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Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures

Marijuana and related drugs (cannabinoids) have been proposed as treatments for a widening spectrum of medical disorders. R(+)-[2, 3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1, 4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (R(+)-WIN 55212-2), a synthetic cannabinoid agonist, d... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience 15 April 1999, Vol.19(8), pp.2987-95
Main Author: Nagayama, T
Other Authors: Sinor, A D , Simon, R P , Chen, J , Graham, S H , Jin, K , Greenberg, D A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0270-6474 ; PMID: 10191316 Version:1
Link: http://pubmed.gov/10191316
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recordid: medline10191316
title: Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
format: Article
creator:
  • Nagayama, T
  • Sinor, A D
  • Simon, R P
  • Chen, J
  • Graham, S H
  • Jin, K
  • Greenberg, D A
subjects:
  • Brain Ischemia -- Drug Therapy
  • Cannabinoids -- Therapeutic Use
  • Ischemic Attack, Transient -- Drug Therapy
  • Neurons -- Drug Effects
  • Neuroprotective Agents -- Therapeutic Use
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, 15 April 1999, Vol.19(8), pp.2987-95
description: Marijuana and related drugs (cannabinoids) have been proposed as treatments for a widening spectrum of medical disorders. R(+)-[2, 3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1, 4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (R(+)-WIN 55212-2), a synthetic cannabinoid agonist, decreased hippocampal neuronal loss after transient global cerebral ischemia and reduced infarct volume after permanent focal cerebral ischemia induced by middle cerebral artery occlusion in rats. The less active enantiomer S(-)-WIN 55212-3 was ineffective, and the protective effect of R(+)-WIN 55212-2 was blocked by the specific central cannabinoid (CB1) cannabinoid receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide-hydrochloride. R(+)-WIN 55212-2 also protected cultured cerebral cortical neurons from in vitro hypoxia and glucose deprivation, but in contrast to the receptor-mediated neuroprotection observed in vivo, this in vitro...
language: eng
source:
identifier: ISSN: 0270-6474 ; PMID: 10191316 Version:1
fulltext: fulltext
issn:
  • 02706474
  • 0270-6474
url: Link


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titleCannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
creatorNagayama, T ; Sinor, A D ; Simon, R P ; Chen, J ; Graham, S H ; Jin, K ; Greenberg, D A
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subjectBrain Ischemia -- Drug Therapy ; Cannabinoids -- Therapeutic Use ; Ischemic Attack, Transient -- Drug Therapy ; Neurons -- Drug Effects ; Neuroprotective Agents -- Therapeutic Use
descriptionMarijuana and related drugs (cannabinoids) have been proposed as treatments for a widening spectrum of medical disorders. R(+)-[2, 3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1, 4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (R(+)-WIN 55212-2), a synthetic cannabinoid agonist, decreased hippocampal neuronal loss after transient global cerebral ischemia and reduced infarct volume after permanent focal cerebral ischemia induced by middle cerebral artery occlusion in rats. The less active enantiomer S(-)-WIN 55212-3 was ineffective, and the protective effect of R(+)-WIN 55212-2 was blocked by the specific central cannabinoid (CB1) cannabinoid receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide-hydrochloride. R(+)-WIN 55212-2 also protected cultured cerebral cortical neurons from in vitro hypoxia and glucose deprivation, but in contrast to the receptor-mediated neuroprotection observed in vivo, this in vitro...
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descriptionMarijuana and related drugs (cannabinoids) have been proposed as treatments for a widening spectrum of medical disorders. R(+)-[2, 3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1, 4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (R(+)-WIN 55212-2), a synthetic cannabinoid agonist, decreased hippocampal neuronal loss after transient global cerebral ischemia and reduced infarct volume after permanent focal cerebral ischemia induced by middle cerebral artery occlusion in rats. The less active enantiomer S(-)-WIN 55212-3 was ineffective, and the protective effect of R(+)-WIN 55212-2 was blocked by the specific central cannabinoid (CB1) cannabinoid receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide-hydrochloride. R(+)-WIN 55212-2 also protected cultured cerebral cortical neurons from in vitro hypoxia and glucose deprivation, but in contrast to the receptor-mediated neuroprotection observed in vivo, this in vitro...
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abstractMarijuana and related drugs (cannabinoids) have been proposed as treatments for a widening spectrum of medical disorders. R(+)-[2, 3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1, 4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (R(+)-WIN 55212-2), a synthetic cannabinoid agonist, decreased hippocampal neuronal loss after transient global cerebral ischemia and reduced infarct volume after permanent focal cerebral ischemia induced by middle cerebral artery occlusion in rats. The less active enantiomer S(-)-WIN 55212-3 was ineffective, and the protective effect of R(+)-WIN 55212-2 was blocked by the specific central cannabinoid (CB1) cannabinoid receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide-hydrochloride. R(+)-WIN 55212-2 also protected cultured cerebral cortical neurons from in vitro hypoxia and glucose deprivation, but in contrast to the receptor-mediated neuroprotection observed in vivo, this in vitro...
pmid10191316
doi10.1523/JNEUROSCI.19-08-02987.1999
eissn15292401
date1999-04-15