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Pharmacophore generation of 2-substituted benzothiazoles as AdeABC efflux pump inhibitors in A. baumannii

RND family efflux pumps are important for multidrug resistance in Gram-negative bacteria. To date no efflux pump inhibitors for clinical use have been found, so developing the specific inhibitors of this pump system will be beneficial for the treatment of infections caused by these multidrug-resista... Full description

Journal Title: SAR and QSAR in Environmental Research 03 July 2014, Vol.25(7), pp.551-563
Main Author: Yilmaz, S
Other Authors: Altinkanat-Gelmez, G , Bolelli, K , Guneser-Merdan, D , Over-Hasdemir, M.U , Yildiz, I , Aki-Yalcin, E , Yalcin, I
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1062-936X ; E-ISSN: 1029-046X ; DOI: 10.1080/1062936X.2014.919357
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recordid: informaworld_s10_1080_1062936X_2014_919357
title: Pharmacophore generation of 2-substituted benzothiazoles as AdeABC efflux pump inhibitors in A. baumannii
format: Article
creator:
  • Yilmaz, S
  • Altinkanat-Gelmez, G
  • Bolelli, K
  • Guneser-Merdan, D
  • Over-Hasdemir, M.U
  • Yildiz, I
  • Aki-Yalcin, E
  • Yalcin, I
subjects:
  • Benzothiazoles
  • A. Baumannii Sbmox-2
  • Adeabc
  • Ciprofloxacin
  • Hiphop
  • Pharmacophore Generation
  • Environmental Sciences
  • Anatomy & Physiology
ispartof: SAR and QSAR in Environmental Research, 03 July 2014, Vol.25(7), pp.551-563
description: RND family efflux pumps are important for multidrug resistance in Gram-negative bacteria. To date no efflux pump inhibitors for clinical use have been found, so developing the specific inhibitors of this pump system will be beneficial for the treatment of infections caused by these multidrug-resistant...
language: eng
source:
identifier: ISSN: 1062-936X ; E-ISSN: 1029-046X ; DOI: 10.1080/1062936X.2014.919357
fulltext: fulltext
issn:
  • 1062-936X
  • 1062936X
  • 1029-046X
  • 1029046X
url: Link


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titlePharmacophore generation of 2-substituted benzothiazoles as AdeABC efflux pump inhibitors in A. baumannii
creatorYilmaz, S ; Altinkanat-Gelmez, G ; Bolelli, K ; Guneser-Merdan, D ; Over-Hasdemir, M.U ; Yildiz, I ; Aki-Yalcin, E ; Yalcin, I
ispartofSAR and QSAR in Environmental Research, 03 July 2014, Vol.25(7), pp.551-563
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subjectBenzothiazoles ; A. Baumannii Sbmox-2 ; Adeabc ; Ciprofloxacin ; Hiphop ; Pharmacophore Generation ; Environmental Sciences ; Anatomy & Physiology
descriptionRND family efflux pumps are important for multidrug resistance in Gram-negative bacteria. To date no efflux pump inhibitors for clinical use have been found, so developing the specific inhibitors of this pump system will be beneficial for the treatment of infections caused by these multidrug-resistant...
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RND family efflux pumps are important for multidrug resistance in Gram-negative bacteria. To date no efflux pump inhibitors for clinical use have been found, so developing the specific inhibitors of this pump system will be beneficial for the treatment of infections caused by these multidrug-resistant...

pubTaylor & Francis
doi10.1080/1062936X.2014.919357
urlhttp://www.tandfonline.com/doi/abs/10.1080/1062936X.2014.919357
lad01SAR and QSAR in Environmental Research
date2014-07-03