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Structural basis for the modulation of voltage-gated sodium channels by animal toxins.(ION CHANNELS)

Structures of voltage-gated sodium channels In “excitable” cells, like neurons and muscle cells, a difference in electrical potential is used to transmit signals across the cell membrane. This difference is regulated by opening or closing ion channels in the cell membrane. For example, mutations in... Full description

Journal Title: Science Oct 19, 2018, Vol.362(6412), p.306(1)
Main Author: Shen, Huaizong
Other Authors: Li, Zhangqiang , Jiang, Yan , Pan, Xiaojing , Wuf, Jianping , Cristofori-Armstrong, Ben , Smith, Jennifer J. , Chin, Yanni K.Y. , Lei, Jianlin , Zhou, Qiang , King, Glenn F. , Yan, Nieng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0036-8075 ; DOI: 10.1126/science.aau2596
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recordid: gale_ofa562237819
title: Structural basis for the modulation of voltage-gated sodium channels by animal toxins.(ION CHANNELS)
format: Article
creator:
  • Shen, Huaizong
  • Li, Zhangqiang
  • Jiang, Yan
  • Pan, Xiaojing
  • Wuf, Jianping
  • Cristofori-Armstrong, Ben
  • Smith, Jennifer J.
  • Chin, Yanni K.Y.
  • Lei, Jianlin
  • Zhou, Qiang
  • King, Glenn F.
  • Yan, Nieng
subjects:
  • Marine Toxins
ispartof: Science, Oct 19, 2018, Vol.362(6412), p.306(1)
description: Structures of voltage-gated sodium channels In “excitable” cells, like neurons and muscle cells, a difference in electrical potential is used to transmit signals across the cell membrane. This difference is regulated by opening or closing ion channels in the cell membrane. For example, mutations in human voltage-gated sodium (Nav) channels are associated with disorders such as chronic pain, epilepsy, and cardiac arrhythmia. Pan et al. report the high-resolution structure of a human Nav channel, and Shen et al. report the structures of an insect Nav channel bound to the toxins that cause pufferfish and shellfish poisoning in humans. Together, the structures give insight into the molecular basis of sodium ion permeation and provide a path toward structure-based drug discovery. Science, this issue p. eaau2486, p. eaau2596INTRODUCTION Almost all venoms contain toxins that modulate the activity of voltage-gated sodium (Nav) channels in order to incapacitate prey or predators. The single-chain...
language: eng
source:
identifier: ISSN: 0036-8075 ; DOI: 10.1126/science.aau2596
fulltext: no_fulltext
issn:
  • 0036-8075
  • 00368075
url: Link


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titleStructural basis for the modulation of voltage-gated sodium channels by animal toxins.(ION CHANNELS)
creatorShen, Huaizong ; Li, Zhangqiang ; Jiang, Yan ; Pan, Xiaojing ; Wuf, Jianping ; Cristofori-Armstrong, Ben ; Smith, Jennifer J. ; Chin, Yanni K.Y. ; Lei, Jianlin ; Zhou, Qiang ; King, Glenn F. ; Yan, Nieng
ispartofScience, Oct 19, 2018, Vol.362(6412), p.306(1)
identifierISSN: 0036-8075 ; DOI: 10.1126/science.aau2596
subjectMarine Toxins
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descriptionStructures of voltage-gated sodium channels In “excitable” cells, like neurons and muscle cells, a difference in electrical potential is used to transmit signals across the cell membrane. This difference is regulated by opening or closing ion channels in the cell membrane. For example, mutations in human voltage-gated sodium (Nav) channels are associated with disorders such as chronic pain, epilepsy, and cardiac arrhythmia. Pan et al. report the high-resolution structure of a human Nav channel, and Shen et al. report the structures of an insect Nav channel bound to the toxins that cause pufferfish and shellfish poisoning in humans. Together, the structures give insight into the molecular basis of sodium ion permeation and provide a path toward structure-based drug discovery. Science, this issue p. eaau2486, p. eaau2596INTRODUCTION Almost all venoms contain toxins that modulate the activity of voltage-gated sodium (Nav) channels in order to incapacitate prey or predators. The single-chain...
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titleStructural basis for the modulation of voltage-gated sodium channels by animal toxins.(ION CHANNELS)
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