical function were observed. Weight Loss had significantly greater improvements in blood glucose (-8.3 [+ or -] 3.6 mg/dL, p < .05) and HDL-cholesterol (5.3 [+ or -] 1.9, p < .01) compared with Exercise. There were no group differences in the frequency of adverse events. Conclusions: While moderate calorie restriction did not significantly decrease VAT in older adults at high risk for cardiometabolic disease, it did reduce total body fat and cardiometabolic risk factors without significantly more adverse events and lean mass loss. Keywords: Weight reduction--cardiometabolic risk--visceral adipose tissue--quality of life--physical function doi:10.1093/gerona/glw237
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titleEffects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial.(Research Article)(Report)(Author abstract)
authorArd, Jamy D. ; Gower, Barbara ; Hunter, Gary ; Ritchie, Christine S. ; Roth, David L. ; Goss, Amy ; Wingo, Brooks C. ; Bodner, Eric V. ; Brown, Cynthia J. ; Bryan, David ; Buys, David R. ; Haas, Marilyn C. ; Keita, Akilah Dulin ; Flagg, Lee Anne ; Williams, Courtney P. ; Locher, Julie L.
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abstractBackground: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life. Methods: We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss). The primary outcome was change in VAT at 12 months. Secondary outcomes included cardiometabolic risk factors, functional status, and quality of life. Results: A total of 148 participants had measured weight at 12 months. Despite loss of -1.6% [+ or -] 0.3% body fat and 4.1% [+ or -] 0.7% initial body weight, Weight Loss did not have statistically greater loss of VAT (-192.6 [+ or -] 185.2 [cm.sup.3]) or lean mass (-0.4 [+ or -] 0.3 kg) compared with Exercise (VAT = -21.9 [+ or -] 173.7 [cm.sup.3]; lean mass = 0.3 [+ or -] 0.3 kg). Quality of life improved in all groups with no differences between groups. No significant changes in physical function were observed. Weight Loss had significantly greater improvements in blood glucose (-8.3 [+ or -] 3.6 mg/dL, p < .05) and HDL-cholesterol (5.3 [+ or -] 1.9, p < .01) compared with Exercise. There were no group differences in the frequency of adverse events. Conclusions: While moderate calorie restriction did not significantly decrease VAT in older adults at high risk for cardiometabolic disease, it did reduce total body fat and cardiometabolic risk factors without significantly more adverse events and lean mass loss. Keywords: Weight reduction--cardiometabolic risk--visceral adipose tissue--quality of life--physical function doi:10.1093/gerona/glw237
pubGerontological Society of America
doi10.1093/gerona/glw237
lad01gale_ofa
pages73-80
eissn1758535X
date2018-01-01