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Comparative Analysis of Quinolone Resistance in Clinical Isolates of and from Chinese Children and Adults

The objective of this study was to compare quinolone resistance and mutations in clinical isolates of and from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration. The antimicrobial susceptibilities of 61 isolates from children... Full description

Journal Title: BioMed Research International 2015, Vol.2015, 6 pages
Main Author: Huang, Ying
Other Authors: Ogutu, James O , Gu, Jiarui , Ding, Fengshu , You, Yuhong , Huo, Yan , Zhao, Hong , Li, Wenjing , Zhang, Zhiwei , Zhang, Wenli , Chen, Xiaobei , Fu, Yingmei , Zhang, Fengmin
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ID: ISSN: 2314-6133 ; E-ISSN: 2314-6141 ; DOI: 10.1155/2015/168292
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recordid: hindawi10.1155/2015/168292
title: Comparative Analysis of Quinolone Resistance in Clinical Isolates of and from Chinese Children and Adults
format: Article
creator:
  • Huang, Ying
  • Ogutu, James O
  • Gu, Jiarui
  • Ding, Fengshu
  • You, Yuhong
  • Huo, Yan
  • Zhao, Hong
  • Li, Wenjing
  • Zhang, Zhiwei
  • Zhang, Wenli
  • Chen, Xiaobei
  • Fu, Yingmei
  • Zhang, Fengmin
subjects:
  • Research Article
ispartof: BioMed Research International, 2015, Vol.2015, 6 pages
description: The objective of this study was to compare quinolone resistance and mutations in clinical isolates of and from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration. The antimicrobial susceptibilities of 61 isolates from children and 79 isolates from adults were determined. The mutations in the quinolone resistance-determining regions in gene were detected by PCR and DNA sequencing. Fluoroquinolone resistance and types of mutations in isolates from children and adults were compared and statistically analyzed. No significant differences were detected in the resistance rates of ciprofloxacin and levofloxacin between children and adults among isolates of the two species (all ). The double mutation Ser83Leu + Asp87Asn in the ciprofloxacin-resistant isolates occurred in 73.7% isolates from the children and 67.9% from the adults, respectively (). Children with no known history of quinolone administration were found to carry fluoroquinolone-resistant isolates. The occurrence of ciprofloxacin resistance and the major types of mutations in the isolates from the children were similar to those from adults. The results indicate that precautions should be taken on environmental issues resulting from widespread transmission of quinolone resistance.
language:
source:
identifier: ISSN: 2314-6133 ; E-ISSN: 2314-6141 ; DOI: 10.1155/2015/168292
fulltext: fulltext
issn:
  • 2314-6133
  • 23146133
  • 2314-6141
  • 23146141
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titleComparative Analysis of Quinolone Resistance in Clinical Isolates of and from Chinese Children and Adults
creatorHuang, Ying ; Ogutu, James O ; Gu, Jiarui ; Ding, Fengshu ; You, Yuhong ; Huo, Yan ; Zhao, Hong ; Li, Wenjing ; Zhang, Zhiwei ; Zhang, Wenli ; Chen, Xiaobei ; Fu, Yingmei ; Zhang, Fengmin
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descriptionThe objective of this study was to compare quinolone resistance and mutations in clinical isolates of and from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration. The antimicrobial susceptibilities of 61 isolates from children and 79 isolates from adults were determined. The mutations in the quinolone resistance-determining regions in gene were detected by PCR and DNA sequencing. Fluoroquinolone resistance and types of mutations in isolates from children and adults were compared and statistically analyzed. No significant differences were detected in the resistance rates of ciprofloxacin and levofloxacin between children and adults among isolates of the two species (all ). The double mutation Ser83Leu + Asp87Asn in the ciprofloxacin-resistant isolates occurred in 73.7% isolates from the children and 67.9% from the adults, respectively (). Children with no known history of quinolone administration were found to carry fluoroquinolone-resistant isolates. The occurrence of ciprofloxacin resistance and the major types of mutations in the isolates from the children were similar to those from adults. The results indicate that precautions should be taken on environmental issues resulting from widespread transmission of quinolone resistance.
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abstractThe objective of this study was to compare quinolone resistance and mutations in clinical isolates of and from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration. The antimicrobial susceptibilities of 61 isolates from children and 79 isolates from adults were determined. The mutations in the quinolone resistance-determining regions in gene were detected by PCR and DNA sequencing. Fluoroquinolone resistance and types of mutations in isolates from children and adults were compared and statistically analyzed. No significant differences were detected in the resistance rates of ciprofloxacin and levofloxacin between children and adults among isolates of the two species (all ). The double mutation Ser83Leu + Asp87Asn in the ciprofloxacin-resistant isolates occurred in 73.7% isolates from the children and 67.9% from the adults, respectively (). Children with no known history of quinolone administration were found to carry fluoroquinolone-resistant isolates. The occurrence of ciprofloxacin resistance and the major types of mutations in the isolates from the children were similar to those from adults. The results indicate that precautions should be taken on environmental issues resulting from widespread transmission of quinolone resistance.
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