schliessen

Filtern

 

Bibliotheken

A genome-wide association search for type 2 diabetes genes in African Americans

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide A... Full description

Journal Title: Palmer Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; +380 more... (2012) A genome-wide association search for type 2 diabetes genes in African Americans. PloS one, 7 (1). e29202
Main Author: Palmer, Nicholette D
Other Authors: Mcdonough, Caitrin W , Hicks, Pamela J , Roh, Bong H , Wing, Maria R , An, S Sandy , Hester, Jessica M , Cooke, Jessica N , Bostrom, Meredith A , Rudock, Megan E , Talbert, Matthew E , Lewis, Joshua P , Ferrara, Assiamira , Lu, Lingyi , Ziegler, Julie T , Sale, Michele M , Divers, Jasmin , Shriner, Daniel , Adeyemo, Adebowale , Rotimi, Charles N , Ng, Maggie C Y , Langefeld, Carl D , Freedman, Barry I , Bowden, Donald W , Voight, Benjamin F , Scott, Laura J , Steinthorsdottir, Valgerdur , Morris, Andrew P , Dina, Christian , Welch, Ryan P , Zeggini, Eleftheria , Huth, Cornelia , Aulchenko, Yurii S , Thorleifsson, Gudmar , Mcculloch, Laura J , Ferreira, Teresa , Grallert, Harald , Amin, Najaf , Wu, Guanming , Willer, Cristen J , Raychaudhuri, Soumya , Mccarroll, Steve A , Langenberg, Claudia , Hofmann, Oliver M , Dupuis, Josée , Qi, Lu , Segrè, Ayellet V , Van Hoek, Mandy , Navarro, Pau , Ardlie, Kristin , Balkau, Beverley , Benediktsson, Rafn , Bennett, Amanda J , Blagieva, Roza , Boerwinkle, Eric , Bonnycastle, Lori L , Boström, Kristina Bengtsson , Bravenboer, Bert , Bumpstead, Suzannah , Burtt, Noël P , Charpentier, Guillaume , Chines, Peter S , Cornelis, Marilyn , Couper, David J , Crawford, Gabe , Doney, Alex S F , Elliott, Katherine S , Elliott, Amanda L , Erdos, Michael R , Fox, Caroline S , Franklin, Christopher S , Ganser, Martha , Gieger, Christian , Grarup, Niels , Green, Todd , Griffin, Simon , Groves, Christopher J , Guiducci, Candace , Hadjadj, Samy , Hassanali, Neelam , Herder, Christian , Isomaa, Bo , Jackson, Anne U , Johnson, Paul R V , Jørgensen, Torben , Kao, Wen H L , Klopp, Norman , Kong, Augustine , Kraft, Peter , Kuusisto, Johanna , Lauritzen, Torsten , Li, Man , Lieverse, Aloysius , Lindgren, Cecilia M , Lyssenko, Valeriya , Marre, Michel , Meitinger, Thomas , Midthjell, Kristian , Morken, Mario A , Narisu, Narisu , Nilsson, Peter , Owen, Katharine R , Payne, Felicity , Perry, John R B , Petersen, Ann - Kristin , Platou, Carl , Proença, Christine , Prokopenko, Inga , Rathmann, Wolfgang , Rayner, N William , Robertson, Neil R , Rocheleau, Ghislain , Roden, Michael , Sampson, Michael J , Saxena, Richa , Shields, Beverley M , Shrader, Peter , Sigurdsson, Gunnar , Sparsø, Thomas , Strassburger, Klaus , Stringham, Heather M , Sun, Qi , Swift, Amy J , Thorand, Barbara , Tichet, Jean , Tuomi, Tiinamaija , Van Dam, Rob M , Van Haeften, Timon W , Van Herpt, Thijs , Van Vliet - Ostaptchouk, Jana V , Walters, G Bragi , Weedon, Michael N , Wijmenga, Cisca , Witteman, Jacqueline , Bergman, Richard N , Cauchi, Stephane , Collins, Francis S , Gloyn, Anna L , Gyllensten, Ulf , Hansen, Torben , Hide, Winston A , Hitman, Graham A , Hofman, Albert , Hunter, David J , Hveem, Kristian , Laakso, Markku , Mohlke, Karen L , Morris, Andrew D , Palmer, Colin N A , Pramstaller, Peter P , Rudan, Igor , Sijbrands, Eric , Stein, Lincoln D , Tuomilehto, Jaakko , Uitterlinden, Andre , Walker, Mark , Wareham, Nicholas J , Watanabe, Richard M , Abecasis, Goncalo R , Boehm, Bernhard O , Campbell, Harry , Daly, Mark J , Hattersley, Andrew T , Hu, Frank B , Meigs, James B , Pankow, James S , Pedersen, Oluf , Wichmann, H - Erich , Barroso, Inês , Florez, Jose C , Frayling, Timothy M , Groop, Leif , Sladek, Rob , Thorsteinsdottir, Unnur , Wilson, James F , Illig, Thomas , Froguel, Philippe , Van Duijn, Cornelia M , Stefansson, Kari , Altshuler, David , Boehnke, Michael , Mccarthy, Mark I , Soranzo, Nicole , Wheeler, Eleanor , Glazer, Nicole L , Bouatia - Naji, Nabila , Mägi, Reedik , Randall, Joshua , Johnson, Toby , Elliott, Paul , Rybin, Denis , Henneman, Peter , Dehghan, Abbas , Hottenga, Jouke Jan , Song, Kijoung , Goel, Anuj , Egan, Josephine M , Lajunen, Taina , Doney, Alex , Kanoni, Stavroula , Cavalcanti - Proença, Christine , Kumari, Meena , Timpson, Nicholas J , Zabena, Carina , Ingelsson, Erik , An, Ping , O'connell, Jeffrey , Luan, Jian'an , Elliott, Amanda , Mccarroll, Steven A , Roccasecca, Rosa Maria , Pattou, François , Sethupathy, Praveen , Ariyurek, Yavuz , Barter, Philip , Beilby, John P , Ben - Shlomo, Yoav , Bergmann, Sven , Bochud, Murielle , Bonnefond, Amélie , Borch - Johnsen, Knut , Böttcher, Yvonne , Brunner, Eric , Bumpstead, Suzannah J , Chen, Yii - Der Ida , Chines, Peter , Clarke, Robert , Coin, Lachlan J M , Cooper, Matthew N , Crisponi, Laura , Day, Ian N M , De Geus, Eco J C , Delplanque, Jerome , Fedson, Annette C , Fischer - Rosinsky, Antje , Forouhi, Nita G , Frants, Rune , Franzosi, Maria Grazia , Galan, Pilar , Goodarzi, Mark O , Graessler, Jürgen , Grundy, Scott , Gwilliam, Rhian , Hallmans, Göran , Hammond, Naomi , Han, Xijing , Hartikainen, Anna - Liisa , Hayward, Caroline , Heath, Simon C , Hercberg, Serge , Hicks, Andrew A , Hillman, David R , Hingorani, Aroon D , Hui, Jennie , Hung, Joe , Jula, Antti , Kaakinen, Marika , Kaprio, Jaakko , Kesaniemi, Y Antero , Kivimaki, Mika , Knight, Beatrice , Koskinen, Seppo , Kovacs, Peter , Kyvik, Kirsten Ohm , Lathrop, G Mark , Lawlor, Debbie A , Le Bacquer, Olivier , Lecoeur, Cécile , Li, Yun , Mahley, Robert , Mangino, Massimo , Manning, Alisa K , Martínez - Larrad, María Teresa , Mcateer, Jarred B , Mcpherson, Ruth , Meisinger, Christa , Melzer, David , Meyre, David , Mitchell, Braxton D , Mukherjee, Sutapa , Naitza, Silvia , Neville, Matthew J , Oostra, Ben A , Orrù, Marco , Pakyz, Ruth , Paolisso, Giuseppe , Pattaro, Cristian , Pearson, Daniel , Peden, John F , Pedersen, Nancy L , Perola, Markus , Pfeiffer, Andreas F H , Pichler, Irene , Polasek, Ozren , Posthuma, Danielle , Potter, Simon C , Pouta, Anneli , Province, Michael A , Psaty, Bruce M , Rayner, Nigel W , Rice, Kenneth , Ripatti, Samuli , Rivadeneira, Fernando , Rolandsson, Olov , Sandbaek, Annelli , Sandhu, Manjinder , Sanna, Serena , Sayer, Avan Aihie , Scheet, Paul , Seedorf, Udo , Sharp, Stephen J , Shields, Beverley , Sijbrands, Eric J G , Silveira, Angela , Simpson, Laila , Singleton, Andrew , Smith, Nicholas L , Sovio, Ulla , Swift, Amy , Syddall, Holly , Syvänen, Ann - Christine , Tanaka, Toshiko , Tönjes, Anke , Uitterlinden, André G , Van Dijk, Ko Willems , Varma, Dhiraj , Visvikis - Siest, Sophie , Vitart, Veronique , Vogelzangs, Nicole , Waeber, Gérard , Wagner, Peter J , Walley, Andrew , Ward, Kim L , Watkins, Hugh , Wild, Sarah H , Willemsen, Gonneke , Witteman, Jaqueline C M , Yarnell, John W G , Zelenika, Diana , Zethelius, Björn , Zhai, Guangju , Zhao, Jing Hua , Zillikens, M Carola , Borecki, Ingrid B , Loos, Ruth J F , Meneton, Pierre , Magnusson, Patrik K E , Nathan, David M , Williams, Gordon H , Silander, Kaisa , Salomaa, Veikko , Smith, George Davey , Bornstein, Stefan R , Schwarz, Peter , Spranger, Joachim , Karpe, Fredrik , Shuldiner, Alan R , Cooper, Cyrus , Dedoussis, George V , Serrano - Ríos, Manuel , Lind, Lars , Palmer, Lyle J , Franks, Paul W , Ebrahim, Shah , Marmot, Michael , Kao, W H Linda , Pramstaller, Peter Paul , Wright, Alan F , Stumvoll, Michael , Hamsten, Anders , Buchanan, Thomas A , Valle, Timo T , Rotter, Jerome I , Siscovick, David S , Penninx, Brenda W J H , Boomsma, Dorret I , Deloukas, Panos , Spector, Timothy D , Ferrucci, Luigi , Cao, Antonio , Scuteri, Angelo , Schlessinger, David , Uda, Manuela , Ruokonen, Aimo , Jarvelin, Marjo - Riitta , Waterworth, Dawn M , Vollenweider, Peter , Peltonen, Leena , Mooser, Vincent , Sladek, Robert
Format: Electronic Article Electronic Article
Language:
Quelle: London School of Hygiene and Tropical Medicine
ID: ISSN: 1932-6203
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: lshtm20693
title: A genome-wide association search for type 2 diabetes genes in African Americans
format: Article
creator:
  • Palmer, Nicholette D
  • Mcdonough, Caitrin W
  • Hicks, Pamela J
  • Roh, Bong H
  • Wing, Maria R
  • An, S Sandy
  • Hester, Jessica M
  • Cooke, Jessica N
  • Bostrom, Meredith A
  • Rudock, Megan E
  • Talbert, Matthew E
  • Lewis, Joshua P
  • Ferrara, Assiamira
  • Lu, Lingyi
  • Ziegler, Julie T
  • Sale, Michele M
  • Divers, Jasmin
  • Shriner, Daniel
  • Adeyemo, Adebowale
  • Rotimi, Charles N
  • Ng, Maggie C Y
  • Langefeld, Carl D
  • Freedman, Barry I
  • Bowden, Donald W
  • Voight, Benjamin F
  • Scott, Laura J
  • Steinthorsdottir, Valgerdur
  • Morris, Andrew P
  • Dina, Christian
  • Welch, Ryan P
  • Zeggini, Eleftheria
  • Huth, Cornelia
  • Aulchenko, Yurii S
  • Thorleifsson, Gudmar
  • Mcculloch, Laura J
  • Ferreira, Teresa
  • Grallert, Harald
  • Amin, Najaf
  • Wu, Guanming
  • Willer, Cristen J
  • Raychaudhuri, Soumya
  • Mccarroll, Steve A
  • Langenberg, Claudia
  • Hofmann, Oliver M
  • Dupuis, Josée
  • Qi, Lu
  • Segrè, Ayellet V
  • Van Hoek, Mandy
  • Navarro, Pau
  • Ardlie, Kristin
  • Balkau, Beverley
  • Benediktsson, Rafn
  • Bennett, Amanda J
  • Blagieva, Roza
  • Boerwinkle, Eric
  • Bonnycastle, Lori L
  • Boström, Kristina Bengtsson
  • Bravenboer, Bert
  • Bumpstead, Suzannah
  • Burtt, Noël P
  • Charpentier, Guillaume
  • Chines, Peter S
  • Cornelis, Marilyn
  • Couper, David J
  • Crawford, Gabe
  • Doney, Alex S F
  • Elliott, Katherine S
  • Elliott, Amanda L
  • Erdos, Michael R
  • Fox, Caroline S
  • Franklin, Christopher S
  • Ganser, Martha
  • Gieger, Christian
  • Grarup, Niels
  • Green, Todd
  • Griffin, Simon
  • Groves, Christopher J
  • Guiducci, Candace
  • Hadjadj, Samy
  • Hassanali, Neelam
  • Herder, Christian
  • Isomaa, Bo
  • Jackson, Anne U
  • Johnson, Paul R V
  • Jørgensen, Torben
  • Kao, Wen H L
  • Klopp, Norman
  • Kong, Augustine
  • Kraft, Peter
  • Kuusisto, Johanna
  • Lauritzen, Torsten
  • Li, Man
  • Lieverse, Aloysius
  • Lindgren, Cecilia M
  • Lyssenko, Valeriya
  • Marre, Michel
  • Meitinger, Thomas
  • Midthjell, Kristian
  • Morken, Mario A
  • Narisu, Narisu
  • Nilsson, Peter
  • Owen, Katharine R
  • Payne, Felicity
  • Perry, John R B
  • Petersen, Ann - Kristin
  • Platou, Carl
  • Proença, Christine
  • Prokopenko, Inga
  • Rathmann, Wolfgang
  • Rayner, N William
  • Robertson, Neil R
  • Rocheleau, Ghislain
  • Roden, Michael
  • Sampson, Michael J
  • Saxena, Richa
  • Shields, Beverley M
  • Shrader, Peter
  • Sigurdsson, Gunnar
  • Sparsø, Thomas
  • Strassburger, Klaus
  • Stringham, Heather M
  • Sun, Qi
  • Swift, Amy J
  • Thorand, Barbara
