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Development of ibuprofen nanoliposome for transdermal delivery: Physical characterization, in vitro/in vivo studies, and anti-inflammatory activity

Objective: Ibuprofen is an established non-steroidal anti-inflammatory drug commonly used for general inflammation. However, it causes gastrointestinal troubles when administered orally, thereby decreasing patient compliance. Transdermal application of vesicular formulation of Ibuprofen will provide... Full description

Journal Title: Artificial Cells Nanomedicine, and Biotechnology, 02 January 2016, Vol.44(1), pp.370-375
Main Author: Gaur, Praveen Kumar
Other Authors: Bajpai, Meenakshi , Mishra, Shikha , Verma, Anurag
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 2169-1401 ; E-ISSN: 2169-141X ; DOI: 10.3109/21691401.2014.953631
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recordid: informaworld_s10_3109_21691401_2014_953631
title: Development of ibuprofen nanoliposome for transdermal delivery: Physical characterization, in vitro/in vivo studies, and anti-inflammatory activity
format: Article
creator:
  • Gaur, Praveen Kumar
  • Bajpai, Meenakshi
  • Mishra, Shikha
  • Verma, Anurag
subjects:
  • Delivery
  • Entrapment Efficiency
  • Ibuprofen
  • Permeation
  • Nanoliposome
  • Engineering
ispartof: Artificial Cells, Nanomedicine, and Biotechnology, 02 January 2016, Vol.44(1), pp.370-375
description: Objective: Ibuprofen is an established non-steroidal anti-inflammatory drug commonly used for general inflammation. However, it causes gastrointestinal troubles when administered orally, thereby decreasing patient compliance. Transdermal application of vesicular formulation of Ibuprofen will provide better patient compliance and efficacy. Methods: Six different compositions of lipid constituents have been formulated into nanovesicles using thin-film hydration method and dispersed into gel using Carbopol 934. The formulations were characterized based on physicochemical parameters using photon correlation spectroscopy, transmission electron microscopy, in vitro drug release, ex vivo skin permeation using human skin, and in vivo studies. Results: The formulation, ibuprofen liposomal gel-5 (ILG-5), had nanoliposome of smallest size (159 nm) and polydispersity index (0.331). This formulation showed moderate zeta potential and the highest encapsulation. All the formulations including...
language: eng
source:
identifier: ISSN: 2169-1401 ; E-ISSN: 2169-141X ; DOI: 10.3109/21691401.2014.953631
fulltext: fulltext
issn:
  • 2169-1401
  • 21691401
  • 2169-141X
  • 2169141X
url: Link


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titleDevelopment of ibuprofen nanoliposome for transdermal delivery: Physical characterization, in vitro/in vivo studies, and anti-inflammatory activity
creatorGaur, Praveen Kumar ; Bajpai, Meenakshi ; Mishra, Shikha ; Verma, Anurag
ispartofArtificial Cells, Nanomedicine, and Biotechnology, 02 January 2016, Vol.44(1), pp.370-375
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subjectDelivery ; Entrapment Efficiency ; Ibuprofen ; Permeation ; Nanoliposome ; Engineering
descriptionObjective: Ibuprofen is an established non-steroidal anti-inflammatory drug commonly used for general inflammation. However, it causes gastrointestinal troubles when administered orally, thereby decreasing patient compliance. Transdermal application of vesicular formulation of Ibuprofen will provide better patient compliance and efficacy. Methods: Six different compositions of lipid constituents have been formulated into nanovesicles using thin-film hydration method and dispersed into gel using Carbopol 934. The formulations were characterized based on physicochemical parameters using photon correlation spectroscopy, transmission electron microscopy, in vitro drug release, ex vivo skin permeation using human skin, and in vivo studies. Results: The formulation, ibuprofen liposomal gel-5 (ILG-5), had nanoliposome of smallest size (159 nm) and polydispersity index (0.331). This formulation showed moderate zeta potential and the highest encapsulation. All the formulations including...
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Objective: Ibuprofen is an established non-steroidal anti-inflammatory drug commonly used for general inflammation. However, it causes gastrointestinal troubles when administered orally, thereby decreasing patient compliance. Transdermal application of vesicular formulation of Ibuprofen will provide better patient compliance and efficacy. Methods: Six different compositions of lipid constituents have been formulated into nanovesicles using thin-film hydration method and dispersed into gel using Carbopol 934. The formulations were characterized based on physicochemical parameters using photon correlation spectroscopy, transmission electron microscopy, in vitro drug release, ex vivo skin permeation using human skin, and in vivo studies. Results: The formulation, ibuprofen liposomal gel-5 (ILG-5), had nanoliposome of smallest size (159 nm) and polydispersity index (0.331). This formulation showed moderate zeta potential and the highest encapsulation. All the formulations including...

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Objective: Ibuprofen is an established non-steroidal anti-inflammatory drug commonly used for general inflammation. However, it causes gastrointestinal troubles when administered orally, thereby decreasing patient compliance. Transdermal application of vesicular formulation of Ibuprofen will provide better patient compliance and efficacy. Methods: Six different compositions of lipid constituents have been formulated into nanovesicles using thin-film hydration method and dispersed into gel using Carbopol 934. The formulations were characterized based on physicochemical parameters using photon correlation spectroscopy, transmission electron microscopy, in vitro drug release, ex vivo skin permeation using human skin, and in vivo studies. Results: The formulation, ibuprofen liposomal gel-5 (ILG-5), had nanoliposome of smallest size (159 nm) and polydispersity index (0.331). This formulation showed moderate zeta potential and the highest encapsulation. All the formulations including...

pubTaylor & Francis
doi10.3109/21691401.2014.953631
urlhttp://www.tandfonline.com/doi/abs/10.3109/21691401.2014.953631
lad01Artificial Cells, Nanomedicine, and Biotechnology
date2016-01-02