schliessen

Filtern

 

Bibliotheken

Twenty-four-hour oral tracer studies with L-[1-[sup.13]C]lysine at a low (15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) and intermediate (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) lysine intake in healthy adults

Background: We proposed previously that the mean lysine requirement value is [approximately equals] 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] rather than the proposed 1985 FAO/WHO/UNU estimate of the upper range of the requirement, which is 12 mg [multiplied by] [kg.sup.-1] [multi... Full description

Journal Title: American Journal of Clinical Nutrition July, 2000, Vol.72(1), p.122
Main Author: El - Khoury, Antoine E
Other Authors: Pereira, Paulo Cm , Borgonha, Sudhir , Basile - Filho, Anibal , Beaumier, Louis , Wang, San Y , Metges, Cornelia C , Ajami, Alfred M , Young, Vernon R
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0002-9165
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: gale_ofa63771877
title: Twenty-four-hour oral tracer studies with L-[1-[sup.13]C]lysine at a low (15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) and intermediate (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) lysine intake in healthy adults
format: Article
creator:
  • El - Khoury, Antoine E
  • Pereira, Paulo Cm
  • Borgonha, Sudhir
  • Basile - Filho, Anibal
  • Beaumier, Louis
  • Wang, San Y
  • Metges, Cornelia C
  • Ajami, Alfred M
  • Young, Vernon R
subjects:
  • Lysine -- Physiological Aspects
  • Oxidative Stress -- Measurement
  • Nutritional Requirements
ispartof: American Journal of Clinical Nutrition, July, 2000, Vol.72(1), p.122
description: Background: We proposed previously that the mean lysine requirement value is [approximately equals] 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] rather than the proposed 1985 FAO/WHO/UNU estimate of the upper range of the requirement, which is 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Objective: Our objective was to explore the 24-h pattern and rate of whole-body lysine [1-[sup.13]C]oxidation and status of whole-body lysine balance in healthy, young adults given an L-amino acid diet supplying either a low lysine intake (14-15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) or an intermediate lysine intake (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) for 6 d before a continuous tracer study with L-[1-[sup.13]C]lysine. Design: Five subjects received the low lysine intake, 6 subjects received the intermediate intake, and all were studied by using a standard 24-h oral tracer protocol that was described earlier for studies at a generous lysine intake. Results: The rate of lysine oxidation was not significantly different between the 12-h fasted and 12-h fed states. The daily oxidation rate ([Bar]x [+ or -] SD) was 27.9 [+ or -] 8.8 and 27.3 [+ or -] 17.6 mg lysine [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] for the low- and intermediate-intake groups, respectively (NS). Daily lysine balance was -12.4 [+ or -] 92 and 1.8 [+ or -] 17.7 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1], respectively (P [is less than] 0.025), for the low and intermediate intakes. The balance was significantly less than zero (P [is less than] 0.001) for the low intake. Conclusion: The FAO/WHO/UNU lysine requirement value is not sufficient to maintain lysine homeostasis in healthy adults. From the results of this and tracer studies done by others, the mean lysine requirement of healthy adults was determined to be 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Am J Clin Nutr 2000;72:122-30. KEY WORDS Lysine, oral tracer studies, amino acids, oxidation, healthy adults
language:
source:
identifier: ISSN: 0002-9165
fulltext: fulltext
issn:
  • 0002-9165
  • 00029165
url: Link


