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Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.(Report)

The high-resolution structure of an intramolecular complex between (3 + 1) human telomeric G-quadruplex and a telomestatin derivative, the macrocyclic hexaoxazole L2H2-6M(2)OTD, is described. The results revealed pi-stacking and electrostatic interactions between G-quadruplex and the telomestatin de... Full description

Journal Title: Journal of the American Chemical Society Sept 11, 2013, Vol.135(36), p.13495-13501
Main Author: Wan Jun Chung
Other Authors: Heddi, Brahim , Tera, Masayuki , Iida, Keisuke , Nagasawa, Kazuo , Anh Tuan Phan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-7863
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title: Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.(Report)
format: Article
creator:
  • Wan Jun Chung
  • Heddi, Brahim
  • Tera, Masayuki
  • Iida, Keisuke
  • Nagasawa, Kazuo
  • Anh Tuan Phan
subjects:
  • Antineoplastic Agents -- Research
  • Molecular Dynamics -- Analysis
  • Protein Structure -- Research
  • Protein-protein Interactions -- Analysis
ispartof: Journal of the American Chemical Society, Sept 11, 2013, Vol.135(36), p.13495-13501
description: The high-resolution structure of an intramolecular complex between (3 + 1) human telomeric G-quadruplex and a telomestatin derivative, the macrocyclic hexaoxazole L2H2-6M(2)OTD, is described. The results revealed pi-stacking and electrostatic interactions between G-quadruplex and the telomestatin derivative.
language: English
source:
identifier: ISSN: 0002-7863
fulltext: no_fulltext
issn:
  • 0002-7863
  • 00027863
url: Link


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titleSolution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.(Report)
creatorWan Jun Chung ; Heddi, Brahim ; Tera, Masayuki ; Iida, Keisuke ; Nagasawa, Kazuo ; Anh Tuan Phan
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identifierISSN: 0002-7863
subjectAntineoplastic Agents -- Research ; Molecular Dynamics -- Analysis ; Protein Structure -- Research ; Protein-protein Interactions -- Analysis
descriptionThe high-resolution structure of an intramolecular complex between (3 + 1) human telomeric G-quadruplex and a telomestatin derivative, the macrocyclic hexaoxazole L2H2-6M(2)OTD, is described. The results revealed pi-stacking and electrostatic interactions between G-quadruplex and the telomestatin derivative.
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titleSolution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.(Report)
descriptionThe high-resolution structure of an intramolecular complex between (3 + 1) human telomeric G-quadruplex and a telomestatin derivative, the macrocyclic hexaoxazole L2H2-6M(2)OTD, is described. The results revealed pi-stacking and electrostatic interactions between G-quadruplex and the telomestatin derivative.
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titleSolution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.(Report)
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abstractThe high-resolution structure of an intramolecular complex between (3 + 1) human telomeric G-quadruplex and a telomestatin derivative, the macrocyclic hexaoxazole L2H2-6M(2)OTD, is described. The results revealed pi-stacking and electrostatic interactions between G-quadruplex and the telomestatin derivative.
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