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Insight into eukaryotic topoisomerase II-inhibiting fused heterocyclic compounds in human cancer cell lines by molecular docking

Etoposide is effective as an anti-tumour drug by inhibiting eukaryotic DNA topoisomerase II via establishing a covalent complex with DNA. Unfortunately, its wide therapeutic application is often hindered by multidrug resistance (MDR), low water solubility and toxicity. In our previous study,...

Journal Title: SAR and QSAR in Environmental Research 01 April 2012, Vol.23(3-4), pp.345-355
Main Author: Taskin, T
Other Authors: Yilmaz, S , Yildiz, I , Yalcin, I , Aki, E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1062-936X ; E-ISSN: 1029-046X ; DOI: 10.1080/1062936X.2012.664560
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title: Insight into eukaryotic topoisomerase II-inhibiting fused heterocyclic compounds in human cancer cell lines by molecular docking
format: Article
creator:
  • Taskin, T
  • Yilmaz, S
  • Yildiz, I
  • Yalcin, I
  • Aki, E
subjects:
  • Topoisomerase II
  • Benzoxazoles
  • Benzimidazoles
  • Benzothiazoles
  • Molecular Docking
  • Environmental Sciences
  • Anatomy & Physiology
ispartof: SAR and QSAR in Environmental Research, 01 April 2012, Vol.23(3-4), pp.345-355
description: Etoposide is effective as an anti-tumour drug by inhibiting eukaryotic DNA topoisomerase II via establishing a covalent complex with DNA. Unfortunately, its wide therapeutic application is often hindered by multidrug resistance (MDR), low water solubility and toxicity. In our previous study,...
language: eng
source:
identifier: ISSN: 1062-936X ; E-ISSN: 1029-046X ; DOI: 10.1080/1062936X.2012.664560
fulltext: fulltext
issn:
  • 1062-936X
  • 1062936X
  • 1029-046X
  • 1029046X
url: Link


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titleInsight into eukaryotic topoisomerase II-inhibiting fused heterocyclic compounds in human cancer cell lines by molecular docking
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descriptionEtoposide is effective as an anti-tumour drug by inhibiting eukaryotic DNA topoisomerase II via establishing a covalent complex with DNA. Unfortunately, its wide therapeutic application is often hindered by multidrug resistance (MDR), low water solubility and toxicity. In our previous study,...
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Etoposide is effective as an anti-tumour drug by inhibiting eukaryotic DNA topoisomerase II via establishing a covalent complex with DNA. Unfortunately, its wide therapeutic application is often hindered by multidrug resistance (MDR), low water solubility and toxicity. In our previous study,...

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Etoposide is effective as an anti-tumour drug by inhibiting eukaryotic DNA topoisomerase II via establishing a covalent complex with DNA. Unfortunately, its wide therapeutic application is often hindered by multidrug resistance (MDR), low water solubility and toxicity. In our previous study,...

pubTaylor & Francis Group
doi10.1080/1062936X.2012.664560
urlhttp://www.tandfonline.com/doi/abs/10.1080/1062936X.2012.664560
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