  • Tichet, Jean
  • Tuomi, Tiinamaija
  • Van Dam, Rob M
  • Van Haeften, Timon W
  • Van Herpt, Thijs
  • Van Vliet - Ostaptchouk, Jana V
  • Walters, G Bragi
  • Weedon, Michael N
  • Wijmenga, Cisca
  • Witteman, Jacqueline
  • Bergman, Richard N
  • Cauchi, Stephane
  • Collins, Francis S
  • Gloyn, Anna L
  • Gyllensten, Ulf
  • Hansen, Torben
  • Hide, Winston A
  • Hitman, Graham A
  • Hofman, Albert
  • Hunter, David J
  • Hveem, Kristian
  • Laakso, Markku
  • Mohlke, Karen L
  • Morris, Andrew D
  • Palmer, Colin N A
  • Pramstaller, Peter P
  • Rudan, Igor
  • Sijbrands, Eric
  • Stein, Lincoln D
  • Tuomilehto, Jaakko
  • Uitterlinden, Andre
  • Walker, Mark
  • Wareham, Nicholas J
  • Watanabe, Richard M
  • Abecasis, Goncalo R
  • Boehm, Bernhard O
  • Campbell, Harry
  • Daly, Mark J
  • Hattersley, Andrew T
  • Hu, Frank B
  • Meigs, James B
  • Pankow, James S
  • Pedersen, Oluf
  • Wichmann, H - Erich
  • Barroso, Inês
  • Florez, Jose C
  • Frayling, Timothy M
  • Groop, Leif
  • Sladek, Rob
  • Thorsteinsdottir, Unnur
  • Wilson, James F
  • Illig, Thomas
  • Froguel, Philippe
  • Van Duijn, Cornelia M
  • Stefansson, Kari
  • Altshuler, David
  • Boehnke, Michael
  • Mccarthy, Mark I
  • Soranzo, Nicole
  • Wheeler, Eleanor
  • Glazer, Nicole L
  • Bouatia - Naji, Nabila
  • Mägi, Reedik
  • Randall, Joshua
  • Johnson, Toby
  • Elliott, Paul
  • Rybin, Denis
  • Henneman, Peter
  • Dehghan, Abbas
  • Hottenga, Jouke Jan
  • Song, Kijoung
  • Goel, Anuj
  • Egan, Josephine M
  • Lajunen, Taina
  • Doney, Alex
  • Kanoni, Stavroula
  • Cavalcanti - Proença, Christine
  • Kumari, Meena
  • Timpson, Nicholas J
  • Zabena, Carina
  • Ingelsson, Erik
  • An, Ping
  • O'connell, Jeffrey
  • Luan, Jian'an
  • Elliott, Amanda
  • Mccarroll, Steven A
  • Roccasecca, Rosa Maria
  • Pattou, François
  • Sethupathy, Praveen
  • Ariyurek, Yavuz
  • Barter, Philip
  • Beilby, John P
  • Ben - Shlomo, Yoav
  • Bergmann, Sven
  • Bochud, Murielle
  • Bonnefond, Amélie
  • Borch - Johnsen, Knut
  • Böttcher, Yvonne
  • Brunner, Eric
  • Bumpstead, Suzannah J
  • Chen, Yii - Der Ida
  • Chines, Peter
  • Clarke, Robert
  • Coin, Lachlan J M
  • Cooper, Matthew N
  • Crisponi, Laura
  • Day, Ian N M
  • De Geus, Eco J C
  • Delplanque, Jerome
  • Fedson, Annette C
  • Fischer - Rosinsky, Antje
  • Forouhi, Nita G
  • Frants, Rune
  • Franzosi, Maria Grazia
  • Galan, Pilar
  • Goodarzi, Mark O
  • Graessler, Jürgen
  • Grundy, Scott
  • Gwilliam, Rhian
  • Hallmans, Göran
  • Hammond, Naomi
  • Han, Xijing
  • Hartikainen, Anna - Liisa
  • Hayward, Caroline
  • Heath, Simon C
  • Hercberg, Serge
  • Hicks, Andrew A
  • Hillman, David R
  • Hingorani, Aroon D
  • Hui, Jennie
  • Hung, Joe
  • Jula, Antti
  • Kaakinen, Marika
  • Kaprio, Jaakko
  • Kesaniemi, Y Antero
  • Kivimaki, Mika
  • Knight, Beatrice
  • Koskinen, Seppo
  • Kovacs, Peter
  • Kyvik, Kirsten Ohm
  • Lathrop, G Mark
  • Lawlor, Debbie A
  • Le Bacquer, Olivier
  • Lecoeur, Cécile
  • Li, Yun
  • Mahley, Robert
  • Mangino, Massimo
  • Manning, Alisa K
  • Martínez - Larrad, María Teresa
  • Mcateer, Jarred B
  • Mcpherson, Ruth
  • Meisinger, Christa
  • Melzer, David
  • Meyre, David
  • Mitchell, Braxton D
  • Mukherjee, Sutapa
  • Naitza, Silvia
  • Neville, Matthew J
  • Oostra, Ben A
  • Orrù, Marco
  • Pakyz, Ruth
  • Paolisso, Giuseppe
  • Pattaro, Cristian
  • Pearson, Daniel
  • Peden, John F
  • Pedersen, Nancy L
  • Perola, Markus
  • Pfeiffer, Andreas F H
  • Pichler, Irene
  • Polasek, Ozren
  • Posthuma, Danielle
  • Potter, Simon C
  • Pouta, Anneli
  • Province, Michael A
  • Psaty, Bruce M
  • Rayner, Nigel W
  • Rice, Kenneth
  • Ripatti, Samuli
  • Rivadeneira, Fernando
  • Rolandsson, Olov
  • Sandbaek, Annelli
  • Sandhu, Manjinder
  • Sanna, Serena
  • Sayer, Avan Aihie
  • Scheet, Paul
  • Seedorf, Udo
  • Sharp, Stephen J
  • Shields, Beverley
  • Sijbrands, Eric J G
  • Silveira, Angela
  • Simpson, Laila
  • Singleton, Andrew
  • Smith, Nicholas L
  • Sovio, Ulla
  • Swift, Amy
  • Syddall, Holly
  • Syvänen, Ann - Christine
  • Tanaka, Toshiko
  • Tönjes, Anke
  • Uitterlinden, André G
  • Van Dijk, Ko Willems
  • Varma, Dhiraj
  • Visvikis - Siest, Sophie
  • Vitart, Veronique
  • Vogelzangs, Nicole
  • Waeber, Gérard
  • Wagner, Peter J
  • Walley, Andrew
  • Ward, Kim L
  • Watkins, Hugh
  • Wild, Sarah H
  • Willemsen, Gonneke
  • Witteman, Jaqueline C M
  • Yarnell, John W G
  • Zelenika, Diana
  • Zethelius, Björn
  • Zhai, Guangju
  • Zhao, Jing Hua
  • Zillikens, M Carola
  • Borecki, Ingrid B
  • Loos, Ruth J F
  • Meneton, Pierre
  • Magnusson, Patrik K E
  • Nathan, David M
  • Williams, Gordon H
  • Silander, Kaisa
  • Salomaa, Veikko
  • Smith, George Davey
  • Bornstein, Stefan R
  • Schwarz, Peter
  • Spranger, Joachim
  • Karpe, Fredrik
  • Shuldiner, Alan R
  • Cooper, Cyrus
  • Dedoussis, George V
  • Serrano - Ríos, Manuel
  • Lind, Lars
  • Palmer, Lyle J
  • Franks, Paul W
  • Ebrahim, Shah
  • Marmot, Michael
  • Kao, W H Linda
  • Pramstaller, Peter Paul
  • Wright, Alan F
  • Stumvoll, Michael
  • Hamsten, Anders
  • Buchanan, Thomas A
  • Valle, Timo T
  • Rotter, Jerome I
  • Siscovick, David S
  • Penninx, Brenda W J H
  • Boomsma, Dorret I
  • Deloukas, Panos
  • Spector, Timothy D
  • Ferrucci, Luigi
  • Cao, Antonio