@attributes
ID1424799918
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid63771877
sourceidgale_ofa
recordidTN_gale_ofa63771877
sourceformatXML
sourcesystemPC
pqid71224630
galeid63771877
display
typearticle
titleTwenty-four-hour oral tracer studies with L-[1-[sup.13]C]lysine at a low (15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) and intermediate (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) lysine intake in healthy adults
creatorEl - Khoury, Antoine E ; Pereira, Paulo Cm ; Borgonha, Sudhir ; Basile - Filho, Anibal ; Beaumier, Louis ; Wang, San Y ; Metges, Cornelia C ; Ajami, Alfred M ; Young, Vernon R
ispartofAmerican Journal of Clinical Nutrition, July, 2000, Vol.72(1), p.122
identifierISSN: 0002-9165
subjectLysine -- Physiological Aspects ; Oxidative Stress -- Measurement ; Nutritional Requirements
descriptionBackground: We proposed previously that the mean lysine requirement value is [approximately equals] 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] rather than the proposed 1985 FAO/WHO/UNU estimate of the upper range of the requirement, which is 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Objective: Our objective was to explore the 24-h pattern and rate of whole-body lysine [1-[sup.13]C]oxidation and status of whole-body lysine balance in healthy, young adults given an L-amino acid diet supplying either a low lysine intake (14-15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) or an intermediate lysine intake (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) for 6 d before a continuous tracer study with L-[1-[sup.13]C]lysine. Design: Five subjects received the low lysine intake, 6 subjects received the intermediate intake, and all were studied by using a standard 24-h oral tracer protocol that was described earlier for studies at a generous lysine intake. Results: The rate of lysine oxidation was not significantly different between the 12-h fasted and 12-h fed states. The daily oxidation rate ([Bar]x [+ or -] SD) was 27.9 [+ or -] 8.8 and 27.3 [+ or -] 17.6 mg lysine [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] for the low- and intermediate-intake groups, respectively (NS). Daily lysine balance was -12.4 [+ or -] 92 and 1.8 [+ or -] 17.7 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1], respectively (P [is less than] 0.025), for the low and intermediate intakes. The balance was significantly less than zero (P [is less than] 0.001) for the low intake. Conclusion: The FAO/WHO/UNU lysine requirement value is not sufficient to maintain lysine homeostasis in healthy adults. From the results of this and tracer studies done by others, the mean lysine requirement of healthy adults was determined to be 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Am J Clin Nutr 2000;72:122-30. KEY WORDS Lysine, oral tracer studies, amino acids, oxidation, healthy adults
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
scope
0gale_onefileg
1gale_onefilea
2OneFile
creatorcontrib
0El-Khoury, Antoine E
1Pereira, Paulo CM
2Borgonha, Sudhir
3Basile-Filho, Anibal
4Beaumier, Louis
5Wang, San Y
6Metges, Cornelia C
7Ajami, Alfred M
8Young, Vernon R
titleTwenty-four-hour oral tracer studies with L-[1-[sup.13]C]lysine at a low (15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) and intermediate (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) lysine intake in healthy adults.
descriptionBackground: We proposed previously that the mean lysine requirement value is [approximately equals] 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] rather than the proposed 1985 FAO/WHO/UNU estimate of the upper range of the requirement, which is 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Objective: Our objective was to explore the 24-h pattern and rate of whole-body lysine [1-[sup.13]C]oxidation and status of whole-body lysine balance in healthy, young adults given an L-amino acid diet supplying either a low lysine intake (14-15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) or an intermediate lysine intake (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) for 6 d before a continuous tracer study with L-[1-[sup.13]C]lysine. Design: Five subjects received the low lysine intake, 6 subjects received the intermediate intake, and all were studied by using a standard 24-h oral tracer protocol that was described earlier for studies at a generous lysine intake. Results: The rate of lysine oxidation was not significantly different between the 12-h fasted and 12-h fed states. The daily oxidation rate ([Bar]x [+ or -] SD) was 27.9 [+ or -] 8.8 and 27.3 [+ or -] 17.6 mg lysine [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] for the low- and intermediate-intake groups, respectively (NS). Daily lysine balance was -12.4 [+ or -] 92 and 1.8 [+ or -] 17.7 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1], respectively (P [is less than] 0.025), for the low and intermediate intakes. The balance was significantly less than zero (P [is less than] 0.001) for the low intake. Conclusion: The FAO/WHO/UNU lysine requirement value is not sufficient to maintain lysine homeostasis in healthy adults. From the results of this and tracer studies done by others, the mean lysine requirement of healthy adults was determined to be 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Am J Clin Nutr 2000;72:122-30. KEY WORDS Lysine, oral tracer studies, amino acids, oxidation, healthy adults
