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Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.(Report)

Byline: Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro,J. Alfredo Martinez,, I Abete, AB Crujeiras, M Cuervo, L Goni, A Marti, MA Martinez-Gonzalez, MJ Moreno-Aliaga, S Navas-Carretero, R San-Cristobal, JL Santos, MA Zulet Keywords: diet; dopamine; epigenetics; obesity; SLC18A1 ; SLC6A3 Abst... Full description

Journal Title: Brain and Behavior 2018, Vol.8(8), p.n/a(12)
Main Author: Ramos-Lopez, Omar
Other Authors: Riezu-Boj, Jose I. , Milagro, Fermin I. , Martinez, J. Alfredo , Abete, I , Crujeiras, AB , Cuervo, M , Goni, L , Marti, A , Martinez-Gonzalez, MA , Moreno-Aliaga, Mj , Navas-Carretero, S , San-Cristobal, R , Santos, Jl , Zulet, MA
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 2162-3279 ; DOI: 10.1002/brb3.1017
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title: Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.(Report)
format: Article
creator:
  • Ramos-Lopez, Omar
  • Riezu-Boj, Jose I.
  • Milagro, Fermin I.
  • Martinez, J. Alfredo
  • Abete, I
  • Crujeiras, AB
  • Cuervo, M
  • Goni, L
  • Marti, A
  • Martinez-Gonzalez, MA
  • Moreno-Aliaga, Mj
  • Navas-Carretero, S
  • San-Cristobal, R
  • Santos, Jl
  • Zulet, MA
subjects:
  • Obesity – Genetic Aspects
ispartof: Brain and Behavior, 2018, Vol.8(8), p.n/a(12)
description: Byline: Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro,J. Alfredo Martinez,, I Abete, AB Crujeiras, M Cuervo, L Goni, A Marti, MA Martinez-Gonzalez, MJ Moreno-Aliaga, S Navas-Carretero, R San-Cristobal, JL Santos, MA Zulet Keywords: diet; dopamine; epigenetics; obesity; SLC18A1 ; SLC6A3 Abstract Introduction Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake. Methods An adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened. Results After applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p 0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (CACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the presence or absence of abdominal obesity. Pathway analyses revealed a statistically significant contribution of the aforementioned genes to dopaminergic synapse transmission (p = 4.78E-08). Furthermore, SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p 0.001) and carbohydrate (p 0.001) intakes. Conclusions The results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition. Article Note: Funding information This investigation was supported by the grants from the Government of Navarra (PT024), CIBERobn (CB12/03/30002), MINECO (AGL2013-45554-R), and NUTRIGENIO (AGL2013-45554-R). O.R.L. was supported by a 2-year postdoctoral grant from National Council of Science and Technology, Mexi
language: eng
source:
identifier: ISSN: 2162-3279 ; DOI: 10.1002/brb3.1017
fulltext: fulltext
issn:
  • 2162-3279
  • 21623279
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titleDopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.(Report)
creatorRamos-Lopez, Omar ; Riezu-Boj, Jose I. ; Milagro, Fermin I. ; Martinez, J. Alfredo ; Abete, I ; Crujeiras, AB ; Cuervo, M ; Goni, L ; Marti, A ; Martinez-Gonzalez, MA ; Moreno-Aliaga, Mj ; Navas-Carretero, S ; San-Cristobal, R ; Santos, Jl ; Zulet, MA
ispartofBrain and Behavior, 2018, Vol.8(8), p.n/a(12)
identifierISSN: 2162-3279 ; DOI: 10.1002/brb3.1017
subjectObesity – Genetic Aspects
descriptionByline: Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro,J. Alfredo Martinez,, I Abete, AB Crujeiras, M Cuervo, L Goni, A Marti, MA Martinez-Gonzalez, MJ Moreno-Aliaga, S Navas-Carretero, R San-Cristobal, JL Santos, MA Zulet Keywords: diet; dopamine; epigenetics; obesity; SLC18A1 ; SLC6A3 Abstract Introduction Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake. Methods An adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened. Results After applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p 0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (CACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the presence or absence of abdominal obesity. Pathway analyses revealed a statistically significant contribution of the aforementioned genes to dopaminergic synapse transmission (p = 4.78E-08). Furthermore, SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p 0.001) and carbohydrate (p 0.001) intakes. Conclusions The results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition. Article Note: Funding information This investigation was supported by the grants from the Government of Navarra (PT024), CIBERobn (CB12/03/30002), MINECO (AGL2013-45554-R), and NUTRIGENIO (AGL2013-45554-R). O.R.L. was supported by a 2-year postdoctoral grant from National Council of Science and Technology, Mexico (CONACyT, Num. CVU. 444175) in collaboration with the PhD Program in Molecular Biology in Medicine, University of Guadalajara, Mexico (CONACyT, PNPC 000091) and the University of Navarra, Spain (LE/97). See Appendix.