  • Scuteri, Angelo
  • Schlessinger, David
  • Uda, Manuela
  • Ruokonen, Aimo
  • Jarvelin, Marjo - Riitta
  • Waterworth, Dawn M
  • Vollenweider, Peter
  • Peltonen, Leena
  • Mooser, Vincent
  • Sladek, Robert
ispartof: Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; +380 more... (2012) A genome-wide association search for type 2 diabetes genes in African Americans. PloS one, 7 (1). e29202
description: African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P
language:
source: London School of Hygiene and Tropical Medicine
identifier: ISSN: 1932-6203
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


@attributes
ID1333715057
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid20693
sourceidlshtm
recordidTN_lshtm20693
sourcesystemPC
display
typearticle
titleA genome-wide association search for type 2 diabetes genes in African Americans
creatorPalmer, Nicholette D ; Mcdonough, Caitrin W ; Hicks, Pamela J ; Roh, Bong H ; Wing, Maria R ; An, S Sandy ; Hester, Jessica M ; Cooke, Jessica N ; Bostrom, Meredith A ; Rudock, Megan E ; Talbert, Matthew E ; Lewis, Joshua P ; Ferrara, Assiamira ; Lu, Lingyi ; Ziegler, Julie T ; Sale, Michele M ; Divers, Jasmin ; Shriner, Daniel ; Adeyemo, Adebowale ; Rotimi, Charles N ; Ng, Maggie C Y ; Langefeld, Carl D ; Freedman, Barry I ; Bowden, Donald W ; Voight, Benjamin F ; Scott, Laura J ; Steinthorsdottir, Valgerdur ; Morris, Andrew P ; Dina, Christian ; Welch, Ryan P ; Zeggini, Eleftheria ; Huth, Cornelia ; Aulchenko, Yurii S ; Thorleifsson, Gudmar ; Mcculloch, Laura J ; Ferreira, Teresa ; Grallert, Harald ; Amin, Najaf ; Wu, Guanming ; Willer, Cristen J ; Raychaudhuri, Soumya ; Mccarroll, Steve A ; Langenberg, Claudia ; Hofmann, Oliver M ; Dupuis, Josée ; Qi, Lu ; Segrè, Ayellet V ; Van Hoek, Mandy ; Navarro, Pau ; Ardlie, Kristin ; Balkau, Beverley ; Benediktsson, Rafn ; Bennett, Amanda J ; Blagieva, Roza ; Boerwinkle, Eric ; Bonnycastle, Lori L ; Boström, Kristina Bengtsson ; Bravenboer, Bert ; Bumpstead, Suzannah ; Burtt, Noël P ; Charpentier, Guillaume ; Chines, Peter S ; Cornelis, Marilyn ; Couper, David J ; Crawford, Gabe ; Doney, Alex S F ; Elliott, Katherine S ; Elliott, Amanda L ; Erdos, Michael R ; Fox, Caroline S ; Franklin, Christopher S ; Ganser, Martha ; Gieger, Christian ; Grarup, Niels ; Green, Todd ; Griffin, Simon ; Groves, Christopher J ; Guiducci, Candace ; Hadjadj, Samy ; Hassanali, Neelam ; Herder, Christian ; Isomaa, Bo ; Jackson, Anne U ; Johnson, Paul R V ; Jørgensen, Torben ; Kao, Wen H L ; Klopp, Norman ; Kong, Augustine ; Kraft, Peter ; Kuusisto, Johanna ; Lauritzen, Torsten ; Li, Man ; Lieverse, Aloysius ; Lindgren, Cecilia M ; Lyssenko, Valeriya ; Marre, Michel ; Meitinger, Thomas ; Midthjell, Kristian ; Morken, Mario A ; Narisu, Narisu ; Nilsson, Peter ; Owen, Katharine R ; Payne, Felicity ; Perry, John R B ; Petersen, Ann - Kristin ; Platou, Carl ; Proença, Christine ; Prokopenko, Inga ; Rathmann, Wolfgang ; Rayner, N William ; Robertson, Neil R ; Rocheleau, Ghislain ; Roden, Michael ; Sampson, Michael J ; Saxena, Richa ; Shields, Beverley M ; Shrader, Peter ; Sigurdsson, Gunnar ; Sparsø, Thomas ; Strassburger, Klaus ; Stringham, Heather M ; Sun, Qi ; Swift, Amy J ; Thorand, Barbara ; Tichet, Jean ; Tuomi, Tiinamaija ; Van Dam, Rob M ; Van Haeften, Timon W ; Van Herpt, Thijs ; Van Vliet - Ostaptchouk, Jana V ; Walters, G Bragi ; Weedon, Michael N ; Wijmenga, Cisca ; Witteman, Jacqueline ; Bergman, Richard N ; Cauchi, Stephane ; Collins, Francis S ; Gloyn, Anna L ; Gyllensten, Ulf ; Hansen, Torben ; Hide, Winston A ; Hitman, Graham A ; Hofman, Albert ; Hunter, David J ; Hveem, Kristian ; Laakso, Markku ; Mohlke, Karen L ; Morris, Andrew D ; Palmer, Colin N A ; Pramstaller, Peter P ; Rudan, Igor ; Sijbrands, Eric ; Stein, Lincoln D ; Tuomilehto, Jaakko ; Uitterlinden, Andre ; Walker, Mark ; Wareham, Nicholas J ; Watanabe, Richard M ; Abecasis, Goncalo R ; Boehm, Bernhard O ; Campbell, Harry ; Daly, Mark J ; Hattersley, Andrew T ; Hu, Frank B ; Meigs, James B ; Pankow, James S ; Pedersen, Oluf ; Wichmann, H - Erich ; Barroso, Inês ; Florez, Jose C ; Frayling, Timothy M ; Groop, Leif ; Sladek, Rob ; Thorsteinsdottir, Unnur ; Wilson, James F ; Illig, Thomas ; Froguel, Philippe ; Van Duijn, Cornelia M ; Stefansson, Kari ; Altshuler, David ; Boehnke, Michael ; Mccarthy, Mark I ; Soranzo, Nicole ; Wheeler, Eleanor ; Glazer, Nicole L ; Bouatia - Naji, Nabila ; Mägi, Reedik ; Randall, Joshua ; Johnson, Toby ; Elliott, Paul ; Rybin, Denis ; Henneman, Peter ; Dehghan, Abbas ; Hottenga, Jouke Jan ; Song, Kijoung ; Goel, Anuj ; Egan, Josephine M ; Lajunen, Taina ; Doney, Alex ; Kanoni, Stavroula ; Cavalcanti - Proença, Christine ; Kumari, Meena ; Timpson, Nicholas J ; Zabena, Carina ; Ingelsson, Erik ; An, Ping ; O'connell, Jeffrey ; Luan, Jian'an ; Elliott, Amanda ; Mccarroll, Steven A ; Roccasecca, Rosa Maria ; Pattou, François ; Sethupathy, Praveen ; Ariyurek, Yavuz ; Barter, Philip ; Beilby, John P ; Ben - Shlomo, Yoav ; Bergmann, Sven ; Bochud, Murielle ; Bonnefond, Amélie ; Borch - Johnsen, Knut ; Böttcher, Yvonne ; Brunner, Eric ; Bumpstead, Suzannah J ; Chen, Yii - Der Ida ; Chines, Peter ; Clarke, Robert ; Coin, Lachlan J M ; Cooper, Matthew N ; Crisponi, Laura ; Day, Ian N M ; De Geus, Eco J C ; Delplanque, Jerome ; Fedson, Annette C ; Fischer - Rosinsky, Antje ; Forouhi, Nita