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Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China

Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR... Full description

Journal Title: SCIENTIFIC REPORTS 2017
Main Author: Lou, Hongfei
Other Authors: Ma, Siyuan , Zhao, Yan , Cao, Feifei , He, Fei , Liu, Zhongyan , Bousquet, Jean , Wang, Chengshuo , Zhang, Luo , Bachert, Claus
Format: Electronic Article Electronic Article
Language: English
Subjects:
Created: 2017
ID: ISSN: 2045-2322 ; DOI: 10.10.8/s41598-017-10.11-9
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recordid: ghent8538881
title: Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
format: Article
creator:
  • Lou, Hongfei
  • Ma, Siyuan
  • Zhao, Yan
  • Cao, Feifei
  • He, Fei
  • Liu, Zhongyan
  • Bousquet, Jean
  • Wang, Chengshuo
  • Zhang, Luo
  • Bachert, Claus
subjects:
  • Medicine And Health Sciences
  • Ga2len Skin-Test
  • Common Aeroallergens
  • Inhalant Allergens
  • Clinical-Relevance
  • Prevalence
  • Asthma
  • Cities
  • Classification
  • Population
  • Europe
ispartof: SCIENTIFIC REPORTS, 2017
description: Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Koppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT. 6340 (88.7%) patients had at least one positive skin prick reaction, and demonstrated unique sensitization patterns by stratification with age, gender, and geographic region. Sensitization to house dust mites (HDM) was highest in south China, whereas the three most prevalent aeroallergens were mugwort, ragweed and dandelion pollen in north-west China. Higher sensitization rates and multiple sensitizations were associated with AR comorbidities. Eight allergens (Der f, mugwort, Blatella, hazel, goosefoot, Penicillium notatum, animal dander and Der p) allowed identification > 96% of sensitized subjects in central China. Differences in optimal panels were observed between regions, with five to six allergens being sufficient for north-east, north-west and south China. These SPT panels may provide a cost-effective tool for screening sensitized patients in China.
language: eng
source:
identifier: ISSN: 2045-2322 ; DOI: 10.10.8/s41598-017-10.11-9
fulltext: fulltext_linktorsrc
issn:
  • 2045 2322
  • 2045-2322
url: Link


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titleSensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
creatorLou, Hongfei ; Ma, Siyuan ; Zhao, Yan ; Cao, Feifei ; He, Fei ; Liu, Zhongyan ; Bousquet, Jean ; Wang, Chengshuo ; Zhang, Luo ; Bachert, Claus
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identifier ISSN: 2045-2322 ; DOI: 10.10.8/s41598-017-10.11-9
subjectMedicine And Health Sciences ; Ga2len Skin-Test ; Common Aeroallergens ; Inhalant Allergens ; Clinical-Relevance ; Prevalence ; Asthma ; Cities ; Classification ; Population ; Europe
descriptionOptimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Koppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT. 6340 (88.7%) patients had at least one positive skin prick reaction, and demonstrated unique sensitization patterns by stratification with age, gender, and geographic region. Sensitization to house dust mites (HDM) was highest in south China, whereas the three most prevalent aeroallergens were mugwort, ragweed and dandelion pollen in north-west China. Higher sensitization rates and multiple sensitizations were associated with AR comorbidities. Eight allergens (Der f, mugwort, Blatella, hazel, goosefoot, Penicillium notatum, animal dander and Der p) allowed identification > 96% of sensitized subjects in central China. Differences in optimal panels were observed between regions, with five to six allergens being sufficient for north-east, north-west and south China. These SPT panels may provide a cost-effective tool for screening sensitized patients in China.
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titleSensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
descriptionOptimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Koppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT. 6340 (88.7%) patients had at least one positive skin prick reaction, and demonstrated unique sensitization patterns by stratification with age, gender, and geographic region. Sensitization to house dust mites (HDM) was highest in south China, whereas the three most prevalent aeroallergens were mugwort, ragweed and dandelion pollen in north-west China. Higher sensitization rates and multiple sensitizations were associated with AR comorbidities. Eight allergens (Der f, mugwort, Blatella, hazel, goosefoot, Penicillium notatum, animal dander and Der p) allowed identification > 96% of sensitized subjects in central China. Differences in optimal panels were observed between regions, with five to six allergens being sufficient for north-east, north-west and south China. These SPT panels may provide a cost-effective tool for screening sensitized patients in China.
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abstractOptimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Koppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT. 6340 (88.7%) patients had at least one positive skin prick reaction, and demonstrated unique sensitization patterns by stratification with age, gender, and geographic region. Sensitization to house dust mites (HDM) was highest in south China, whereas the three most prevalent aeroallergens were mugwort, ragweed and dandelion pollen in north-west China. Higher sensitization rates and multiple sensitizations were associated with AR comorbidities. Eight allergens (Der f, mugwort, Blatella, hazel, goosefoot, Penicillium notatum, animal dander and Der p) allowed identification > 96% of sensitized subjects in central China. Differences in optimal panels were observed between regions, with five to six allergens being sufficient for north-east, north-west and south China. These SPT panels may provide a cost-effective tool for screening sensitized patients in China.
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