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Development of a new nanovesicle formulation as transdermal carrier: Formulation, physicochemical characterization, permeation studies and anti-inflammatory activity

Context: Ibuprofen is an important NSAID, however, it can cause GI disturbances when given orally, and employment of transdermal route will require permeation enhancer causing skin injury. Objective: Drug-loaded nanovesicles of ceramide-2, cholesterol, palmitic acid, and cholesteryl sulfate (ICVG) w... Full description

Journal Title: Artificial Cells Nanomedicine, and Biotechnology, 01 October 2014, Vol.42(5), pp.323-330
Main Author: Gaur, Praveen Kumar
Other Authors: Mishra, Shikha , Purohit, Suresh , Kumar, Yatendra , Bhandari, Anil
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 2169-1401 ; E-ISSN: 2169-141X ; DOI: 10.3109/21691401.2013.827119
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recordid: informaworld_s10_3109_21691401_2013_827119
title: Development of a new nanovesicle formulation as transdermal carrier: Formulation, physicochemical characterization, permeation studies and anti-inflammatory activity
format: Article
creator:
  • Gaur, Praveen Kumar
  • Mishra, Shikha
  • Purohit, Suresh
  • Kumar, Yatendra
  • Bhandari, Anil
subjects:
  • Anti-Inflammatory
  • Ex Vivo
  • in Vitro
  • Permeation
  • Transdermal
  • Vesicle
  • Engineering
ispartof: Artificial Cells, Nanomedicine, and Biotechnology, 01 October 2014, Vol.42(5), pp.323-330
description: Context: Ibuprofen is an important NSAID, however, it can cause GI disturbances when given orally, and employment of transdermal route will require permeation enhancer causing skin injury. Objective: Drug-loaded nanovesicles of ceramide-2, cholesterol, palmitic acid, and cholesteryl sulfate (ICVG) were formulated and analyzed for physicochemical and permeation properties. Materials and method: Vesicles were formulated using film hydration method and physicochemical parameters, in vitro drug release, and stability were assessed. Further, nanovesicle gels were evaluated against plain gel containing drug (CG) for ex vivo/in vivo drug permeation and anti-inflammatory activity. Results: The developed formulations showed optimal physicochemical profile and ICV-1 gave 97.24% drug release. Drug permeation was between 17.32 and 33.12 μg/cm 2 for ICVG formulations and 0.27 μg/cm 2 for CG. ICVG-1 and CG showed...
language: eng
source:
identifier: ISSN: 2169-1401 ; E-ISSN: 2169-141X ; DOI: 10.3109/21691401.2013.827119
fulltext: fulltext
issn:
  • 2169-1401
  • 21691401
  • 2169-141X
  • 2169141X
url: Link


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titleDevelopment of a new nanovesicle formulation as transdermal carrier: Formulation, physicochemical characterization, permeation studies and anti-inflammatory activity
creatorGaur, Praveen Kumar ; Mishra, Shikha ; Purohit, Suresh ; Kumar, Yatendra ; Bhandari, Anil
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subjectAnti-Inflammatory ; Ex Vivo ; in Vitro ; Permeation ; Transdermal ; Vesicle ; Engineering
descriptionContext: Ibuprofen is an important NSAID, however, it can cause GI disturbances when given orally, and employment of transdermal route will require permeation enhancer causing skin injury. Objective: Drug-loaded nanovesicles of ceramide-2, cholesterol, palmitic acid, and cholesteryl sulfate (ICVG) were formulated and analyzed for physicochemical and permeation properties. Materials and method: Vesicles were formulated using film hydration method and physicochemical parameters, in vitro drug release, and stability were assessed. Further, nanovesicle gels were evaluated against plain gel containing drug (CG) for ex vivo/in vivo drug permeation and anti-inflammatory activity. Results: The developed formulations showed optimal physicochemical profile and ICV-1 gave 97.24% drug release. Drug permeation was between 17.32 and 33.12 μg/cm 2 for ICVG formulations and 0.27 μg/cm 2 for CG. ICVG-1 and CG showed...
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