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Effect of Cyclosporin A and Tacrolimus on Sister Chromatid Exchange Frequency in Renal Transplant Patients

Long-term use of Cyclosporin A (CsA) and Tacrolimus is known to yield serious untoward side effects including nephrotoxicity, neurotoxicity, and malignant tumor formation. Sister chromatid exchange (SCE) is used to assess the genotoxic potential of various agents. A total of 37 postrenal transplant... Full description

Journal Title: Genetic Testing 01 September 2008, Vol.12(3), pp.427-430
Main Author: Öztürk, Ükrü
Other Authors: Ayna, Tülay K , Çefle, K Vanç , Palanduz, Ükrü , Çiftçi, Hayriye , Kaya, Selvi A , Diler, A. Sarper , Türkmen, Ayd N , Gürtekin, Mehmet , Sever, Mehmet Ükrü , Çarin, Mahmut
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1090-6576 ; E-ISSN: 1557-7473 ; DOI: 10.1089/gte.2008.0006
Link: https://www.liebertpub.com/doi/abs/10.1089/gte.2008.0006
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recordid: maryannliebert_s10_1089_gte_2008_0006
title: Effect of Cyclosporin A and Tacrolimus on Sister Chromatid Exchange Frequency in Renal Transplant Patients
format: Article
creator:
  • Öztürk, Ükrü
  • Ayna, Tülay K
  • Çefle, K Vanç
  • Palanduz, Ükrü
  • Çiftçi, Hayriye
  • Kaya, Selvi A
  • Diler, A. Sarper
  • Türkmen, Ayd N
  • Gürtekin, Mehmet
  • Sever, Mehmet Ükrü
  • Çarin, Mahmut
subjects:
  • Medicine
  • Biology
ispartof: Genetic Testing, 01 September 2008, Vol.12(3), pp.427-430
description: Long-term use of Cyclosporin A (CsA) and Tacrolimus is known to yield serious untoward side effects including nephrotoxicity, neurotoxicity, and malignant tumor formation. Sister chromatid exchange (SCE) is used to assess the genotoxic potential of various agents. A total of 37 postrenal transplant patients receiving either CsA ( n = 20) or Tacrolimus ( n = 17) were included in this study. The genotoxic effects of CsA and Tacrolimus were assessed by determination of SCE frequency. In patients receiving CsA, SCE frequency was increased significantly compared to that in the control group ( p = 0.001), whereas Tacrolimus did not yield such a significant change ( p = 0.801). SCE frequency was not correlated with drug dosage ( p > 0.05). Our results indicate that the use of CsA, but not Tacrolimus 506, is associated with an increased genotoxic effect in postrenal transplant patients.
language: eng
source:
identifier: ISSN: 1090-6576 ; E-ISSN: 1557-7473 ; DOI: 10.1089/gte.2008.0006
fulltext: fulltext
issn:
  • 1090-6576
  • 10906576
  • 1557-7473
  • 15577473
url: Link


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titleEffect of Cyclosporin A and Tacrolimus on Sister Chromatid Exchange Frequency in Renal Transplant Patients
creatorÖztürk, Ükrü ; Ayna, Tülay K ; Çefle, K Vanç ; Palanduz, Ükrü ; Çiftçi, Hayriye ; Kaya, Selvi A ; Diler, A. Sarper ; Türkmen, Ayd N ; Gürtekin, Mehmet ; Sever, Mehmet Ükrü ; Çarin, Mahmut
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subjectMedicine ; Biology
descriptionLong-term use of Cyclosporin A (CsA) and Tacrolimus is known to yield serious untoward side effects including nephrotoxicity, neurotoxicity, and malignant tumor formation. Sister chromatid exchange (SCE) is used to assess the genotoxic potential of various agents. A total of 37 postrenal transplant patients receiving either CsA ( n = 20) or Tacrolimus ( n = 17) were included in this study. The genotoxic effects of CsA and Tacrolimus were assessed by determination of SCE frequency. In patients receiving CsA, SCE frequency was increased significantly compared to that in the control group ( p = 0.001), whereas Tacrolimus did not yield such a significant change ( p = 0.801). SCE frequency was not correlated with drug dosage ( p > 0.05). Our results indicate that the use of CsA, but not Tacrolimus 506, is associated with an increased genotoxic effect in postrenal transplant patients.
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