schliessen

Filtern

 

Bibliotheken

Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein

The cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the influence of this cascade on neurogenesis in adult hippocampus was determined. Activation of the cAMP cascade by administration of rolipram,... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience 01 May 2002, Vol.22(9), pp.3673-82
Main Author: Nakagawa, Shin
Other Authors: Kim, Ji-Eun , Lee, Rena , Malberg, Jessica E , Chen, Jingshan , Steffen, Cathy , Zhang, Ya-Jun , Nestler, Eric J , Duman, Ronald S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1529-2401 ; PMID: 11978843 Version:1
Link: http://pubmed.gov/11978843
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline11978843
title: Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
format: Article
creator:
  • Nakagawa, Shin
  • Kim, Ji-Eun
  • Lee, Rena
  • Malberg, Jessica E
  • Chen, Jingshan
  • Steffen, Cathy
  • Zhang, Ya-Jun
  • Nestler, Eric J
  • Duman, Ronald S
subjects:
  • Cyclic Amp -- Metabolism
  • Cyclic Amp Response Element-Binding Protein -- Metabolism
  • Hippocampus -- Drug Effects
  • Neurons -- Drug Effects
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, 01 May 2002, Vol.22(9), pp.3673-82
description: The cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the influence of this cascade on neurogenesis in adult hippocampus was determined. Activation of the cAMP cascade by administration of rolipram, an inhibitor of cAMP breakdown, increased the proliferation of newborn cells in adult mouse hippocampus. In addition, rolipram induction of cell proliferation resulted in mature granule cells that express neuronal-specific markers. Increased cell proliferation is accompanied by activation of CREB phosphorylation in dentate gyrus granule cells, suggesting a role for this transcription factor. This possibility is supported by studies demonstrating that cell proliferation is decreased in conditional transgenic mice that express a dominant negative mutant of CREB in hippocampus. The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors...
language: eng
source:
identifier: E-ISSN: 1529-2401 ; PMID: 11978843 Version:1
fulltext: fulltext
issn:
  • 15292401
  • 1529-2401
url: Link


@attributes
ID46212054
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid11978843
sourceidmedline
recordidTN_medline11978843
sourceformatXML
sourcesystemPC
pqid71631277
display
typearticle
titleRegulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
creatorNakagawa, Shin ; Kim, Ji-Eun ; Lee, Rena ; Malberg, Jessica E ; Chen, Jingshan ; Steffen, Cathy ; Zhang, Ya-Jun ; Nestler, Eric J ; Duman, Ronald S
ispartofThe Journal of neuroscience : the official journal of the Society for Neuroscience, 01 May 2002, Vol.22(9), pp.3673-82
identifierE-ISSN: 1529-2401 ; PMID: 11978843 Version:1
subjectCyclic Amp -- Metabolism ; Cyclic Amp Response Element-Binding Protein -- Metabolism ; Hippocampus -- Drug Effects ; Neurons -- Drug Effects
descriptionThe cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the influence of this cascade on neurogenesis in adult hippocampus was determined. Activation of the cAMP cascade by administration of rolipram, an inhibitor of cAMP breakdown, increased the proliferation of newborn cells in adult mouse hippocampus. In addition, rolipram induction of cell proliferation resulted in mature granule cells that express neuronal-specific markers. Increased cell proliferation is accompanied by activation of CREB phosphorylation in dentate gyrus granule cells, suggesting a role for this transcription factor. This possibility is supported by studies demonstrating that cell proliferation is decreased in conditional transgenic mice that express a dominant negative mutant of CREB in hippocampus. The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors...
languageeng
source
version3
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/11978843$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Nakagawa, Shin
1Kim, Ji-Eun
2Lee, Rena
3Malberg, Jessica E
4Chen, Jingshan
5Steffen, Cathy
6Zhang, Ya-Jun
7Nestler, Eric J
8Duman, Ronald S
titleRegulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
descriptionThe cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the influence of this cascade on neurogenesis in adult hippocampus was determined. Activation of the cAMP cascade by administration of rolipram, an inhibitor of cAMP breakdown, increased the proliferation of newborn cells in adult mouse hippocampus. In addition, rolipram induction of cell proliferation resulted in mature granule cells that express neuronal-specific markers. Increased cell proliferation is accompanied by activation of CREB phosphorylation in dentate gyrus granule cells, suggesting a role for this transcription factor. This possibility is supported by studies demonstrating that cell proliferation is decreased in conditional transgenic mice that express a dominant negative mutant of CREB in hippocampus. The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors...
subject
0Cyclic Amp -- Metabolism
1Cyclic Amp Response Element-Binding Protein -- Metabolism
2Hippocampus -- Drug Effects
3Neurons -- Drug Effects
general
011978843
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
3MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline11978843
issn
015292401
11529-2401
rsrctypearticle
creationdate2002
addtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr4120020501
citationpf 3673 vol 22 issue 9
startdate20020501
enddate20020501
lsr30VSR-Enriched:[doi, pqid]
sort
titleRegulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
authorNakagawa, Shin ; Kim, Ji-Eun ; Lee, Rena ; Malberg, Jessica E ; Chen, Jingshan ; Steffen, Cathy ; Zhang, Ya-Jun ; Nestler, Eric J ; Duman, Ronald S
creationdate20020501
lso0120020501
facets
frbrgroupid8787398321956230234
frbrtype5
newrecords20190702
languageeng
creationdate2002
topic
0Cyclic Amp–Metabolism
1Cyclic Amp Response Element-Binding Protein–Metabolism
2Hippocampus–Drug Effects
3Neurons–Drug Effects
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Nakagawa, Shin
1Kim, Ji-Eun
2Lee, Rena
3Malberg, Jessica E
4Chen, Jingshan
5Steffen, Cathy
6Zhang, Ya-Jun
7Nestler, Eric J
8Duman, Ronald S
jtitleJournal Of Neuroscience : The Official Journal Of The Society For Neuroscience
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Nakagawa
1Kim
2Lee
3Malberg
4Chen
5Steffen
6Zhang
7Nestler
8Duman
aufirst
0Shin
1Ji-Eun
2Rena
3Jessica E
4Jingshan
5Cathy
6Ya-Jun
7Eric J
8Ronald S
au
0Nakagawa, Shin
1Kim, Ji-Eun
2Lee, Rena
3Malberg, Jessica E
4Chen, Jingshan
5Steffen, Cathy
6Zhang, Ya-Jun
7Nestler, Eric J
8Duman, Ronald S
atitleRegulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
jtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
risdate20020501
volume22
issue9
spage3673
pages3673-82
issn0270-6474
eissn1529-2401
formatjournal
genrearticle
ristypeJOUR
abstractThe cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the influence of this cascade on neurogenesis in adult hippocampus was determined. Activation of the cAMP cascade by administration of rolipram, an inhibitor of cAMP breakdown, increased the proliferation of newborn cells in adult mouse hippocampus. In addition, rolipram induction of cell proliferation resulted in mature granule cells that express neuronal-specific markers. Increased cell proliferation is accompanied by activation of CREB phosphorylation in dentate gyrus granule cells, suggesting a role for this transcription factor. This possibility is supported by studies demonstrating that cell proliferation is decreased in conditional transgenic mice that express a dominant negative mutant of CREB in hippocampus. The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors...
pmid11978843
doi10.1523/JNEUROSCI.22-09-03673.2002
date2002-05-01