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titleDopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.(Report)
descriptionByline: Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro,J. Alfredo Martinez,, I Abete, AB Crujeiras, M Cuervo, L Goni, A Marti, MA Martinez-Gonzalez, MJ Moreno-Aliaga, S Navas-Carretero, R San-Cristobal, JL Santos, MA Zulet Keywords: diet; dopamine; epigenetics; obesity; SLC18A1 ; SLC6A3 Abstract Introduction Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake. Methods An adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened. Results After applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p 0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (CACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the presence or absence of abdominal obesity. Pathway analyses revealed a statistically significant contribution of the aforementioned genes to dopaminergic synapse transmission (p = 4.78E-08). Furthermore, SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p 0.001) and carbohydrate (p 0.001) intakes. Conclusions The results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition. Article Note: Funding information This investigation was supported by the grants from the Government of Navarra (PT024), CIBERobn (CB12/03/30002), MINECO (AGL2013-45554-R), and NUTRIGENIO (AGL2013-45554-R). O.R.L. was supported by a 2-year postdoctoral grant from National Council of Science and Technology, Mexico (CONACyT, Num. CVU. 444175) in collaboration with the PhD Program in Molecular Biology in Medicine, University of Guadalajara, Mexico (CONACyT, PNPC 000091) and the University of Navarra, Spain (LE/97). See Appendix.
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titleDopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.(Report)
authorRamos-Lopez, Omar ; Riezu-Boj, Jose I. ; Milagro, Fermin I. ; Martinez, J. Alfredo ; Abete, I ; Crujeiras, AB ; Cuervo, M ; Goni, L ; Marti, A ; Martinez-Gonzalez, MA ; Moreno-Aliaga, Mj ; Navas-Carretero, S ; San-Cristobal, R ; Santos, Jl ; Zulet, MA
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abstractByline: Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro,J. Alfredo Martinez,, I Abete, AB Crujeiras, M Cuervo, L Goni, A Marti, MA Martinez-Gonzalez, MJ Moreno-Aliaga, S Navas-Carretero, R San-Cristobal, JL Santos, MA Zulet Keywords: diet; dopamine; epigenetics; obesity; SLC18A1 ; SLC6A3 Abstract Introduction Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake. Methods An adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened. Results After applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p 0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (CACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the presence or absence of abdominal obesity. Pathway analyses revealed a statistically significant contribution of the aforementioned genes to dopaminergic synapse transmission (p = 4.78E-08). Furthermore, SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p 0.001) and carbohydrate (p 0.001) intakes. Conclusions The results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition. Article Note: Funding information This investigation was supported by the grants from the Government of Navarra (PT024), CIBERobn (CB12/03/30002), MINECO (AGL2013-45554-R), and NUTRIGENIO (AGL2013-45554-R). O.R.L. was supported by a 2-year postdoctoral grant from National Council of Science and Technology, Mexico (CONACyT, Num. CVU. 444175) in collaboration with the PhD Program in Molecular Biology in Medicine, University of Guadalajara, Mexico (CONACyT, PNPC 000091) and the University of Navarra, Spain (LE/97). See Appendix.
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