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Quorum Sensing Inhibition in Chromobacterium violaceum by Amikacin Combination with Activated Charcoal or Small Plant-Derived Molecules (Pyrogallol and Coumarin).(Report)

Byline: K. S. Inchagova (1), G. K. Duskaev (1), D. G. Deryabin (1) Keywords: quorum sensing; Chromobacterium violaceum; amikacin; activated charcoal; pyrogallol; coumarin Abstract: The study was aimed at effective inhibition of quorum sensing (QS) in the model bacterium Chromobacterium violaceum ATC... Full description

Journal Title: Microbiology Journal 2019, Vol.88(1), p.63(9)
Main Author: Inchagova, K. S.
Other Authors: Duskaev, G. K. , Deryabin, D. G.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0026-2617 ; DOI: 10.1134/S0026261719010132
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recordid: gale_ofa582875654
title: Quorum Sensing Inhibition in Chromobacterium violaceum by Amikacin Combination with Activated Charcoal or Small Plant-Derived Molecules (Pyrogallol and Coumarin).(Report)
format: Article
creator:
  • Inchagova, K. S.
  • Duskaev, G. K.
  • Deryabin, D. G.
subjects:
  • Bacterial Infections – Analysis
  • Amikacin – Usage
  • Amikacin – Analysis
ispartof: Microbiology Journal, 2019, Vol.88(1), p.63(9)
description: Byline: K. S. Inchagova (1), G. K. Duskaev (1), D. G. Deryabin (1) Keywords: quorum sensing; Chromobacterium violaceum; amikacin; activated charcoal; pyrogallol; coumarin Abstract: The study was aimed at effective inhibition of quorum sensing (QS) in the model bacterium Chromobacterium violaceum ATCC 31532 by combinations of compounds with different anti-QS activity mechanisms. These mechanisms were: (1) suppression of autoinducer (C.sub.6-AHL) biosynthesis by subinhibitory concentrations of an aminoglycoside antibiotic amikacin (2) sorption of synthesized C.sub.6-AHL on activated charcoal particles and (3) decreasing the bacterial cells sensitivity to the autoinducer by low-molecular weight compounds of plant origin: pyrogallol or coumarin. Simultaneous presence of amikacin and activated charcoal in the cultivation medium paradoxically decreased their combined anti-QS activity due to partial binding of the antibiotic to the sorbent particles, while two-step use of first the antibiotic and then the sorbent led to an additive effect due to sequential decrease the of C.sub.6-AHL extracellular concentration. Amikacin combinations with pyrogallol or coumarin resulted in a expressed anti-QS effect, with evidence of superadditivity showed by isobolographic analysis. Probable formation of the tested compositions in the natural environment is discussed, as well as their possible application against the bacterial infections, which use the QS system for induction of their pathogenic potential. Author Affiliation: (1) 0000 0001 2192 9124, grid.4886.2, Federal Research Center of Biological Systems and Agrotechnologies, Russian Academy of Sciences, 460000, Orenburg, Russia Article History: Registration Date: 03/04/2019 Received Date: 08/11/2018 Accepted Date: 10/12/2018 Online Date: 18/04/2019
language: eng
source:
identifier: ISSN: 0026-2617 ; DOI: 10.1134/S0026261719010132
fulltext: fulltext
issn:
  • 0026-2617
  • 00262617
url: Link


