schliessen

Filtern

 

Bibliotheken

Hippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats

The effects of kainic acid (KA) on neurogenesis in the developing rat hippocampus were investigated. Neonatal [postnatal day (P) 7] rats received a single bilateral intracerebroventricular infusion of KA (50 nmol in 1.0 microl) or vehicle. At P14, P25, P40, and P60, the spatial and temporal relation... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience 01 March 2003, Vol.23(5), pp.1742-9
Main Author: Dong, Hongxin
Other Authors: Csernansky, Cynthia A , Goico, Brian , Csernansky, John G
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1529-2401 ; PMID: 12629178 Version:1
Link: http://pubmed.gov/12629178
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline12629178
title: Hippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats
format: Article
creator:
  • Dong, Hongxin
  • Csernansky, Cynthia A
  • Goico, Brian
  • Csernansky, John G
subjects:
  • Apoptosis -- Physiology
  • Hippocampus -- Drug Effects
  • Kainic Acid -- Pharmacology
  • Neurons -- Drug Effects
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, 01 March 2003, Vol.23(5), pp.1742-9
description: The effects of kainic acid (KA) on neurogenesis in the developing rat hippocampus were investigated. Neonatal [postnatal day (P) 7] rats received a single bilateral intracerebroventricular infusion of KA (50 nmol in 1.0 microl) or vehicle. At P14, P25, P40, and P60, the spatial and temporal relationships between the neurodegeneration and neurogenesis induced by KA were explored using terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling (TUNEL) to detect the dying cells and 5-bromodeoxyuridine (BrdU) to label newly generated cells. There was progressive loss of neurons in the cornu ammonis (CA) 1 and CA3 subfields of the hippocampus at all time points in KA-treated rats. TUNEL staining identified dying cells at P14 through P60, mainly in the CA3 subfield. The number of TUNEL-positive cells decreased with age. Neurogenesis also was observed in the KA-treated hippocampus. The number of BrdU-positive cells in the dentate gyrus was significantly decreased at P14,...
language: eng
source:
identifier: E-ISSN: 1529-2401 ; PMID: 12629178 Version:1
fulltext: fulltext
issn:
  • 15292401
  • 1529-2401
url: Link


@attributes
ID195818263
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid12629178
sourceidmedline
recordidTN_medline12629178
sourceformatXML
sourcesystemPC
pqid73075986
display
typearticle
titleHippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats
creatorDong, Hongxin ; Csernansky, Cynthia A ; Goico, Brian ; Csernansky, John G
ispartofThe Journal of neuroscience : the official journal of the Society for Neuroscience, 01 March 2003, Vol.23(5), pp.1742-9
identifierE-ISSN: 1529-2401 ; PMID: 12629178 Version:1
subjectApoptosis -- Physiology ; Hippocampus -- Drug Effects ; Kainic Acid -- Pharmacology ; Neurons -- Drug Effects
descriptionThe effects of kainic acid (KA) on neurogenesis in the developing rat hippocampus were investigated. Neonatal [postnatal day (P) 7] rats received a single bilateral intracerebroventricular infusion of KA (50 nmol in 1.0 microl) or vehicle. At P14, P25, P40, and P60, the spatial and temporal relationships between the neurodegeneration and neurogenesis induced by KA were explored using terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling (TUNEL) to detect the dying cells and 5-bromodeoxyuridine (BrdU) to label newly generated cells. There was progressive loss of neurons in the cornu ammonis (CA) 1 and CA3 subfields of the hippocampus at all time points in KA-treated rats. TUNEL staining identified dying cells at P14 through P60, mainly in the CA3 subfield. The number of TUNEL-positive cells decreased with age. Neurogenesis also was observed in the KA-treated hippocampus. The number of BrdU-positive cells in the dentate gyrus was significantly decreased at P14,...
languageeng
source
version3
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/12629178$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Dong, Hongxin
1Csernansky, Cynthia A
2Goico, Brian
3Csernansky, John G
titleHippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats
descriptionThe effects of kainic acid (KA) on neurogenesis in the developing rat hippocampus were investigated. Neonatal [postnatal day (P) 7] rats received a single bilateral intracerebroventricular infusion of KA (50 nmol in 1.0 microl) or vehicle. At P14, P25, P40, and P60, the spatial and temporal relationships between the neurodegeneration and neurogenesis induced by KA were explored using terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling (TUNEL) to detect the dying cells and 5-bromodeoxyuridine (BrdU) to label newly generated cells. There was progressive loss of neurons in the cornu ammonis (CA) 1 and CA3 subfields of the hippocampus at all time points in KA-treated rats. TUNEL staining identified dying cells at P14 through P60, mainly in the CA3 subfield. The number of TUNEL-positive cells decreased with age. Neurogenesis also was observed in the KA-treated hippocampus. The number of BrdU-positive cells in the dentate gyrus was significantly decreased at P14,...
subject
0Apoptosis -- Physiology
1Hippocampus -- Drug Effects
2Kainic Acid -- Pharmacology
3Neurons -- Drug Effects
general
012629178
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
3MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline12629178
issn
015292401
11529-2401
rsrctypearticle
creationdate2003
addtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr4120030301
citationpf 1742 vol 23 issue 5
startdate20030301
enddate20030301
lsr30VSR-Enriched:[pqid, doi]
sort
titleHippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats
authorDong, Hongxin ; Csernansky, Cynthia A ; Goico, Brian ; Csernansky, John G
creationdate20030301
lso0120030301
facets
frbrgroupid8591907600331614968
frbrtype5
newrecords20190701
languageeng
creationdate2003
topic
0Apoptosis–Physiology
1Hippocampus–Drug Effects
2Kainic Acid–Pharmacology
3Neurons–Drug Effects
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Dong, Hongxin
1Csernansky, Cynthia A
2Goico, Brian
3Csernansky, John G
jtitleJournal Of Neuroscience : The Official Journal Of The Society For Neuroscience
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Dong
1Csernansky
2Goico
aufirst
0Hongxin
1Cynthia A
2Brian
3John G
au
0Dong, Hongxin
1Csernansky, Cynthia A
2Goico, Brian
3Csernansky, John G
atitleHippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats
jtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
risdate20030301
volume23
issue5
spage1742
pages1742-9
issn0270-6474
eissn1529-2401
formatjournal
genrearticle
ristypeJOUR
abstractThe effects of kainic acid (KA) on neurogenesis in the developing rat hippocampus were investigated. Neonatal [postnatal day (P) 7] rats received a single bilateral intracerebroventricular infusion of KA (50 nmol in 1.0 microl) or vehicle. At P14, P25, P40, and P60, the spatial and temporal relationships between the neurodegeneration and neurogenesis induced by KA were explored using terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling (TUNEL) to detect the dying cells and 5-bromodeoxyuridine (BrdU) to label newly generated cells. There was progressive loss of neurons in the cornu ammonis (CA) 1 and CA3 subfields of the hippocampus at all time points in KA-treated rats. TUNEL staining identified dying cells at P14 through P60, mainly in the CA3 subfield. The number of TUNEL-positive cells decreased with age. Neurogenesis also was observed in the KA-treated hippocampus. The number of BrdU-positive cells in the dentate gyrus was significantly decreased at P14,...
pmid12629178
doi10.1523/JNEUROSCI.23-05-01742.2003
date2003-03-01