schliessen

Filtern

 

Bibliotheken

Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism

T cell immune responses play key roles in the pathogenesis of viral hepatitis, and innate immunity is known to be also activated during this process, however, the effects of innate immunity activation on T cell-mediated hepatitis remain obscure. Here we examined the effect of the activation of NK ce... Full description

Journal Title: Journal of hepatology March 2006, Vol.44(3), pp.446-54
Main Author: Wang, Jing
Other Authors: Sun, Rui , Wei, Haiming , Dong, Zhongjun , Gao, Bin , Tian, Zhigang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0168-8278 ; PMID: 16310275 Version:1
Link: http://pubmed.gov/16310275
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline16310275
title: Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism
format: Article
creator:
  • Wang, Jing
  • Sun, Rui
  • Wei, Haiming
  • Dong, Zhongjun
  • Gao, Bin
  • Tian, Zhigang
subjects:
  • Hepatitis -- Prevention & Control
  • Interferon Inducers -- Therapeutic Use
  • Killer Cells, Natural -- Immunology
  • Lymphocyte Activation -- Immunology
  • Poly I-C -- Therapeutic Use
  • T-Lymphocytes -- Immunology
ispartof: Journal of hepatology, March 2006, Vol.44(3), pp.446-54
description: T cell immune responses play key roles in the pathogenesis of viral hepatitis, and innate immunity is known to be also activated during this process, however, the effects of innate immunity activation on T cell-mediated hepatitis remain obscure. Here we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly I:C), on concanavalin A (Con A)-induced T cell-mediated liver injury. Mice received nontoxic intraperitoneal poly I:C injection before Con A intravenous administration. The liver injury was examined by measuring serum transaminase and pathology, and the function of hepatic lymphocytes was detected by FACS analysis. Poly I:C pretreatment protected against T cell-mediated hepatitis, as evidenced by decreased mortality, hepatic necrosis, serum transaminase levels and inflammatory cytokines (IL-4, IFN-gamma). The protective effect of poly I:C was diminished in NK-depleted mice, which could be partially restored by adoptive transfer of NK cells. Administration of poly I:C caused NKT and T cell apoptosis via enhancing expression of Fas protein on these cells and expression of Fas ligand on NK cells. These findings suggest that activation of NK cells by poly I:C prevents Con A-induced T cell-hepatitis via downregulation of T/NKT cells and subsequent reduction of inflammatory cytokines.
language: eng
source:
identifier: ISSN: 0168-8278 ; PMID: 16310275 Version:1
fulltext: fulltext
issn:
  • 01688278
  • 0168-8278
url: Link


