schliessen

Filtern

 

Bibliotheken

Effects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery

This placebo-controlled, double-blind study was designed to assess the effects of magnesium sulphate and clonidine on peroperative haemodynamics, propofol consumption and postoperative recovery. Sixty ASA I-II patients undergoing spinal surgery were randomized into three groups. Group M received mag... Full description

Journal Title: British journal of anaesthesia April 2005, Vol.94(4), pp.438-41
Main Author: Altan, A
Other Authors: Turgut, N , Yildiz, F , Türkmen, A , Ustün, H
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0007-0912 ; PMID: 15653705 Version:1
Link: http://pubmed.gov/15653705
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline15653705
title: Effects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery
format: Article
creator:
  • Altan, A
  • Turgut, N
  • Yildiz, F
  • Türkmen, A
  • Ustün, H
subjects:
  • Adjuvants, Anesthesia -- Pharmacology
  • Anesthetics, Intravenous -- Administration & Dosage
  • Clonidine -- Pharmacology
  • Magnesium Sulfate -- Pharmacology
  • Propofol -- Administration & Dosage
ispartof: British journal of anaesthesia, April 2005, Vol.94(4), pp.438-41
description: This placebo-controlled, double-blind study was designed to assess the effects of magnesium sulphate and clonidine on peroperative haemodynamics, propofol consumption and postoperative recovery. Sixty ASA I-II patients undergoing spinal surgery were randomized into three groups. Group M received magnesium sulphate 30 mg kg(-1) as a bolus before induction and 10 mg kg(-1) h(-1) by infusion. Group CL received clonidine 3 microg kg(-1) as a bolus before induction and 2 microg kg(-1) h(-1) by infusion during the operation period. The same volume of isotonic solution was administered to the control group (group CT). Anaesthesia was induced with propofol and was maintained with propofol infusion [dose according to the bispectral index (BIS)], fentanyl and cisatracurium. Analysis of variance and the Bonferroni test were used for statistical analysis. Induction of anaesthesia with propofol was rapid in the presence of magnesium sulphate and clonidine. The time for BIS to reach 60 was significantly shorter in group M and group CL (P
language: eng
source:
identifier: ISSN: 0007-0912 ; PMID: 15653705 Version:1
fulltext: fulltext
issn:
  • 00070912
  • 0007-0912
url: Link


