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Effects of prenatal diclofenac sodium exposure on newborn testis: a histomorphometric study

Diclofenac sodium (DS) is used primarily to treat fever and to alleviate pain and inflammation. We investigated the effects of DS exposure during gestation on the testes of rat pups to investigate the safety of its use during the prenatal period. Pregnant rats were separated into control, saline, lo... Full description

Journal Title: Biotechnic & Histochemistry 18 May 2016, Vol.91(4), pp.277-282
Main Author: Arslan, H
Other Authors: Aktaş, A , Elibol, E , Esener, Obb , Türkmen, AP , Yurt, Kk , Onger, ME , Altunkaynak, Bz , Kaplan, S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Rat
ID: ISSN: 1052-0295 ; E-ISSN: 1473-7760 ; DOI: 10.3109/10520295.2016.1151551
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recordid: informaworld_s10_3109_10520295_2016_1151551
title: Effects of prenatal diclofenac sodium exposure on newborn testis: a histomorphometric study
format: Article
creator:
  • Arslan, H
  • Aktaş, A
  • Elibol, E
  • Esener, Obb
  • Türkmen, AP
  • Yurt, Kk
  • Onger, ME
  • Altunkaynak, Bz
  • Kaplan, S
subjects:
  • Diclofenac Sodium
  • Physical Disector
  • Rat
  • Sertoli Cells
  • Spermatogonia
  • Stereology
  • Testis
  • Engineering
  • Biology
ispartof: Biotechnic & Histochemistry, 18 May 2016, Vol.91(4), pp.277-282
description: Diclofenac sodium (DS) is used primarily to treat fever and to alleviate pain and inflammation. We investigated the effects of DS exposure during gestation on the testes of rat pups to investigate the safety of its use during the prenatal period. Pregnant rats were separated into control, saline, low dose, medium dose and high dose groups. DS was given between weeks 15 and 21 of gestation. Total numbers of spermatogonia and Sertoli cells were counted in the testes of 7-day-old male rats using the physical disector method. By the end of the study, the total number of Sertoli cells was decreased significantly in a dose dependent manner in the medium and high dose groups compared to controls. No significant differences were found in the total number of spermatogonia in the control, saline and low dose DS groups. Medium and high dose DS administration reduced the total number of spermatogonia compared to other groups. We suggest that prenatal administration of DS can cause deleterious effects on the testis development, especially in high doses.
language: eng
source:
identifier: ISSN: 1052-0295 ; E-ISSN: 1473-7760 ; DOI: 10.3109/10520295.2016.1151551
fulltext: fulltext
issn:
  • 1052-0295
  • 10520295
  • 1473-7760
  • 14737760
url: Link


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titleEffects of prenatal diclofenac sodium exposure on newborn testis: a histomorphometric study
creatorArslan, H ; Aktaş, A ; Elibol, E ; Esener, Obb ; Türkmen, AP ; Yurt, Kk ; Onger, ME ; Altunkaynak, Bz ; Kaplan, S
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descriptionDiclofenac sodium (DS) is used primarily to treat fever and to alleviate pain and inflammation. We investigated the effects of DS exposure during gestation on the testes of rat pups to investigate the safety of its use during the prenatal period. Pregnant rats were separated into control, saline, low dose, medium dose and high dose groups. DS was given between weeks 15 and 21 of gestation. Total numbers of spermatogonia and Sertoli cells were counted in the testes of 7-day-old male rats using the physical disector method. By the end of the study, the total number of Sertoli cells was decreased significantly in a dose dependent manner in the medium and high dose groups compared to controls. No significant differences were found in the total number of spermatogonia in the control, saline and low dose DS groups. Medium and high dose DS administration reduced the total number of spermatogonia compared to other groups. We suggest that prenatal administration of DS can cause deleterious effects on the testis development, especially in high doses.
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titleEffects of prenatal diclofenac sodium exposure on newborn testis: a histomorphometric study
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Diclofenac sodium (DS) is used primarily to treat fever and to alleviate pain and inflammation. We investigated the effects of DS exposure during gestation on the testes of rat pups to investigate the safety of its use during the prenatal period. Pregnant rats were separated into control, saline, low dose, medium dose and high dose groups. DS was given between weeks 15 and 21 of gestation. Total numbers of spermatogonia and Sertoli cells were counted in the testes of 7-day-old male rats using the physical disector method. By the end of the study, the total number of Sertoli cells was decreased significantly in a dose dependent manner in the medium and high dose groups compared to controls. No significant differences were found in the total number of spermatogonia in the control, saline and low dose DS groups. Medium and high dose DS administration reduced the total number of spermatogonia compared to other groups. We suggest that prenatal administration of DS can cause deleterious effects on the testis development, especially in high doses.

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abstract

Diclofenac sodium (DS) is used primarily to treat fever and to alleviate pain and inflammation. We investigated the effects of DS exposure during gestation on the testes of rat pups to investigate the safety of its use during the prenatal period. Pregnant rats were separated into control, saline, low dose, medium dose and high dose groups. DS was given between weeks 15 and 21 of gestation. Total numbers of spermatogonia and Sertoli cells were counted in the testes of 7-day-old male rats using the physical disector method. By the end of the study, the total number of Sertoli cells was decreased significantly in a dose dependent manner in the medium and high dose groups compared to controls. No significant differences were found in the total number of spermatogonia in the control, saline and low dose DS groups. Medium and high dose DS administration reduced the total number of spermatogonia compared to other groups. We suggest that prenatal administration of DS can cause deleterious effects on the testis development, especially in high doses.

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doi10.3109/10520295.2016.1151551
urlhttp://www.tandfonline.com/doi/abs/10.3109/10520295.2016.1151551
date2016-05-18