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Prospective study of dietary fat and the risk of age-related macular degeneration

Background: The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear. Objective: Our objective was to examine prospectively the association between fat intake and AMD. Design: We conducted a prospective follow-up study of particip... Full description

Journal Title: American Journal of Clinical Nutrition Feb, 2001, Vol.73(2), p.209
Main Author: Cho, Eunyoung
Other Authors: Hung, Shirley , Willett, Walter C , Spiegelman, Donna , Rimm, Eric B , Seddon, Johanna M , Colditz, Graham A , Hankinson, Susan E
Format: Electronic Article Electronic Article
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Eye
ID: ISSN: 0002-9165
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recordid: gale_ofa70695106
title: Prospective study of dietary fat and the risk of age-related macular degeneration
format: Article
creator:
  • Cho, Eunyoung
  • Hung, Shirley
  • Willett, Walter C
  • Spiegelman, Donna
  • Rimm, Eric B
  • Seddon, Johanna M
  • Colditz, Graham A
  • Hankinson, Susan E
subjects:
  • Retinal Degeneration -- Risk Factors
  • Dietary Fat -- Health Aspects
  • Aging (Biology)
  • Eye
  • Nutritional Assessment
ispartof: American Journal of Clinical Nutrition, Feb, 2001, Vol.73(2), p.209
description: Background: The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear. Objective: Our objective was to examine prospectively the association between fat intake and AMD. Design: We conducted a prospective follow-up study of participants in the Nurses' Health Study and the Health Professionals Follow-up Study. At baseline (1984 for women and 1986 for men), the study included 42743 women and 29746 men aged [is greater than or equal to]50 y with no diagnosis of AMD who were followed until 1996. Fat intake was assessed with a food-frequency questionnaire. Results: We accrued 567 patients with AMD with a visual loss of 20/30 or worse. The pooled multivariate relative risk (RR) for the highest compared with the lowest quintile of total fat intake was 1.54 (95% CI: 1.17, 2.01; P for trend = 0.008). Linolenic acid was positively associated with risk of AMD (top versus bottom quintile of RR: 1.49; 95% CI: 1.15, 1.94; P for trend = 0.0009). Docosahexaenoic acid had a modest inverse relation with AMD (top versus bottom quintile of RR: 0.70; 95% CI: 0.52, 0.93; P for trend = 0.05), and [is greater than]4 servings of fish/wk was associated with a 35% lower risk of AMD compared with [is less than or equal to]3 servings/mo (RR: 0.65; 95% CI: 0.46, 0.91; P for trend = 0.009). Conclusions: Total fat intake was positively associated with risk of AMD, which may have been due to intakes of individual fatty acids, such as linolenic acid, rather than to total fat intakes per se. A high intake of fish may reduce the risk of AMD. Am J Clin Nutr 2001;73:209-18. KEY WORDS Age-related macular degeneration, diet, fats, fatty acids, fish, food-frequency questionnaire, Health Professionals Follow-up Study, men, Nurses' Health Study, prospective studies, women
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identifier: ISSN: 0002-9165
fulltext: fulltext
issn:
  • 0002-9165
  • 00029165
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titleProspective study of dietary fat and the risk of age-related macular degeneration
creatorCho, Eunyoung ; Hung, Shirley ; Willett, Walter C ; Spiegelman, Donna ; Rimm, Eric B ; Seddon, Johanna M ; Colditz, Graham A ; Hankinson, Susan E
ispartofAmerican Journal of Clinical Nutrition, Feb, 2001, Vol.73(2), p.209
identifierISSN: 0002-9165
subjectRetinal Degeneration -- Risk Factors ; Dietary Fat -- Health Aspects ; Aging (Biology) ; Eye ; Nutritional Assessment
descriptionBackground: The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear. Objective: Our objective was to examine prospectively the association between fat intake and AMD. Design: We conducted a prospective follow-up study of participants in the Nurses' Health Study and the Health Professionals Follow-up Study. At baseline (1984 for women and 1986 for men), the study included 42743 women and 29746 men aged [is greater than or equal to]50 y with no diagnosis of AMD who were followed until 1996. Fat intake was assessed with a food-frequency questionnaire. Results: We accrued 567 patients with AMD with a visual loss of 20/30 or worse. The pooled multivariate relative risk (RR) for the highest compared with the lowest quintile of total fat intake was 1.54 (95% CI: 1.17, 2.01; P for trend = 0.008). Linolenic acid was positively associated with risk of AMD (top versus bottom quintile of RR: 1.49; 95% CI: 1.15, 1.94; P for trend = 0.0009). Docosahexaenoic acid had a modest inverse relation with AMD (top versus bottom quintile of RR: 0.70; 95% CI: 0.52, 0.93; P for trend = 0.05), and [is greater than]4 servings of fish/wk was associated with a 35% lower risk of AMD compared with [is less than or equal to]3 servings/mo (RR: 0.65; 95% CI: 0.46, 0.91; P for trend = 0.009). Conclusions: Total fat intake was positively associated with risk of AMD, which may have been due to intakes of individual fatty acids, such as linolenic acid, rather than to total fat intakes per se. A high intake of fish may reduce the risk of AMD. Am J Clin Nutr 2001;73:209-18. KEY WORDS Age-related macular degeneration, diet, fats, fatty acids, fish, food-frequency questionnaire, Health Professionals Follow-up Study, men, Nurses' Health Study, prospective studies, women
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titleProspective study of dietary fat and the risk of age-related macular degeneration.