@attributes
ID1122437606
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid16310275
sourceidmedline
recordidTN_medline16310275
sourceformatXML
sourcesystemPC
pqid67668015
galeid197819768
display
typearticle
titlePoly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism
creatorWang, Jing ; Sun, Rui ; Wei, Haiming ; Dong, Zhongjun ; Gao, Bin ; Tian, Zhigang
ispartofJournal of hepatology, March 2006, Vol.44(3), pp.446-54
identifierISSN: 0168-8278 ; PMID: 16310275 Version:1
subjectHepatitis -- Prevention & Control ; Interferon Inducers -- Therapeutic Use ; Killer Cells, Natural -- Immunology ; Lymphocyte Activation -- Immunology ; Poly I-C -- Therapeutic Use ; T-Lymphocytes -- Immunology
descriptionT cell immune responses play key roles in the pathogenesis of viral hepatitis, and innate immunity is known to be also activated during this process, however, the effects of innate immunity activation on T cell-mediated hepatitis remain obscure. Here we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly I:C), on concanavalin A (Con A)-induced T cell-mediated liver injury. Mice received nontoxic intraperitoneal poly I:C injection before Con A intravenous administration. The liver injury was examined by measuring serum transaminase and pathology, and the function of hepatic lymphocytes was detected by FACS analysis. Poly I:C pretreatment protected against T cell-mediated hepatitis, as evidenced by decreased mortality, hepatic necrosis, serum transaminase levels and inflammatory cytokines (IL-4, IFN-gamma). The protective effect of poly I:C was diminished in NK-depleted mice, which could be partially restored by adoptive transfer of NK cells. Administration of poly I:C caused NKT and T cell apoptosis via enhancing expression of Fas protein on these cells and expression of Fas ligand on NK cells. These findings suggest that activation of NK cells by poly I:C prevents Con A-induced T cell-hepatitis via downregulation of T/NKT cells and subsequent reduction of inflammatory cytokines.
languageeng
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/16310275$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Wang, Jing
1Sun, Rui
2Wei, Haiming
3Dong, Zhongjun
4Gao, Bin
5Tian, Zhigang
titlePoly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism
description
0T cell immune responses play key roles in the pathogenesis of viral hepatitis, and innate immunity is known to be also activated during this process, however, the effects of innate immunity activation on T cell-mediated hepatitis remain obscure. Here we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly I:C), on concanavalin A (Con A)-induced T cell-mediated liver injury.
1Mice received nontoxic intraperitoneal poly I:C injection before Con A intravenous administration. The liver injury was examined by measuring serum transaminase and pathology, and the function of hepatic lymphocytes was detected by FACS analysis.
2Poly I:C pretreatment protected against T cell-mediated hepatitis, as evidenced by decreased mortality, hepatic necrosis, serum transaminase levels and inflammatory cytokines (IL-4, IFN-gamma). The protective effect of poly I:C was diminished in NK-depleted mice, which could be partially restored by adoptive transfer of NK cells. Administration of poly I:C caused NKT and T cell apoptosis via enhancing expression of Fas protein on these cells and expression of Fas ligand on NK cells.
3These findings suggest that activation of NK cells by poly I:C prevents Con A-induced T cell-hepatitis via downregulation of T/NKT cells and subsequent reduction of inflammatory cytokines.
subject
0Hepatitis -- Prevention & Control
1Interferon Inducers -- Therapeutic Use
2Killer Cells, Natural -- Immunology
3Lymphocyte Activation -- Immunology
4Poly I-C -- Therapeutic Use
5T-Lymphocytes -- Immunology
general
016310275
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
3MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline16310275
issn
001688278
10168-8278
rsrctypearticle
creationdate2006
addtitleJournal of hepatology
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41200603
citationpf 446 vol 44 issue 3
startdate20060301
enddate20060331
lsr30VSR-Enriched:[galeid, pages, eissn, doi, pqid]
sort
titlePoly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism
authorWang, Jing ; Sun, Rui ; Wei, Haiming ; Dong, Zhongjun ; Gao, Bin ; Tian, Zhigang
creationdate20060300
lso0120060300
facets
frbrgroupid8491161711771634549
frbrtype5
newrecords20190701
languageeng
creationdate2006
topic
0Hepatitis–Prevention & Control
1Interferon Inducers–Therapeutic Use
2Killer Cells, Natural–Immunology
3Lymphocyte Activation–Immunology
4Poly I-C–Therapeutic Use
5T-Lymphocytes–Immunology
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Wang, Jing
1Sun, Rui
2Wei, Haiming
3Dong, Zhongjun
4Gao, Bin
5Tian, Zhigang
jtitleJournal Of Hepatology
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Wang
1Sun
2Wei
3Dong
4Gao
5Tian
aufirst
0Jing
1Rui
2Haiming
3Zhongjun
4Bin
5Zhigang
au
0Wang, Jing
1Sun, Rui
2Wei, Haiming
3Dong, Zhongjun
4Gao, Bin
5Tian, Zhigang
atitlePoly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism
jtitleJournal of hepatology
risdate200603
volume44
issue3
spage446
pages446-454
issn0168-8278
formatjournal
genrearticle
ristypeJOUR
abstractT cell immune responses play key roles in the pathogenesis of viral hepatitis, and innate immunity is known to be also activated during this process, however, the effects of innate immunity activation on T cell-mediated hepatitis remain obscure. Here we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly I:C), on concanavalin A (Con A)-induced T cell-mediated liver injury.
pmid16310275
doi10.1016/j.jhep.2005.08.015
eissn16000641
date2006-03