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Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis

Chromosome instability (CIN) is found in 85% of colorectal cancers. Defects in mitotic processes are implicated in high CIN and may be critical events in colorectal tumorigenesis. Shugoshin-1 (SGO1) aids in the maintenance of chromosome cohesion and prevents premature chromosome separation...

Journal Title: Cell Cycle 01 February 2012, Vol.11(3), pp.479-488
Main Author: Yamada, Hiroshi Y
Other Authors: Yao, Yixin , Wang, Xiaoxing , Zhang, Yuting , Huang, Ying , Dai, Wei , Rao, Chinthalapally V
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1538-4101 ; E-ISSN: 1551-4005 ; DOI: 10.4161/cc.11.3.18994
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recordid: informaworld_s10_4161_cc_11_3_18994
title: Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis
format: Article
creator:
  • Yamada, Hiroshi Y
  • Yao, Yixin
  • Wang, Xiaoxing
  • Zhang, Yuting
  • Huang, Ying
  • Dai, Wei
  • Rao, Chinthalapally V
subjects:
  • Biology
ispartof: Cell Cycle, 01 February 2012, Vol.11(3), pp.479-488
description: Chromosome instability (CIN) is found in 85% of colorectal cancers. Defects in mitotic processes are implicated in high CIN and may be critical events in colorectal tumorigenesis. Shugoshin-1 (SGO1) aids in the maintenance of chromosome cohesion and prevents premature chromosome separation...
language: eng
source:
identifier: ISSN: 1538-4101 ; E-ISSN: 1551-4005 ; DOI: 10.4161/cc.11.3.18994
fulltext: fulltext
issn:
  • 1538-4101
  • 15384101
  • 1551-4005
  • 15514005
url: Link


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titleHaploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis
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descriptionChromosome instability (CIN) is found in 85% of colorectal cancers. Defects in mitotic processes are implicated in high CIN and may be critical events in colorectal tumorigenesis. Shugoshin-1 (SGO1) aids in the maintenance of chromosome cohesion and prevents premature chromosome separation...
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titleHaploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis
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Chromosome instability (CIN) is found in 85% of colorectal cancers. Defects in mitotic processes are implicated in high CIN and may be critical events in colorectal tumorigenesis. Shugoshin-1 (SGO1) aids in the maintenance of chromosome cohesion and prevents premature chromosome separation...

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Chromosome instability (CIN) is found in 85% of colorectal cancers. Defects in mitotic processes are implicated in high CIN and may be critical events in colorectal tumorigenesis. Shugoshin-1 (SGO1) aids in the maintenance of chromosome cohesion and prevents premature chromosome separation...

pubTaylor & Francis
doi10.4161/cc.11.3.18994
urlhttp://www.tandfonline.com/doi/abs/10.4161/cc.11.3.18994
lad01Cell Cycle
date2012-02-01