G ; Frants, Rune ; Franzosi, Maria Grazia ; Galan, Pilar ; Goodarzi, Mark O ; Graessler, Jürgen ; Grundy, Scott ; Gwilliam, Rhian ; Hallmans, Göran ; Hammond, Naomi ; Han, Xijing ; Hartikainen, Anna - Liisa ; Hayward, Caroline ; Heath, Simon C ; Hercberg, Serge ; Hicks, Andrew A ; Hillman, David R ; Hingorani, Aroon D ; Hui, Jennie ; Hung, Joe ; Jula, Antti ; Kaakinen, Marika ; Kaprio, Jaakko ; Kesaniemi, Y Antero ; Kivimaki, Mika ; Knight, Beatrice ; Koskinen, Seppo ; Kovacs, Peter ; Kyvik, Kirsten Ohm ; Lathrop, G Mark ; Lawlor, Debbie A ; Le Bacquer, Olivier ; Lecoeur, Cécile ; Li, Yun ; Mahley, Robert ; Mangino, Massimo ; Manning, Alisa K ; Martínez - Larrad, María Teresa ; Mcateer, Jarred B ; Mcpherson, Ruth ; Meisinger, Christa ; Melzer, David ; Meyre, David ; Mitchell, Braxton D ; Mukherjee, Sutapa ; Naitza, Silvia ; Neville, Matthew J ; Oostra, Ben A ; Orrù, Marco ; Pakyz, Ruth ; Paolisso, Giuseppe ; Pattaro, Cristian ; Pearson, Daniel ; Peden, John F ; Pedersen, Nancy L ; Perola, Markus ; Pfeiffer, Andreas F H ; Pichler, Irene ; Polasek, Ozren ; Posthuma, Danielle ; Potter, Simon C ; Pouta, Anneli ; Province, Michael A ; Psaty, Bruce M ; Rayner, Nigel W ; Rice, Kenneth ; Ripatti, Samuli ; Rivadeneira, Fernando ; Rolandsson, Olov ; Sandbaek, Annelli ; Sandhu, Manjinder ; Sanna, Serena ; Sayer, Avan Aihie ; Scheet, Paul ; Seedorf, Udo ; Sharp, Stephen J ; Shields, Beverley ; Sijbrands, Eric J G ; Silveira, Angela ; Simpson, Laila ; Singleton, Andrew ; Smith, Nicholas L ; Sovio, Ulla ; Swift, Amy ; Syddall, Holly ; Syvänen, Ann - Christine ; Tanaka, Toshiko ; Tönjes, Anke ; Uitterlinden, André G ; Van Dijk, Ko Willems ; Varma, Dhiraj ; Visvikis - Siest, Sophie ; Vitart, Veronique ; Vogelzangs, Nicole ; Waeber, Gérard ; Wagner, Peter J ; Walley, Andrew ; Ward, Kim L ; Watkins, Hugh ; Wild, Sarah H ; Willemsen, Gonneke ; Witteman, Jaqueline C M ; Yarnell, John W G ; Zelenika, Diana ; Zethelius, Björn ; Zhai, Guangju ; Zhao, Jing Hua ; Zillikens, M Carola ; Borecki, Ingrid B ; Loos, Ruth J F ; Meneton, Pierre ; Magnusson, Patrik K E ; Nathan, David M ; Williams, Gordon H ; Silander, Kaisa ; Salomaa, Veikko ; Smith, George Davey ; Bornstein, Stefan R ; Schwarz, Peter ; Spranger, Joachim ; Karpe, Fredrik ; Shuldiner, Alan R ; Cooper, Cyrus ; Dedoussis, George V ; Serrano - Ríos, Manuel ; Lind, Lars ; Palmer, Lyle J ; Franks, Paul W ; Ebrahim, Shah ; Marmot, Michael ; Kao, W H Linda ; Pramstaller, Peter Paul ; Wright, Alan F ; Stumvoll, Michael ; Hamsten, Anders ; Buchanan, Thomas A ; Valle, Timo T ; Rotter, Jerome I ; Siscovick, David S ; Penninx, Brenda W J H ; Boomsma, Dorret I ; Deloukas, Panos ; Spector, Timothy D ; Ferrucci, Luigi ; Cao, Antonio ; Scuteri, Angelo ; Schlessinger, David ; Uda, Manuela ; Ruokonen, Aimo ; Jarvelin, Marjo - Riitta ; Waterworth, Dawn M ; Vollenweider, Peter ; Peltonen, Leena ; Mooser, Vincent ; Sladek, Robert
ispartofPalmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; +380 more... (2012) A genome-wide association search for type 2 diabetes genes in African Americans. PloS one, 7 (1). e29202
identifier ISSN: 1932-6203
descriptionAfrican Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
sourceLondon School of Hygiene and Tropical Medicine
oafree_for_read
lds50peer_reviewed
links
openurl$$Topenurl_article
linktorsrc$$Uhttp://researchonline.lshtm.ac.uk/20693/$$EView_full_text_in_LSHTM_Research_Online
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Palmer, Nicholette D
1Mcdonough, Caitrin W
2Hicks, Pamela J
3Roh, Bong H
4Wing, Maria R
5An, S Sandy
6Hester, Jessica M
7Cooke, Jessica N
8Bostrom, Meredith A
9Rudock, Megan E
10Talbert, Matthew E
11Lewis, Joshua P
12Ferrara, Assiamira
13Lu, Lingyi
14Ziegler, Julie T
15Sale, Michele M
16Divers, Jasmin
17Shriner, Daniel
18Adeyemo, Adebowale
19Rotimi, Charles N
20Ng, Maggie C Y
21Langefeld, Carl D
22Freedman, Barry I
23Bowden, Donald W
24Voight, Benjamin F
25Scott, Laura J
26Steinthorsdottir, Valgerdur
27Morris, Andrew P
28Dina, Christian
29Welch, Ryan P
30Zeggini, Eleftheria
31Huth, Cornelia
32Aulchenko, Yurii S
33Thorleifsson, Gudmar
34Mcculloch, Laura J
35Ferreira, Teresa
36Grallert, Harald
37Amin, Najaf
38Wu, Guanming
39Willer, Cristen J
40Raychaudhuri, Soumya
41Mccarroll, Steve A
42Langenberg, Claudia
43Hofmann, Oliver M
44Dupuis, Josée
45Qi, Lu
46Segrè, Ayellet V
47Van Hoek, Mandy
48Navarro, Pau
49Ardlie, Kristin
50Balkau, Beverley
51Benediktsson, Rafn
52Bennett, Amanda J
53Blagieva, Roza
54Boerwinkle, Eric
55Bonnycastle, Lori L
56Boström, Kristina Bengtsson
57Bravenboer, Bert
58Bumpstead, Suzannah
59Burtt, Noël P
60Charpentier, Guillaume
61Chines, Peter S
62Cornelis, Marilyn
63Couper, David J
64Crawford, Gabe
65Doney, Alex S F
66Elliott, Katherine S
67Elliott, Amanda L
68Erdos, Michael R
69Fox, Caroline S
70Franklin, Christopher S
71Ganser, Martha
72Gieger, Christian
73Grarup, Niels
74Green, Todd
75Griffin, Simon
76Groves, Christopher J
77Guiducci, Candace
78Hadjadj, Samy
79Hassanali, Neelam
80Herder, Christian
81Isomaa, Bo
82Jackson, Anne U
83Johnson, Paul R V
84Jørgensen, Torben
85Kao, Wen H L
86Klopp, Norman
87Kong, Augustine
88Kraft, Peter
89Kuusisto, Johanna
90Lauritzen, Torsten
91Li, Man
92Lieverse, Aloysius
93Lindgren, Cecilia M
94Lyssenko, Valeriya
95Marre, Michel
96Meitinger, Thomas
97Midthjell, Kristian
98Morken, Mario A
99Narisu, Narisu
100...