subject
0Lysine--Physiological aspects
1Oxidative stress--Measurement
2United States
31USA
4Nutrition
general
0American Society for Clinical Nutrition, Inc.
1Cengage Learning, Inc.
sourceidgale_ofa
recordidgale_ofa63771877
issn
00002-9165
100029165
rsrctypearticle
creationdate2000
recordtypearticle
addtitleAmerican Journal of Clinical Nutrition
searchscopeOneFile
lsr30VSR-Enriched:[eissn, galeid, pages, pqid, doi]
sort
titleTwenty-four-hour oral tracer studies with L-[1-[sup.13]C]lysine at a low (15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) and intermediate (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) lysine intake in healthy adults.
authorEl - Khoury, Antoine E ; Pereira, Paulo Cm ; Borgonha, Sudhir ; Basile - Filho, Anibal ; Beaumier, Louis ; Wang, San Y ; Metges, Cornelia C ; Ajami, Alfred M ; Young, Vernon R
creationdate20000701
facets
frbrgroupid7503761341030404693
frbrtype5
creationdate2000
topic
0Lysine–Physiological Aspects
1Oxidative Stress–Measurement
2Nutritional Requirements
collectionOneFile (GALE)
prefilterarticles
rsrctypearticles
creatorcontrib
0El - Khoury, Antoine E
1Pereira, Paulo Cm
2Borgonha, Sudhir
3Basile - Filho, Anibal
4Beaumier, Louis
5Wang, San Y
6Metges, Cornelia C
7Ajami, Alfred M
8Young, Vernon R
jtitleAmerican Journal of Clinical Nutrition
toplevelpeer_reviewed
frbr
t2
k12000
k200029165
k472
k51
k6122
k7american journal of clinical nutrition
k8twenty four hour oral tracer studies with l 1 sup13 c lysine at low 15 mg multiplied by kgsup 1 multiplied by dsup 1 intermediate 29 mg multiplied by kgsup 1 multiplied by dsup 1 lysine intake in healthy adults
k9twentyfourhouroraltrdults
k12twentyfourhouroraltracers
k15antoineeelkhoury
k16elkhouryantoinee
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typeaggregator
addata
au
0El-Khoury, Antoine E
1Pereira, Paulo CM
2Borgonha, Sudhir
3Basile-Filho, Anibal
4Beaumier, Louis
5Wang, San Y
6Metges, Cornelia C
7Ajami, Alfred M
8Young, Vernon R
atitleTwenty-four-hour oral tracer studies with L-[1-[sup.13]C]lysine at a low (15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) and intermediate (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) lysine intake in healthy adults.
jtitleAmerican Journal of Clinical Nutrition
risdate20000701
volume72
issue1
spage122
issn0002-9165
genrearticle
ristypeJOUR
abstractBackground: We proposed previously that the mean lysine requirement value is [approximately equals] 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] rather than the proposed 1985 FAO/WHO/UNU estimate of the upper range of the requirement, which is 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Objective: Our objective was to explore the 24-h pattern and rate of whole-body lysine [1-[sup.13]C]oxidation and status of whole-body lysine balance in healthy, young adults given an L-amino acid diet supplying either a low lysine intake (14-15 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) or an intermediate lysine intake (29 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]) for 6 d before a continuous tracer study with L-[1-[sup.13]C]lysine. Design: Five subjects received the low lysine intake, 6 subjects received the intermediate intake, and all were studied by using a standard 24-h oral tracer protocol that was described earlier for studies at a generous lysine intake. Results: The rate of lysine oxidation was not significantly different between the 12-h fasted and 12-h fed states. The daily oxidation rate ([Bar]x [+ or -] SD) was 27.9 [+ or -] 8.8 and 27.3 [+ or -] 17.6 mg lysine [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] for the low- and intermediate-intake groups, respectively (NS). Daily lysine balance was -12.4 [+ or -] 92 and 1.8 [+ or -] 17.7 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1], respectively (P [is less than] 0.025), for the low and intermediate intakes. The balance was significantly less than zero (P [is less than] 0.001) for the low intake. Conclusion: The FAO/WHO/UNU lysine requirement value is not sufficient to maintain lysine homeostasis in healthy adults. From the results of this and tracer studies done by others, the mean lysine requirement of healthy adults was determined to be 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Am J Clin Nutr 2000;72:122-30. KEY WORDS Lysine, oral tracer studies, amino acids, oxidation, healthy adults
pubAmerican Society for Clinical Nutrition, Inc.
lad01gale_ofa
pages122-12230
doi10.1093/ajcn/72.1.122
eissn19383207
date2000-07-01