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Effects of pentoxifylline on gentamicin-induced nephrotoxicity

We aimed to investigate the underlying mechanisms responsible for the renoprotective effects of pentoxifylline (PTX) in gentamicin (GEN)-induced nephropathy. On this purpose, 26 female Wistar rats (200-250 g) were included and four groups were formed. The first one was the control group (n:5). The r... Full description

Journal Title: Renal Failure 01 November 2013, Vol.35(10), pp.1376-1381
Main Author: Kasap, Belde
Other Authors: Türkmen, Mehmet , Kiray, Müge , Kuralay, Filiz , Soylu, Alper , Tuğyan, Kazım , Kavukçu, Salih
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0886-022X ; E-ISSN: 1525-6049 ; DOI: 10.3109/0886022X.2013.828359
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recordid: informaworld_s10_3109_0886022X_2013_828359
title: Effects of pentoxifylline on gentamicin-induced nephrotoxicity
format: Article
creator:
  • Kasap, Belde
  • Türkmen, Mehmet
  • Kiray, Müge
  • Kuralay, Filiz
  • Soylu, Alper
  • Tuğyan, Kazım
  • Kavukçu, Salih
subjects:
  • Apoptosis
  • Gentamicin
  • Nephrotoxicity
  • Oxidative Stress
  • Pentoxifylline
  • Medicine
ispartof: Renal Failure, 01 November 2013, Vol.35(10), pp.1376-1381
description: We aimed to investigate the underlying mechanisms responsible for the renoprotective effects of pentoxifylline (PTX) in gentamicin (GEN)-induced nephropathy. On this purpose, 26 female Wistar rats (200-250 g) were included and four groups were formed. The first one was the control group (n:5). The rats in other groups (n:7 for each) received 50 mg/kg twice daily intraperitoneal (i.p.) PTX, 100 mg/kg i.p. GEN and both GEN and PTX at the same doses for consecutive 8 days, respectively. Rats were weighed both at the beginning and end of the study. After the last dose, 24-hour urines were collected and the rats were sacrificed. Blood samples and kidney tissues were obtained for biochemical, histological, oxidative stress, and apoptotic parameters. Body weights were similar in all groups at the beginning of the study. Rats in GEN group had significant weight loss, tubular damage, and increased apoptosis, while GEN + PTX group had significantly better outcomes. Scr, urinary protein/creatinine, and TBARS levels were significantly higher and Ccr and SOD levels were significantly lower in GEN and GEN + PTX groups in comparison to control and PTX groups, but the levels were similar between GEN and GEN + PTX groups. In conclusion, concomitant administration of PTX provides renoprotection via suppressing apoptosis in GEN-induced nephropathy.
language: eng
source:
identifier: ISSN: 0886-022X ; E-ISSN: 1525-6049 ; DOI: 10.3109/0886022X.2013.828359
fulltext: fulltext_linktorsrc
issn:
  • 0886-022X
  • 0886022X
  • 1525-6049
  • 15256049
url: Link


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titleEffects of pentoxifylline on gentamicin-induced nephrotoxicity
creatorKasap, Belde ; Türkmen, Mehmet ; Kiray, Müge ; Kuralay, Filiz ; Soylu, Alper ; Tuğyan, Kazım ; Kavukçu, Salih
ispartofRenal Failure, 01 November 2013, Vol.35(10), pp.1376-1381
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subjectApoptosis ; Gentamicin ; Nephrotoxicity ; Oxidative Stress ; Pentoxifylline ; Medicine
descriptionWe aimed to investigate the underlying mechanisms responsible for the renoprotective effects of pentoxifylline (PTX) in gentamicin (GEN)-induced nephropathy. On this purpose, 26 female Wistar rats (200-250 g) were included and four groups were formed. The first one was the control group (n:5). The rats in other groups (n:7 for each) received 50 mg/kg twice daily intraperitoneal (i.p.) PTX, 100 mg/kg i.p. GEN and both GEN and PTX at the same doses for consecutive 8 days, respectively. Rats were weighed both at the beginning and end of the study. After the last dose, 24-hour urines were collected and the rats were sacrificed. Blood samples and kidney tissues were obtained for biochemical, histological, oxidative stress, and apoptotic parameters. Body weights were similar in all groups at the beginning of the study. Rats in GEN group had significant weight loss, tubular damage, and increased apoptosis, while GEN + PTX group had significantly better outcomes. Scr, urinary protein/creatinine, and TBARS levels were significantly higher and Ccr and SOD levels were significantly lower in GEN and GEN + PTX groups in comparison to control and PTX groups, but the levels were similar between GEN and GEN + PTX groups. In conclusion, concomitant administration of PTX provides renoprotection via suppressing apoptosis in GEN-induced nephropathy.
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titleEffects of pentoxifylline on gentamicin-induced nephrotoxicity
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We aimed to investigate the underlying mechanisms responsible for the renoprotective effects of pentoxifylline (PTX) in gentamicin (GEN)-induced nephropathy. On this purpose, 26 female Wistar rats (200-250 g) were included and four groups were formed. The first one was the control group (n:5). The rats in other groups (n:7 for each) received 50 mg/kg twice daily intraperitoneal (i.p.) PTX, 100 mg/kg i.p. GEN and both GEN and PTX at the same doses for consecutive 8 days, respectively. Rats were weighed both at the beginning and end of the study. After the last dose, 24-hour urines were collected and the rats were sacrificed. Blood samples and kidney tissues were obtained for biochemical, histological, oxidative stress, and apoptotic parameters. Body weights were similar in all groups at the beginning of the study. Rats in GEN group had significant weight loss, tubular damage, and increased apoptosis, while GEN + PTX group had significantly better outcomes. Scr, urinary protein/creatinine, and TBARS levels were significantly higher and Ccr and SOD levels were significantly lower in GEN and GEN + PTX groups in comparison to control and PTX groups, but the levels were similar between GEN and GEN + PTX groups. In conclusion, concomitant administration of PTX provides renoprotection via suppressing apoptosis in GEN-induced nephropathy.

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We aimed to investigate the underlying mechanisms responsible for the renoprotective effects of pentoxifylline (PTX) in gentamicin (GEN)-induced nephropathy. On this purpose, 26 female Wistar rats (200-250 g) were included and four groups were formed. The first one was the control group (n:5). The rats in other groups (n:7 for each) received 50 mg/kg twice daily intraperitoneal (i.p.) PTX, 100 mg/kg i.p. GEN and both GEN and PTX at the same doses for consecutive 8 days, respectively. Rats were weighed both at the beginning and end of the study. After the last dose, 24-hour urines were collected and the rats were sacrificed. Blood samples and kidney tissues were obtained for biochemical, histological, oxidative stress, and apoptotic parameters. Body weights were similar in all groups at the beginning of the study. Rats in GEN group had significant weight loss, tubular damage, and increased apoptosis, while GEN + PTX group had significantly better outcomes. Scr, urinary protein/creatinine, and TBARS levels were significantly higher and Ccr and SOD levels were significantly lower in GEN and GEN + PTX groups in comparison to control and PTX groups, but the levels were similar between GEN and GEN + PTX groups. In conclusion, concomitant administration of PTX provides renoprotection via suppressing apoptosis in GEN-induced nephropathy.

pubTaylor & Francis
doi10.3109/0886022X.2013.828359
urlhttp://www.tandfonline.com/doi/abs/10.3109/0886022X.2013.828359
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date2013-11-01