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Organic synthesis toward small-molecule probes and drugs

"Organic synthesis" is a compound-creating activity often focused on biologically active small molecules. This special issue of PNAS explores innovations and trends in the field that are enabling the synthesis of new types of small-molecule probes and drugs. This perspective article frames the resea... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 26 April 2011, Vol.108(17), pp.6699-6702
Main Author: Schreiber, Stuart L.
Other Authors: Halpern, Jack
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00278424
Link: https://www.jstor.org/stable/41242065
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recordid: jstor_archive_2341242065
title: Organic synthesis toward small-molecule probes and drugs
format: Article
creator:
  • Schreiber, Stuart L.
  • Halpern, Jack
subjects:
  • Physical sciences -- Physics -- Microphysics
  • Physical sciences -- Chemistry -- Chemical reactions
  • Health sciences -- Medical sciences -- Medical research
  • Biological sciences -- Biology -- Genetics
  • Health sciences -- Medical sciences -- Pharmaceutics
  • Physical sciences -- Chemistry -- Chemical compounds
  • Physical sciences -- Chemistry -- Cytology
  • Biological sciences -- Biology -- Zoology
  • Biological sciences -- Biology -- Diseases
  • Health sciences -- Medical conditions -- Diseases
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 26 April 2011, Vol.108(17), pp.6699-6702
description: "Organic synthesis" is a compound-creating activity often focused on biologically active small molecules. This special issue of PNAS explores innovations and trends in the field that are enabling the synthesis of new types of small-molecule probes and drugs. This perspective article frames the research described in the special issue but also explores how these modern capabilities can both foster a new and more extensive view of basic research in the academy and promote the linkage of life-science research to the discovery of novel types of small-molecule therapeutics [Schreiber SL (2009) Chem Bio Chem 10:26-29]. This new view of basic research aims to bridge the chasm between basic scientific discoveries in life sciences and new drugs that treat the root cause of human disease—recently referred to as the "valley of death" for drug discovery. This perspective article describes new roles that modern organic chemistry will need to play in overcoming this challenge.
language: eng
source:
identifier: ISSN: 00278424
fulltext: fulltext
issn:
  • 0027-8424
  • 00278424
url: Link


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titleOrganic synthesis toward small-molecule probes and drugs
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ispartofProceedings of the National Academy of Sciences of the United States of America, 26 April 2011, Vol.108(17), pp.6699-6702
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subjectPhysical sciences -- Physics -- Microphysics ; Physical sciences -- Chemistry -- Chemical reactions ; Health sciences -- Medical sciences -- Medical research ; Biological sciences -- Biology -- Genetics ; Health sciences -- Medical sciences -- Pharmaceutics ; Physical sciences -- Chemistry -- Chemical compounds ; Physical sciences -- Chemistry -- Cytology ; Biological sciences -- Biology -- Zoology ; Biological sciences -- Biology -- Diseases ; Health sciences -- Medical conditions -- Diseases
description"Organic synthesis" is a compound-creating activity often focused on biologically active small molecules. This special issue of PNAS explores innovations and trends in the field that are enabling the synthesis of new types of small-molecule probes and drugs. This perspective article frames the research described in the special issue but also explores how these modern capabilities can both foster a new and more extensive view of basic research in the academy and promote the linkage of life-science research to the discovery of novel types of small-molecule therapeutics [Schreiber SL (2009) Chem Bio Chem 10:26-29]. This new view of basic research aims to bridge the chasm between basic scientific discoveries in life sciences and new drugs that treat the root cause of human disease—recently referred to as the "valley of death" for drug discovery. This perspective article describes new roles that modern organic chemistry will need to play in overcoming this challenge.
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abstract"Organic synthesis" is a compound-creating activity often focused on biologically active small molecules. This special issue of PNAS explores innovations and trends in the field that are enabling the synthesis of new types of small-molecule probes and drugs. This perspective article frames the research described in the special issue but also explores how these modern capabilities can both foster a new and more extensive view of basic research in the academy and promote the linkage of life-science research to the discovery of novel types of small-molecule therapeutics [Schreiber SL (2009) Chem Bio Chem 10:26-29]. This new view of basic research aims to bridge the chasm between basic scientific discoveries in life sciences and new drugs that treat the root cause of human disease—recently referred to as the "valley of death" for drug discovery. This perspective article describes new roles that modern organic chemistry will need to play in overcoming this challenge.
pubNational Academy of Sciences
doi10.1073/pnas.1103205108
eissn10916490
date2011-04-26