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Dietary diversity no longer offsets the mortality risk of hyperhomocysteinaemia in older adults with diabetes: A prospective cohort study

Background and Objective: The increased mortality risk of hyperhomocysteinaemia in diabetes may be mitigated by dietary quality. Methods and Study Design: The Nutrition and Health Survey in Taiwan of 1999-2000 for elders formed this prospective cohort. Baseline health status, diet and anthropometry... Full description

Journal Title: Asia Pacific Journal of Clinical Nutrition Vol. 25, No. 2, 2016: 414-423
Main Author: Wahlqvist, Mark L
Other Authors: Xiu, Lili , Lee, Meei-Shyuan , Chen, Rosalind Chia-Yu , Chen, Kuan-Ju , Li, Duo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0964-7058
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recordid: informit_apaft104622577840390
title: Dietary diversity no longer offsets the mortality risk of hyperhomocysteinaemia in older adults with diabetes: A prospective cohort study
format: Article
creator:
  • Wahlqvist, Mark L
  • Xiu, Lili
  • Lee, Meei-Shyuan
  • Chen, Rosalind Chia-Yu
  • Chen, Kuan-Ju
  • Li, Duo
subjects:
  • Homocysteine
  • Diabetes--Mortality
  • Diabetes--Diet Therapy
  • Diabetes--Complications
  • Diet Therapy--Quality Control
ispartof: Asia Pacific Journal of Clinical Nutrition, Vol. 25, No. 2, 2016: 414-423
description: Background and Objective: The increased mortality risk of hyperhomocysteinaemia in diabetes may be mitigated by dietary quality. Methods and Study Design: The Nutrition and Health Survey in Taiwan of 1999-2000 for elders formed this prospective cohort. Baseline health status, diet and anthropometry were documented and plasma homocysteine and biomarkers for B vitamins measured. Participants without diabetes (n=985) were referent for those who had diabetes or developed diabetes until 2006 (n=427). The effect of homocysteine on mortality risk during 1999-2008 was evaluated. Results: Men, smokers and those with poorer physical function had higher homocysteine, but less so with diabetes. Diabetes incidence was unrelated to homocysteine. In hyperhomocysteinaemia (=15 vs 4) and lower homocysteine (
language: eng
source:
identifier: ISSN: 0964-7058
fulltext: fulltext
issn:
  • 0964-7058
  • 09647058
url: Link


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titleDietary diversity no longer offsets the mortality risk of hyperhomocysteinaemia in older adults with diabetes: A prospective cohort study
creatorWahlqvist, Mark L ; Xiu, Lili ; Lee, Meei-Shyuan ; Chen, Rosalind Chia-Yu ; Chen, Kuan-Ju ; Li, Duo
ispartofAsia Pacific Journal of Clinical Nutrition, Vol. 25, No. 2, 2016: 414-423
identifierISSN: 0964-7058
subjectHomocysteine ; Diabetes--Mortality ; Diabetes--Diet Therapy ; Diabetes--Complications ; Diet Therapy--Quality Control
descriptionBackground and Objective: The increased mortality risk of hyperhomocysteinaemia in diabetes may be mitigated by dietary quality. Methods and Study Design: The Nutrition and Health Survey in Taiwan of 1999-2000 for elders formed this prospective cohort. Baseline health status, diet and anthropometry were documented and plasma homocysteine and biomarkers for B vitamins measured. Participants without diabetes (n=985) were referent for those who had diabetes or developed diabetes until 2006 (n=427). The effect of homocysteine on mortality risk during 1999-2008 was evaluated. Results: Men, smokers and those with poorer physical function had higher homocysteine, but less so with diabetes. Diabetes incidence was unrelated to homocysteine. In hyperhomocysteinaemia (=15 vs 4) and lower homocysteine (<15) was referent, the HR was 1.80 (1.27-2.54) with significant interaction (p=0.008); by contrast, there was no joint effect with diabetes. The contribution of DDS to mortality mitigation in hyperhomocysteinaemia could not be explained by B group vitamins, even though plasma folate was low in hyperhomocysteinaemic participants. With hyperhomocysteinaemia, heart failure was a major cause of death. Conclusions: In non-diabetic hyperhomocysteinaemia, a more diverse diet increases survival prospects independent of B group vitamins, but not in hyperhomocysteinaemic diabetes where the cardiomyopathy may be less responsive.
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titleDietary diversity no longer offsets the mortality risk of hyperhomocysteinaemia in older adults with diabetes: A prospective cohort study
descriptionBackground and Objective: The increased mortality risk of hyperhomocysteinaemia in diabetes may be mitigated by dietary quality. Methods and Study Design: The Nutrition and Health Survey in Taiwan of 1999-2000 for elders formed this prospective cohort. Baseline health status, diet and anthropometry were documented and plasma homocysteine and biomarkers for B vitamins measured. Participants without diabetes (n=985) were referent for those who had diabetes or developed diabetes until 2006 (n=427). The effect of homocysteine on mortality risk during 1999-2008 was evaluated. Results: Men, smokers and those with poorer physical function had higher homocysteine, but less so with diabetes. Diabetes incidence was unrelated to homocysteine. In hyperhomocysteinaemia (=15 vs 4) and lower homocysteine (<15) was referent, the HR was 1.80 (1.27-2.54) with significant interaction (p=0.008); by contrast, there was no joint effect with diabetes. The contribution of DDS to mortality mitigation in hyperhomocysteinaemia could not be explained by B group vitamins, even though plasma folate was low in hyperhomocysteinaemic participants. With hyperhomocysteinaemia, heart failure was a major cause of death. Conclusions: In non-diabetic hyperhomocysteinaemia, a more diverse diet increases survival prospects independent of B group vitamins, but not in hyperhomocysteinaemic diabetes where the cardiomyopathy may be less responsive.
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abstractBackground and Objective: The increased mortality risk of hyperhomocysteinaemia in diabetes may be mitigated by dietary quality. Methods and Study Design: The Nutrition and Health Survey in Taiwan of 1999-2000 for elders formed this prospective cohort. Baseline health status, diet and anthropometry were documented and plasma homocysteine and biomarkers for B vitamins measured. Participants without diabetes (n=985) were referent for those who had diabetes or developed diabetes until 2006 (n=427). The effect of homocysteine on mortality risk during 1999-2008 was evaluated. Results: Men, smokers and those with poorer physical function had higher homocysteine, but less so with diabetes. Diabetes incidence was unrelated to homocysteine. In hyperhomocysteinaemia (=15 vs 4) and lower homocysteine (<15) was referent, the HR was 1.80 (1.27-2.54) with significant interaction (p=0.008); by contrast, there was no joint effect with diabetes. The contribution of DDS to mortality mitigation in hyperhomocysteinaemia could not be explained by B group vitamins, even though plasma folate was low in hyperhomocysteinaemic participants. With hyperhomocysteinaemia, heart failure was a major cause of death. Conclusions: In non-diabetic hyperhomocysteinaemia, a more diverse diet increases survival prospects independent of B group vitamins, but not in hyperhomocysteinaemic diabetes where the cardiomyopathy may be less responsive.
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