@attributes
ID93391590
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid15653705
sourceidmedline
recordidTN_medline15653705
sourceformatXML
sourcesystemOther
pqid67501423
display
typearticle
titleEffects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery
creatorAltan, A ; Turgut, N ; Yildiz, F ; Türkmen, A ; Ustün, H
ispartofBritish journal of anaesthesia, April 2005, Vol.94(4), pp.438-41
identifierISSN: 0007-0912 ; PMID: 15653705 Version:1
subjectAdjuvants, Anesthesia -- Pharmacology ; Anesthetics, Intravenous -- Administration & Dosage ; Clonidine -- Pharmacology ; Magnesium Sulfate -- Pharmacology ; Propofol -- Administration & Dosage
descriptionThis placebo-controlled, double-blind study was designed to assess the effects of magnesium sulphate and clonidine on peroperative haemodynamics, propofol consumption and postoperative recovery. Sixty ASA I-II patients undergoing spinal surgery were randomized into three groups. Group M received magnesium sulphate 30 mg kg(-1) as a bolus before induction and 10 mg kg(-1) h(-1) by infusion. Group CL received clonidine 3 microg kg(-1) as a bolus before induction and 2 microg kg(-1) h(-1) by infusion during the operation period. The same volume of isotonic solution was administered to the control group (group CT). Anaesthesia was induced with propofol and was maintained with propofol infusion [dose according to the bispectral index (BIS)], fentanyl and cisatracurium. Analysis of variance and the Bonferroni test were used for statistical analysis. Induction of anaesthesia with propofol was rapid in the presence of magnesium sulphate and clonidine. The time for BIS to reach 60 was significantly shorter in group M and group CL (P<0.0001) but postoperative recovery was slower with magnesium sulphate compared with the clonidine and control groups (P<0.0001). There was no statistical difference in heart rate and arterial blood pressure between the groups. Propofol requirements for induction and maintenance of anaesthesia were significantly lower with magnesium and clonidine (P<0.0001). Clonidine caused bradycardia and hypotension and magnesium sulphate caused delayed recovery, but can be used as adjuvant agents with careful management.
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/15653705$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Altan, A
1Turgut, N
2Yildiz, F
3Türkmen, A
4Ustün, H
titleEffects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery
description
0This placebo-controlled, double-blind study was designed to assess the effects of magnesium sulphate and clonidine on peroperative haemodynamics, propofol consumption and postoperative recovery.
1Sixty ASA I-II patients undergoing spinal surgery were randomized into three groups. Group M received magnesium sulphate 30 mg kg(-1) as a bolus before induction and 10 mg kg(-1) h(-1) by infusion. Group CL received clonidine 3 microg kg(-1) as a bolus before induction and 2 microg kg(-1) h(-1) by infusion during the operation period. The same volume of isotonic solution was administered to the control group (group CT). Anaesthesia was induced with propofol and was maintained with propofol infusion [dose according to the bispectral index (BIS)], fentanyl and cisatracurium. Analysis of variance and the Bonferroni test were used for statistical analysis.
2Induction of anaesthesia with propofol was rapid in the presence of magnesium sulphate and clonidine. The time for BIS to reach 60 was significantly shorter in group M and group CL (P<0.0001) but postoperative recovery was slower with magnesium sulphate compared with the clonidine and control groups (P<0.0001). There was no statistical difference in heart rate and arterial blood pressure between the groups. Propofol requirements for induction and maintenance of anaesthesia were significantly lower with magnesium and clonidine (P<0.0001).
3Clonidine caused bradycardia and hypotension and magnesium sulphate caused delayed recovery, but can be used as adjuvant agents with careful management.
subject
0Adjuvants, Anesthesia -- Pharmacology
1Anesthetics, Intravenous -- Administration & Dosage
2Clonidine -- Pharmacology
3Magnesium Sulfate -- Pharmacology
4Propofol -- Administration & Dosage
general
015653705
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
3MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline15653705
issn
000070912
10007-0912
rsrctypearticle
creationdate2005
addtitleBritish journal of anaesthesia
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41200504
citationpf 438 vol 94 issue 4
startdate20050401
enddate20050431
lsr30VSR-Enriched:[eissn, pqid, doi, pages]
sort
titleEffects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery
authorAltan, A ; Turgut, N ; Yildiz, F ; Türkmen, A ; Ustün, H
creationdate20050400
lso0120050400
facets
frbrgroupid8463923483399097249
frbrtype5
newrecords20190701
languageeng
creationdate2005
topic
0Adjuvants, Anesthesia–Pharmacology
1Anesthetics, Intravenous–Administration & Dosage
2Clonidine–Pharmacology
3Magnesium Sulfate–Pharmacology
4Propofol–Administration & Dosage
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Altan, A
1Turgut, N
2Yildiz, F
3Türkmen, A
4Ustün, H
jtitleBritish Journal Of Anaesthesia
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Altan
1Turgut
2Yildiz
3Türkmen
4Ustün
aufirst
0A
1N
2F
3H
au
0Altan, A
1Turgut, N
2Yildiz, F
3Türkmen, A
4Ustün, H
atitleEffects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery
jtitleBritish journal of anaesthesia
risdate200504
volume94
issue4
spage438
pages438-441
issn0007-0912
formatjournal
genrearticle
ristypeJOUR
abstractThis placebo-controlled, double-blind study was designed to assess the effects of magnesium sulphate and clonidine on peroperative haemodynamics, propofol consumption and postoperative recovery.
pmid15653705
doi10.1093/bja/aei070
eissn14716771
oafree_for_read
date2005-04