schliessen

Filtern

 

Bibliotheken

Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumonia

. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients.. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical seve... Full description

Journal Title: Journal of Immunology Research 2016, Vol.2016, 10 pages
Main Author: Sun, Jia
Other Authors: Su, Junwei , Xie, Yirui , Yin, Michael T , Huang, Ying , Xu, Lijun , Zhou, Qihui , Zhu, Biao
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 2314-8861 ; E-ISSN: 2314-7156 ; DOI: 10.1155/2016/1583951
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: hindawi10.1155/2016/1583951
title: Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumonia
format: Article
creator:
  • Sun, Jia
  • Su, Junwei
  • Xie, Yirui
  • Yin, Michael T
  • Huang, Ying
  • Xu, Lijun
  • Zhou, Qihui
  • Zhu, Biao
subjects:
  • Interleukin 6
  • Blood
  • Mortality
  • Death
  • Acquired Immune Deficiency Syndrome
  • Oxygenation
  • Ferritin
  • Biomarkers
  • Pneumonia
  • Interleukin 10
  • Interleukin 8
  • Inflammation
  • Lentivirus
  • Human Immunodeficiency Virus
  • Pneumoviridae
  • Retroviridae
  • Pneumocystis
  • Human Diseases
  • AIDS and HIV
  • Microorganisms & Parasites
ispartof: Journal of Immunology Research, 2016, Vol.2016, 10 pages
description: . To identify blood biomarkers to predict severity and mortality in AIDS PCP patients.. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve.. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (, ), HBDH (, ), and Ferritin (, ). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO/FiO ≤ 200 mmHg and nonsurvivors than in those with PaO/FiO > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, ; 1.11 ± 0.72, ), larger AUC (95% CI 0.781–1.000, ; 95% CI 0.592–0.917, ), and more significantly inverse correlation with the oxygenation index.. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.
language:
source:
identifier: ISSN: 2314-8861 ; E-ISSN: 2314-7156 ; DOI: 10.1155/2016/1583951
fulltext: fulltext
issn:
  • 2314-8861
  • 23148861
  • 2314-7156
  • 23147156
url: Link


@attributes
ID724474297
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1155/2016/1583951
sourceidhindawi
recordidTN_hindawi10.1155/2016/1583951
sourceformatXML
sourcesystemPC
pqid1819145127
display
typearticle
titlePlasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumonia
creatorSun, Jia ; Su, Junwei ; Xie, Yirui ; Yin, Michael T ; Huang, Ying ; Xu, Lijun ; Zhou, Qihui ; Zhu, Biao
contributorNistico, Paola
ispartofJournal of Immunology Research, 2016, Vol.2016, 10 pages
identifier
description. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients.. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve.. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (, ), HBDH (, ), and Ferritin (, ). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO/FiO ≤ 200 mmHg and nonsurvivors than in those with PaO/FiO > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, ; 1.11 ± 0.72, ), larger AUC (95% CI 0.781–1.000, ; 95% CI 0.592–0.917, ), and more significantly inverse correlation with the oxygenation index.. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.
source
subjectInterleukin 6 ; Blood ; Mortality ; Death ; Acquired Immune Deficiency Syndrome ; Oxygenation ; Ferritin ; Biomarkers ; Pneumonia ; Interleukin 10 ; Interleukin 8 ; Inflammation ; Lentivirus ; Human Immunodeficiency Virus ; Pneumoviridae ; Retroviridae ; Pneumocystis ; Human Diseases ; AIDS and HIV ; Microorganisms & Parasites;
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Sun, Jia
1Nistico, Paola
2Su, Junwei
3Xie, Yirui
4Yin, Michael T.
5Huang, Ying
6Xu, Lijun
7Zhou, Qihui
8Zhu, Biao
titlePlasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumonia
description. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients.. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve.. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (, ), HBDH (, ), and Ferritin (, ). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO/FiO ≤ 200 mmHg and nonsurvivors than in those with PaO/FiO > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, ; 1.11 ± 0.72, ), larger AUC (95% CI 0.781–1.000, ; 95% CI 0.592–0.917, ), and more significantly inverse correlation with the oxygenation index.. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.
general10.1155/2016/1583951
sourceidhindawi
recordidhindawi10.1155/2016/1583951
issn
02314-8861
123148861
22314-7156
323147156
rsrctypearticle
creationdate2016
addtitleJournal of Immunology Research
searchscope
0hindawi
1FREE
2Hindawi Journals
scope
0hindawi
1FREE
2Hindawi Journals
lsr30VSR-Enriched:[orcidid, subject, pqid]
sort
titlePlasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumonia
authorSun, Jia ; Su, Junwei ; Xie, Yirui ; Yin, Michael T ; Huang, Ying ; Xu, Lijun ; Zhou, Qihui ; Zhu, Biao
creationdate20160000
facets
frbrgroupid5209809908572589367
frbrtype5
creationdate2016
collectionHindawi Journals
prefilterarticles
rsrctypearticles
creatorcontrib
0Sun, Jia
1Nistico, Paola
2Su, Junwei
3Xie, Yirui
4Yin, Michael T
5Huang, Ying
6Xu, Lijun
7Zhou, Qihui
8Zhu, Biao
jtitleJournal of Immunology Research
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Sun
1Su
2Xie
3Yin
4Huang
5Xu
6Zhou
7Zhu
aufirst
0Jia
1Junwei
2Yirui
3Michael T
4Ying
5Lijun
6Qihui
7Biao
au
0Sun, Jia
1Su, Junwei
2Xie, Yirui
3Yin, Michael T.
4Huang, Ying
5Xu, Lijun
6Zhou, Qihui
7Zhu, Biao
atitlePlasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumonia
jtitleJournal of Immunology Research
date2016
volume2016
pages10
issn2314-8861
eissn2314-7156
formatjournal
genrearticle
ristypeJOUR
abstract. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients.. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve.. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (, ), HBDH (, ), and Ferritin (, ). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO/FiO ≤ 200 mmHg and nonsurvivors than in those with PaO/FiO > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, ; 1.11 ± 0.72, ), larger AUC (95% CI 0.781–1.000, ; 95% CI 0.592–0.917, ), and more significantly inverse correlation with the oxygenation index.. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.
pubHindawi Publishing Corporation
doi10.1155/2016/1583951
orcidid0000-0001-6288-4575
oafree_for_read