titleA genome-wide association search for type 2 diabetes genes in African Americans
descriptionAfrican Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
general
0Public Library of Science
1LSHTM Research Online (London School of Hygiene and Tropical Medicine)
sourceidlshtm
recordidlshtm20693
issn
019326203
11932-6203
rsrctypearticle
creationdate2012
searchscopelshtm
scopelshtm
sort
titleA genome-wide association search for type 2 diabetes genes in African Americans
authorPalmer, Nicholette D ; Mcdonough, Caitrin W ; Hicks, Pamela J ; Roh, Bong H ; Wing, Maria R ; An, S Sandy ; Hester, Jessica M ; Cooke, Jessica N ; Bostrom, Meredith A ; Rudock, Megan E ; Talbert, Matthew E ; Lewis, Joshua P ; Ferrara, Assiamira ; Lu, Lingyi ; Ziegler, Julie T ; Sale, Michele M ; Divers, Jasmin ; Shriner, Daniel ; Adeyemo, Adebowale ; Rotimi, Charles N ; Ng, Maggie C Y ; Langefeld, Carl D ; Freedman, Barry I ; Bowden, Donald W ; Voight, Benjamin F ; Scott, Laura J ; Steinthorsdottir, Valgerdur ; Morris, Andrew P ; Dina, Christian ; Welch, Ryan P ; Zeggini, Eleftheria ; Huth, Cornelia ; Aulchenko, Yurii S ; Thorleifsson, Gudmar ; Mcculloch, Laura J ; Ferreira, Teresa ; Grallert, Harald ; Amin, Najaf ; Wu, Guanming ; Willer, Cristen J ; Raychaudhuri, Soumya ; Mccarroll, Steve A ; Langenberg, Claudia ; Hofmann, Oliver M ; Dupuis, Josée ; Qi, Lu ; Segrè, Ayellet V ; Van Hoek, Mandy ; Navarro, Pau ; Ardlie, Kristin ; Balkau, Beverley ; Benediktsson, Rafn ; Bennett, Amanda J ; Blagieva, Roza ; Boerwinkle, Eric ; Bonnycastle, Lori L ; Boström, Kristina Bengtsson ; Bravenboer, Bert ; Bumpstead, Suzannah ; Burtt, Noël P ; Charpentier, Guillaume ; Chines, Peter S ; Cornelis, Marilyn ; Couper, David J ; Crawford, Gabe ; Doney, Alex S F ; Elliott, Katherine S ; Elliott, Amanda L ; Erdos, Michael R ; Fox, Caroline S ; Franklin, Christopher S ; Ganser, Martha ; Gieger, Christian ; Grarup, Niels ; Green, Todd ; Griffin, Simon ; Groves, Christopher J ; Guiducci, Candace ; Hadjadj, Samy ; Hassanali, Neelam ; Herder, Christian ; Isomaa, Bo ; Jackson, Anne U ; Johnson, Paul R V ; Jørgensen, Torben ; Kao, Wen H L ; Klopp, Norman ; Kong, Augustine ; Kraft, Peter ; Kuusisto, Johanna ; Lauritzen, Torsten ; Li, Man ; Lieverse, Aloysius ; Lindgren, Cecilia M ; Lyssenko, Valeriya ; Marre, Michel ; Meitinger, Thomas ; Midthjell, Kristian ; Morken, Mario A ; Narisu, Narisu ; Nilsson, Peter ; Owen, Katharine R ; Payne, Felicity ; Perry, John R B ; Petersen, Ann - Kristin ; Platou, Carl ; Proença, Christine ; Prokopenko, Inga ; Rathmann, Wolfgang ; Rayner, N William ; Robertson, Neil R ; Rocheleau, Ghislain ; Roden, Michael ; Sampson, Michael J ; Saxena, Richa ; Shields, Beverley M ; Shrader, Peter ; Sigurdsson, Gunnar ; Sparsø, Thomas ; Strassburger, Klaus ; Stringham, Heather M ; Sun, Qi ; Swift, Amy J ; Thorand, Barbara ; Tichet, Jean ; Tuomi, Tiinamaija ; Van Dam, Rob M ; Van Haeften, Timon W ; Van Herpt, Thijs ; Van Vliet - Ostaptchouk, Jana V ; Walters, G Bragi ; Weedon, Michael N ; Wijmenga, Cisca ; Witteman, Jacqueline ; Bergman, Richard N ; Cauchi, Stephane ; Collins, Francis S ; Gloyn, Anna L ; Gyllensten, Ulf ; Hansen, Torben ; Hide, Winston A ; Hitman, Graham A ; Hofman, Albert ; Hunter, David J ; Hveem, Kristian ; Laakso, Markku ; Mohlke, Karen L ; Morris, Andrew D ; Palmer, Colin N A ; Pramstaller, Peter P ; Rudan, Igor ; Sijbrands, Eric ; Stein, Lincoln D ; Tuomilehto, Jaakko ; Uitterlinden, Andre ; Walker, Mark ; Wareham, Nicholas J ; Watanabe, Richard M ; Abecasis, Goncalo R ; Boehm, Bernhard O ; Campbell, Harry ; Daly, Mark J ; Hattersley, Andrew T ; Hu, Frank B ; Meigs, James B ; Pankow, James S ; Pedersen, Oluf ; Wichmann, H - Erich ; Barroso, Inês ; Florez, Jose C ; Frayling, Timothy M ; Groop, Leif ; Sladek, Rob ; Thorsteinsdottir, Unnur ; Wilson, James F ; Illig, Thomas ; Froguel, Philippe ; Van Duijn, Cornelia M ; Stefansson, Kari ; Altshuler, David ; Boehnke, Michael ; Mccarthy, Mark I ; Soranzo, Nicole ; Wheeler, Eleanor ; Glazer, Nicole L ; Bouatia - Naji, Nabila ; Mägi, Reedik ; Randall, Joshua ; Johnson, Toby ; Elliott, Paul ; Rybin, Denis ; Henneman, Peter ; Dehghan, Abbas ; Hottenga, Jouke Jan ; Song, Kijoung ; Goel, Anuj ; Egan, Josephine M ; Lajunen, Taina ; Doney, Alex ; Kanoni, Stavroula ; Cavalcanti - Proença, Christine ; Kumari, Meena ; Timpson, Nicholas J ; Zabena, Carina ; Ingelsson, Erik ; An, Ping ; O'connell, Jeffrey ; Luan, Jian'an ; Elliott, Amanda ; Mccarroll, Steven A ; Roccasecca, Rosa Maria ; Pattou, François ; Sethupathy, Praveen ; Ariyurek, Yavuz ; Barter, Philip ; Beilby, John P ; Ben - Shlomo, Yoav ; Bergmann, Sven ; Bochud, Murielle ; Bonnefond, Amélie ; Borch - Johnsen, Knut ; Böttcher, Yvonne ; Brunner, Eric ; Bumpstead, Suzannah J ; Chen, Yii - Der Ida ; Chines, Peter ; Clarke, Robert ; Coin, Lachlan J M ; Cooper, Matthew N ; Crisponi, Laura ; Day, Ian N M ; De Geus, Eco J C ; Delplanque, Jerome ; Fedson, Annette C ; Fischer - Rosinsky, Antje ; Forouhi, Nita G ; Frants, Rune ; Franzosi, Maria Grazia ; Galan, Pilar ; Goodarzi, Mark O ; Graessler, Jürgen ; Grundy, Scott ; Gwilliam, Rhian ; Hallmans, Göran ; Hammond, Naomi ; Han, Xijing ; Hartikainen, Anna - Liisa ; Hayward, Caroline ; Heath, Simon C ; Hercberg, Serge ; Hicks, Andrew A ; Hillman, David R ; Hingorani, Aroon D ; Hui, Jennie ; Hung, Joe ; Jula, Antti ; Kaakinen, Marika ; Kaprio, Jaakko ; Kesaniemi, Y Antero ; Kivimaki, Mika ; Knight, Beatrice ; Koskinen, Seppo ; Kovacs, Peter ; Kyvik, Kirsten Ohm ; Lathrop, G Mark ; Lawlor, Debbie A ; Le Bacquer, Olivier ; Lecoeur, Cécile ; Li, Yun ; Mahley, Robert ; Mangino, Massimo ; Manning, Alisa K ; Martínez - Larrad, María Teresa ; Mcateer, Jarred B ; Mcpherson, Ruth ; Meisinger, Christa ; Melzer, David ; Meyre, David ; Mitchell, Braxton D ; Mukherjee, Sutapa ; Naitza, Silvia ; Neville, Matthew J ; Oostra, Ben A ; Orrù, Marco ; Pakyz, Ruth ; Paolisso, Giuseppe ; Pattaro, Cristian ; Pearson, Daniel ; Peden, John F ; Pedersen, Nancy L ; Perola, Markus ; Pfeiffer, Andreas F H ; Pichler, Irene ; Polasek, Ozren ; Posthuma, Danielle ; Potter, Simon C ; Pouta, Anneli ; Province, Michael A ; Psaty, Bruce M ; Rayner, Nigel W ; Rice, Kenneth ; Ripatti, Samuli ; Rivadeneira, Fernando ; Rolandsson, Olov ; Sandbaek, Annelli ; Sandhu, Manjinder ; Sanna, Serena ; Sayer, Avan Aihie ; Scheet, Paul ; Seedorf, Udo ; Sharp, Stephen J ; Shields, Beverley ; Sijbrands, Eric J G ; Silveira, Angela ; Simpson, Laila ; Singleton, Andrew ; Smith, Nicholas L ; Sovio, Ulla ; Swift, Amy ; Syddall, Holly ; Syvänen, Ann - Christine ; Tanaka, Toshiko ; Tönjes, Anke ; Uitterlinden, André G ; Van Dijk, Ko Willems ; Varma, Dhiraj ; Visvikis - Siest, Sophie ; Vitart, Veronique ; Vogelzangs, Nicole ; Waeber, Gérard ; Wagner, Peter J ; Walley, Andrew ; Ward, Kim L ; Watkins, Hugh ; Wild, Sarah H ; Willemsen, Gonneke ; Witteman, Jaqueline C M ; Yarnell, John W G ; Zelenika, Diana ; Zethelius, Björn ; Zhai, Guangju ; Zhao, Jing Hua ; Zillikens, M Carola ; Borecki, Ingrid B ; Loos, Ruth J F ; Meneton, Pierre ; Magnusson, Patrik K E ; Nathan, David M ; Williams, Gordon H ; Silander, Kaisa ; Salomaa, Veikko ; Smith, George Davey ; Bornstein, Stefan R ; Schwarz, Peter ; Spranger, Joachim ; Karpe, Fredrik ; Shuldiner, Alan R ; Cooper, Cyrus ; Dedoussis, George V ; Serrano - Ríos, Manuel ; Lind, Lars ; Palmer, Lyle J ; Franks, Paul W ; Ebrahim, Shah ; Marmot, Michael ; Kao, W H Linda ; Pramstaller, Peter Paul ; Wright, Alan F ; Stumvoll, Michael ; Hamsten, Anders ; Buchanan, Thomas A ; Valle, Timo T ; Rotter, Jerome I ; Siscovick, David S ; Penninx, Brenda W J H ; Boomsma, Dorret I ; Deloukas, Panos ; Spector, Timothy D ; Ferrucci, Luigi ; Cao, Antonio ; Scuteri, Angelo ; Schlessinger, David ; Uda, Manuela ; Ruokonen, Aimo ; Jarvelin, Marjo - Riitta ; Waterworth, Dawn M ; Vollenweider, Peter ; Peltonen, Leena ; Mooser, Vincent ; Sladek, Robert
creationdate20120000
facets
frbrgroupid1717406859359158872
frbrtype6
creationdate2012
collectionLSHTM Research Online (London School of Hygiene and Tropical Medicine)
prefilterarticles
rsrctypearticles
creatorcontrib
0Palmer, Nicholette D
1Mcdonough, Caitrin W
2Hicks, Pamela J
3Roh, Bong H
4Wing, Maria R
5An, S Sandy
6Hester, Jessica M
7Cooke, Jessica N
8Bostrom, Meredith A
9Rudock, Megan E
10Talbert, Matthew E
11Lewis, Joshua P
12Ferrara, Assiamira
13Lu, Lingyi
14Ziegler, Julie T
15Sale, Michele M
16Divers, Jasmin
17Shriner, Daniel
18Adeyemo, Adebowale
19Rotimi, Charles N
20Ng, Maggie C Y
21Langefeld, Carl D
22Freedman, Barry I
23Bowden, Donald W
24Voight, Benjamin F
25Scott, Laura J
26Steinthorsdottir, Valgerdur
27Morris, Andrew P
28Dina, Christian
29Welch, Ryan P
30Zeggini, Eleftheria
31Huth, Cornelia
32Aulchenko, Yurii S
33Thorleifsson, Gudmar
34Mcculloch, Laura J
35Ferreira, Teresa
36Grallert, Harald
37Amin, Najaf
38Wu, Guanming
39Willer, Cristen J
40Raychaudhuri, Soumya
41Mccarroll, Steve A
42Langenberg, Claudia
43Hofmann, Oliver M
44Dupuis, Josée
45Qi, Lu
46Segrè, Ayellet V
47Van Hoek, Mandy
48Navarro, Pau
49Ardlie, Kristin
50Balkau, Beverley
51Benediktsson, Rafn
52Bennett, Amanda J
53Blagieva, Roza
54Boerwinkle, Eric
55Bonnycastle, Lori L
56Boström, Kristina Bengtsson
57Bravenboer, Bert
58Bumpstead, Suzannah
59Burtt, Noël P
60Charpentier, Guillaume
61Chines, Peter S
62Cornelis, Marilyn
63Couper, David J
64Crawford, Gabe
65Doney, Alex S F
66Elliott, Katherine S
67Elliott, Amanda L
68Erdos, Michael R
69Fox, Caroline S
70Franklin, Christopher S
71Ganser, Martha
72Gieger, Christian
73Grarup, Niels
74Green, Todd
75Griffin, Simon
76Groves, Christopher J
77Guiducci, Candace
78Hadjadj, Samy
79Hassanali, Neelam
80Herder, Christian
81Isomaa, Bo
82Jackson, Anne U
83Johnson, Paul R V
84Jørgensen, Torben
85Kao, Wen H L
86Klopp, Norman
87Kong, Augustine
88Kraft, Peter
89Kuusisto, Johanna
90Lauritzen, Torsten
91Li, Man
92Lieverse, Aloysius
93Lindgren, Cecilia M
94Lyssenko, Valeriya
95Marre, Michel
96Meitinger, Thomas
97Midthjell, Kristian
98Morken, Mario A
99Narisu, Narisu
100...
