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Assignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22

Linkage analysis of ten Utah kindreds and one Texas kindred with multiple cases of cutaneous malignant melanoma (CMM) provided evidence that a locus for familial melanoma susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside in a candidate region on chromosome 9p2... Full description

Journal Title: Science 13 November 1992, Vol.258(5085), pp.1148-1152
Main Author: Cannon-Albright, Lisa A.
Other Authors: Goldgar, David E. , Meyer, Laurence J. , Lewis, Cathryn M. , Anderson, David E. , Fountain, Jane W. , Hegi, Monika E. , Wiseman, Roger W. , Petty, Elizabeth M. , Bale, Allen E. , Olopade, Olufunmilayo I. , Diaz, Manuel O. , Kwiatkowski, David J. , Piepkorn, Michael W. , Zone, John J. , Skolnick, Mark H.
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 00368075 ; E-ISSN: 10959203
Link: https://www.jstor.org/stable/2880521
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title: Assignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22
format: Article
creator:
  • Cannon-Albright, Lisa A.
  • Goldgar, David E.
  • Meyer, Laurence J.
  • Lewis, Cathryn M.
  • Anderson, David E.
  • Fountain, Jane W.
  • Hegi, Monika E.
  • Wiseman, Roger W.
  • Petty, Elizabeth M.
  • Bale, Allen E.
  • Olopade, Olufunmilayo I.
  • Diaz, Manuel O.
  • Kwiatkowski, David J.
  • Piepkorn, Michael W.
  • Zone, John J.
  • Skolnick, Mark H.
subjects:
  • Health sciences -- Medical conditions -- Diseases
  • Biological sciences -- Biology -- Genetics
  • Biological sciences -- Biology -- Cytology
  • Biological sciences -- Biology -- Genetics
  • Biological sciences -- Biology -- Genetics
  • Health sciences -- Medical conditions -- Diseases
  • Biological sciences -- Biology -- Genetics
  • Biological sciences -- Biology -- Genetics
  • Biological sciences -- Biology -- Genetics
  • Biological sciences -- Biology -- Genetics
ispartof: Science, 13 November 1992, Vol.258(5085), pp.1148-1152
description: Linkage analysis of ten Utah kindreds and one Texas kindred with multiple cases of cutaneous malignant melanoma (CMM) provided evidence that a locus for familial melanoma susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside in a candidate region on chromosome 9p21, previously implicated by the presence of homozygous deletions in melanoma tumors and by the presence of a germline deletion in an individual with eight independent melanomas. Multipoint linkage analysis was performed between the familial melanoma susceptibility locus (MLM) and two short tandem repeat markers, D9S126 and the interferon-α (IFNA) gene, which reside in the region of somatic loss in melanoma tumors. An analysis incorporating a partially penetrant dominant melanoma susceptibility locus places MLM near IFNA and D9S126 with a maximum location score of 12.71. Therefore, the region frequently deleted in melanoma tumors on 9p21 presumably contains a locus that plays a critical role in predisposition to familial melanoma.
language: eng
source:
identifier: ISSN: 00368075 ; E-ISSN: 10959203
fulltext: fulltext
issn:
  • 0036-8075
  • 00368075
  • 1095-9203
  • 10959203
url: Link


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titleAssignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22
creatorCannon-Albright, Lisa A. ; Goldgar, David E. ; Meyer, Laurence J. ; Lewis, Cathryn M. ; Anderson, David E. ; Fountain, Jane W. ; Hegi, Monika E. ; Wiseman, Roger W. ; Petty, Elizabeth M. ; Bale, Allen E. ; Olopade, Olufunmilayo I. ; Diaz, Manuel O. ; Kwiatkowski, David J. ; Piepkorn, Michael W. ; Zone, John J. ; Skolnick, Mark H.
ispartofScience, 13 November 1992, Vol.258(5085), pp.1148-1152
identifierISSN: 00368075 ; E-ISSN: 10959203
subjectHealth sciences -- Medical conditions -- Diseases ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Cytology ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Genetics ; Health sciences -- Medical conditions -- Diseases ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Genetics
descriptionLinkage analysis of ten Utah kindreds and one Texas kindred with multiple cases of cutaneous malignant melanoma (CMM) provided evidence that a locus for familial melanoma susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside in a candidate region on chromosome 9p21, previously implicated by the presence of homozygous deletions in melanoma tumors and by the presence of a germline deletion in an individual with eight independent melanomas. Multipoint linkage analysis was performed between the familial melanoma susceptibility locus (MLM) and two short tandem repeat markers, D9S126 and the interferon-α (IFNA) gene, which reside in the region of somatic loss in melanoma tumors. An analysis incorporating a partially penetrant dominant melanoma susceptibility locus places MLM near IFNA and D9S126 with a maximum location score of 12.71. Therefore, the region frequently deleted in melanoma tumors on 9p21 presumably contains a locus that plays a critical role in predisposition to familial melanoma.
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titleAssignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22
descriptionLinkage analysis of ten Utah kindreds and one Texas kindred with multiple cases of cutaneous malignant melanoma (CMM) provided evidence that a locus for familial melanoma susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside in a candidate region on chromosome 9p21, previously implicated by the presence of homozygous deletions in melanoma tumors and by the presence of a germline deletion in an individual with eight independent melanomas. Multipoint linkage analysis was performed between the familial melanoma susceptibility locus (MLM) and two short tandem repeat markers, D9S126 and the interferon-α (IFNA) gene, which reside in the region of somatic loss in melanoma tumors. An analysis incorporating a partially penetrant dominant melanoma susceptibility locus places MLM near IFNA and D9S126 with a maximum location score of 12.71. Therefore, the region frequently deleted in melanoma tumors on 9p21 presumably contains a locus that plays a critical role in predisposition to familial melanoma.
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titleAssignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22
authorCannon-Albright, Lisa A. ; Goldgar, David E. ; Meyer, Laurence J. ; Lewis, Cathryn M. ; Anderson, David E. ; Fountain, Jane W. ; Hegi, Monika E. ; Wiseman, Roger W. ; Petty, Elizabeth M. ; Bale, Allen E. ; Olopade, Olufunmilayo I. ; Diaz, Manuel O. ; Kwiatkowski, David J. ; Piepkorn, Michael W. ; Zone, John J. ; Skolnick, Mark H.
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atitleAssignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22
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abstractLinkage analysis of ten Utah kindreds and one Texas kindred with multiple cases of cutaneous malignant melanoma (CMM) provided evidence that a locus for familial melanoma susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside in a candidate region on chromosome 9p21, previously implicated by the presence of homozygous deletions in melanoma tumors and by the presence of a germline deletion in an individual with eight independent melanomas. Multipoint linkage analysis was performed between the familial melanoma susceptibility locus (MLM) and two short tandem repeat markers, D9S126 and the interferon-α (IFNA) gene, which reside in the region of somatic loss in melanoma tumors. An analysis incorporating a partially penetrant dominant melanoma susceptibility locus places MLM near IFNA and D9S126 with a maximum location score of 12.71. Therefore, the region frequently deleted in melanoma tumors on 9p21 presumably contains a locus that plays a critical role in predisposition to familial melanoma.
pubAmerican Society for the Advancement of Science
doi10.1126/science.1439824
date1992-11-13