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titleQuorum Sensing Inhibition in Chromobacterium violaceum by Amikacin Combination with Activated Charcoal or Small Plant-Derived Molecules (Pyrogallol and Coumarin).(Report)
creatorInchagova, K. S. ; Duskaev, G. K. ; Deryabin, D. G.
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identifierISSN: 0026-2617 ; DOI: 10.1134/S0026261719010132
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descriptionByline: K. S. Inchagova (1), G. K. Duskaev (1), D. G. Deryabin (1) Keywords: quorum sensing; Chromobacterium violaceum; amikacin; activated charcoal; pyrogallol; coumarin Abstract: The study was aimed at effective inhibition of quorum sensing (QS) in the model bacterium Chromobacterium violaceum ATCC 31532 by combinations of compounds with different anti-QS activity mechanisms. These mechanisms were: (1) suppression of autoinducer (C.sub.6-AHL) biosynthesis by subinhibitory concentrations of an aminoglycoside antibiotic amikacin (2) sorption of synthesized C.sub.6-AHL on activated charcoal particles and (3) decreasing the bacterial cells sensitivity to the autoinducer by low-molecular weight compounds of plant origin: pyrogallol or coumarin. Simultaneous presence of amikacin and activated charcoal in the cultivation medium paradoxically decreased their combined anti-QS activity due to partial binding of the antibiotic to the sorbent particles, while two-step use of first the antibiotic and then the sorbent led to an additive effect due to sequential decrease the of C.sub.6-AHL extracellular concentration. Amikacin combinations with pyrogallol or coumarin resulted in a expressed anti-QS effect, with evidence of superadditivity showed by isobolographic analysis. Probable formation of the tested compositions in the natural environment is discussed, as well as their possible application against the bacterial infections, which use the QS system for induction of their pathogenic potential. Author Affiliation: (1) 0000 0001 2192 9124, grid.4886.2, Federal Research Center of Biological Systems and Agrotechnologies, Russian Academy of Sciences, 460000, Orenburg, Russia Article History: Registration Date: 03/04/2019 Received Date: 08/11/2018 Accepted Date: 10/12/2018 Online Date: 18/04/2019
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descriptionByline: K. S. Inchagova (1), G. K. Duskaev (1), D. G. Deryabin (1) Keywords: quorum sensing; Chromobacterium violaceum; amikacin; activated charcoal; pyrogallol; coumarin Abstract: The study was aimed at effective inhibition of quorum sensing (QS) in the model bacterium Chromobacterium violaceum ATCC 31532 by combinations of compounds with different anti-QS activity mechanisms. These mechanisms were: (1) suppression of autoinducer (C.sub.6-AHL) biosynthesis by subinhibitory concentrations of an aminoglycoside antibiotic amikacin (2) sorption of synthesized C.sub.6-AHL on activated charcoal particles and (3) decreasing the bacterial cells sensitivity to the autoinducer by low-molecular weight compounds of plant origin: pyrogallol or coumarin. Simultaneous presence of amikacin and activated charcoal in the cultivation medium paradoxically decreased their combined anti-QS activity due to partial binding of the antibiotic to the sorbent particles, while two-step use of first the antibiotic and then the sorbent led to an additive effect due to sequential decrease the of C.sub.6-AHL extracellular concentration. Amikacin combinations with pyrogallol or coumarin resulted in a expressed anti-QS effect, with evidence of superadditivity showed by isobolographic analysis. Probable formation of the tested compositions in the natural environment is discussed, as well as their possible application against the bacterial infections, which use the QS system for induction of their pathogenic potential. Author Affiliation: (1) 0000 0001 2192 9124, grid.4886.2, Federal Research Center of Biological Systems and Agrotechnologies, Russian Academy of Sciences, 460000, Orenburg, Russia Article History: Registration Date: 03/04/2019 Received Date: 08/11/2018 Accepted Date: 10/12/2018 Online Date: 18/04/2019
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abstractByline: K. S. Inchagova (1), G. K. Duskaev (1), D. G. Deryabin (1) Keywords: quorum sensing; Chromobacterium violaceum; amikacin; activated charcoal; pyrogallol; coumarin Abstract: The study was aimed at effective inhibition of quorum sensing (QS) in the model bacterium Chromobacterium violaceum ATCC 31532 by combinations of compounds with different anti-QS activity mechanisms. These mechanisms were: (1) suppression of autoinducer (C.sub.6-AHL) biosynthesis by subinhibitory concentrations of an aminoglycoside antibiotic amikacin (2) sorption of synthesized C.sub.6-AHL on activated charcoal particles and (3) decreasing the bacterial cells sensitivity to the autoinducer by low-molecular weight compounds of plant origin: pyrogallol or coumarin. Simultaneous presence of amikacin and activated charcoal in the cultivation medium paradoxically decreased their combined anti-QS activity due to partial binding of the antibiotic to the sorbent particles, while two-step use of first the antibiotic and then the sorbent led to an additive effect due to sequential decrease the of C.sub.6-AHL extracellular concentration. Amikacin combinations with pyrogallol or coumarin resulted in a expressed anti-QS effect, with evidence of superadditivity showed by isobolographic analysis. Probable formation of the tested compositions in the natural environment is discussed, as well as their possible application against the bacterial infections, which use the QS system for induction of their pathogenic potential. Author Affiliation: (1) 0000 0001 2192 9124, grid.4886.2, Federal Research Center of Biological Systems and Agrotechnologies, Russian Academy of Sciences, 460000, Orenburg, Russia Article History: Registration Date: 03/04/2019 Received Date: 08/11/2018 Accepted Date: 10/12/2018 Online Date: 18/04/2019
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