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
aulast
0Palmer
1McDonough
2Hicks
3Roh
4Wing
5An
6Hester
7Cooke
8Bostrom
9Rudock
10Talbert
11Lewis
12Ferrara
13Lu
14Ziegler
15Sale
16Divers
17Shriner
18Adeyemo
19Rotimi
20Ng
21Langefeld
22Freedman
23Bowden
24Voight
25Scott
26Steinthorsdottir
27Morris
28Dina
29Welch
30Zeggini
31Huth
32Aulchenko
33Thorleifsson
34McCulloch
35Ferreira
36Grallert
37Amin
38Wu
39Willer
40Raychaudhuri
41McCarroll
42Langenberg
43Hofmann
44Dupuis
45Qi
46Segrè
47van Hoek
48Navarro
49Ardlie
50Balkau
51Benediktsson
52Bennett
53Blagieva
54Boerwinkle
55Bonnycastle
56Boström
57Bravenboer
58Bumpstead
59Burtt
60Charpentier
61Chines
62Cornelis
63Couper
64Crawford
65Doney
66Elliott
67Erdos
68Fox
69Franklin
70Ganser
71Gieger
72Grarup
73Green
74Griffin
75Groves
76Guiducci
77Hadjadj
78Hassanali
79Herder
80Isomaa
81Jackson
82Johnson
83Jørgensen
84Kao
85Klopp
86Kong
87Kraft
88Kuusisto
89Lauritzen
90Li
91Lieverse
92Lindgren
93Lyssenko
94Marre
95Meitinger
96Midthjell
97Morken
98Narisu
99Nilsson
100...
aufirst
0Nicholette D
1Caitrin W
2Pamela J
3Bong H
4Maria R
5S Sandy
6Jessica M
7Jessica N
8Meredith A
9Megan E
10Matthew E
11Joshua P
12Assiamira
13Lingyi
14Julie T
15Michele M
16Jasmin
17Daniel
18Adebowale
19Charles N
20Maggie C Y
21Carl D
22Barry I
23Donald W
24Benjamin F
25Laura J
26Valgerdur
27Andrew P
28Christian
29Ryan P
30Eleftheria
31Cornelia
32Yurii S
33Gudmar
34Teresa
35Harald
36Najaf
37Guanming
38Cristen J
39Soumya
40Steve A
41Claudia
42Oliver M
43Josée
44Lu
45Ayellet V
46Mandy
47Pau
48Kristin
49Beverley
50Rafn
51Amanda J
52Roza
53Eric
54Lori L
55Kristina Bengtsson
56Bert
57Suzannah
58Noël P
59Guillaume
60Peter S
61Marilyn
62David J
63Gabe
64Alex S F
65Katherine S
66Amanda L
67Michael R
68Caroline S
69Christopher S
70Martha
71Niels
72Todd
73Simon
74Christopher J
75Candace
76Samy
77Neelam
78Bo
79Anne U
80Paul R V
81Torben
82Wen H L
83Norman
84Augustine
85Peter
86Johanna
87Torsten
88Man
89Aloysius
90Cecilia M
91Valeriya
92Michel
93Thomas
94Kristian
95Mario A
96Narisu
97Katharine R
98Felicity
99John R B
100...
au
0Palmer, Nicholette D
1Mcdonough, Caitrin W
2Hicks, Pamela J
3Roh, Bong H
4Wing, Maria R
5An, S Sandy
6Hester, Jessica M
7Cooke, Jessica N
8Bostrom, Meredith A
9Rudock, Megan E
10Talbert, Matthew E
11Lewis, Joshua P
12Ferrara, Assiamira
13Lu, Lingyi
14Ziegler, Julie T
15Sale, Michele M
16Divers, Jasmin
17Shriner, Daniel
18Adeyemo, Adebowale
19Rotimi, Charles N
20Ng, Maggie C Y
21Langefeld, Carl D
22Freedman, Barry I
23Bowden, Donald W
24Voight, Benjamin F
25Scott, Laura J
26Steinthorsdottir, Valgerdur
27Morris, Andrew P
28Dina, Christian
29Welch, Ryan P
30Zeggini, Eleftheria
31Huth, Cornelia
32Aulchenko, Yurii S
33Thorleifsson, Gudmar
34Mcculloch, Laura J
35Ferreira, Teresa
36Grallert, Harald
37Amin, Najaf
38Wu, Guanming
39Willer, Cristen J
40Raychaudhuri, Soumya
41Mccarroll, Steve A
42Langenberg, Claudia
43Hofmann, Oliver M
44Dupuis, Josée
45Qi, Lu
46Segrè, Ayellet V
47Van Hoek, Mandy
48Navarro, Pau
49Ardlie, Kristin
50Balkau, Beverley
51Benediktsson, Rafn
52Bennett, Amanda J
53Blagieva, Roza
54Boerwinkle, Eric
55Bonnycastle, Lori L
56Boström, Kristina Bengtsson
57Bravenboer, Bert
58Bumpstead, Suzannah
59Burtt, Noël P
60Charpentier, Guillaume
61Chines, Peter S
62Cornelis, Marilyn
63Couper, David J
64Crawford, Gabe
65Doney, Alex S F
66Elliott, Katherine S
67Elliott, Amanda L
68Erdos, Michael R
69Fox, Caroline S
70Franklin, Christopher S
71Ganser, Martha
72Gieger, Christian
73Grarup, Niels
74Green, Todd
75Griffin, Simon
76Groves, Christopher J
77Guiducci, Candace
78Hadjadj, Samy
79Hassanali, Neelam
80Herder, Christian
81Isomaa, Bo
82Jackson, Anne U
83Johnson, Paul R V
84Jørgensen, Torben
85Kao, Wen H L
86Klopp, Norman
87Kong, Augustine
88Kraft, Peter
89Kuusisto, Johanna
90Lauritzen, Torsten
91Li, Man
92Lieverse, Aloysius
93Lindgren, Cecilia M
94Lyssenko, Valeriya
95Marre, Michel
96Meitinger, Thomas
97Midthjell, Kristian
98Morken, Mario A
99Narisu, Narisu
100...
atitleA genome-wide association search for type 2 diabetes genes in African Americans
date2012
risdate2012
issn1932-6203
genrearticle
ristypeJOUR
abstractAfrican Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
pubPublic Library of Science
formatarticle
oafree_for_read