descriptionBackground: The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear. Objective: Our objective was to examine prospectively the association between fat intake and AMD. Design: We conducted a prospective follow-up study of participants in the Nurses' Health Study and the Health Professionals Follow-up Study. At baseline (1984 for women and 1986 for men), the study included 42743 women and 29746 men aged [is greater than or equal to]50 y with no diagnosis of AMD who were followed until 1996. Fat intake was assessed with a food-frequency questionnaire. Results: We accrued 567 patients with AMD with a visual loss of 20/30 or worse. The pooled multivariate relative risk (RR) for the highest compared with the lowest quintile of total fat intake was 1.54 (95% CI: 1.17, 2.01; P for trend = 0.008). Linolenic acid was positively associated with risk of AMD (top versus bottom quintile of RR: 1.49; 95% CI: 1.15, 1.94; P for trend = 0.0009). Docosahexaenoic acid had a modest inverse relation with AMD (top versus bottom quintile of RR: 0.70; 95% CI: 0.52, 0.93; P for trend = 0.05), and [is greater than]4 servings of fish/wk was associated with a 35% lower risk of AMD compared with [is less than or equal to]3 servings/mo (RR: 0.65; 95% CI: 0.46, 0.91; P for trend = 0.009). Conclusions: Total fat intake was positively associated with risk of AMD, which may have been due to intakes of individual fatty acids, such as linolenic acid, rather than to total fat intakes per se. A high intake of fish may reduce the risk of AMD. Am J Clin Nutr 2001;73:209-18. KEY WORDS Age-related macular degeneration, diet, fats, fatty acids, fish, food-frequency questionnaire, Health Professionals Follow-up Study, men, Nurses' Health Study, prospective studies, women
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abstractBackground: The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear. Objective: Our objective was to examine prospectively the association between fat intake and AMD. Design: We conducted a prospective follow-up study of participants in the Nurses' Health Study and the Health Professionals Follow-up Study. At baseline (1984 for women and 1986 for men), the study included 42743 women and 29746 men aged [is greater than or equal to]50 y with no diagnosis of AMD who were followed until 1996. Fat intake was assessed with a food-frequency questionnaire. Results: We accrued 567 patients with AMD with a visual loss of 20/30 or worse. The pooled multivariate relative risk (RR) for the highest compared with the lowest quintile of total fat intake was 1.54 (95% CI: 1.17, 2.01; P for trend = 0.008). Linolenic acid was positively associated with risk of AMD (top versus bottom quintile of RR: 1.49; 95% CI: 1.15, 1.94; P for trend = 0.0009). Docosahexaenoic acid had a modest inverse relation with AMD (top versus bottom quintile of RR: 0.70; 95% CI: 0.52, 0.93; P for trend = 0.05), and [is greater than]4 servings of fish/wk was associated with a 35% lower risk of AMD compared with [is less than or equal to]3 servings/mo (RR: 0.65; 95% CI: 0.46, 0.91; P for trend = 0.009). Conclusions: Total fat intake was positively associated with risk of AMD, which may have been due to intakes of individual fatty acids, such as linolenic acid, rather than to total fat intakes per se. A high intake of fish may reduce the risk of AMD. Am J Clin Nutr 2001;73:209-18. KEY WORDS Age-related macular degeneration, diet, fats, fatty acids, fish, food-frequency questionnaire, Health Professionals Follow-up Study, men, Nurses' Health Study, prospective studies, women
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